Patents Assigned to Adimab, Inc.
  • Method For Generating and Selecting Antibodies Against Target Protein
    Publication number: 20100227774
    Abstract: Compositions are provided that comprise antibody against membrane proteins such as chemokine receptors. In particular, monoclonal human antibodies against human CXCR4 are provided that are capable of inhibiting HIV infection and chemotaxis in human breast cancer cells. The antibodies can be used as prophylactics or therapeutics to prevent and treat HIV infection and cancer, for screening drugs, and for diagnosing diseases or conditions associated with interactions with chemokine receptors.
    Type: Application
    Filed: February 26, 2010
    Publication date: September 9, 2010
    Applicant: ADIMAB, INC.
    Inventors: SHAOBING HUA, LI ZHU
  • Method for generating and selecting antibodies against target protein
    Patent number: 7700302
    Abstract: Methods and compositions are provided for efficient, high throughput screening of antibody libraries against proteins targets, especially membrane proteins in yeast. In particular, methods are provided for screening a diverse antibody library for antibodies that bind to a membrane protein such as a chemokine receptor in yeast.
    Type: Grant
    Filed: November 6, 2006
    Date of Patent: April 20, 2010
    Assignee: Adimab, Inc.
    Inventors: Shaobing Hua, Li Zhu
  • Rationally Designed, Synthetic Antibody Libraries and Uses Therefor
    Publication number: 20100056386
    Abstract: The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity. The libraries are designed to reflect the preimmune repertoire naturally created by the human immune system, with or without DH segments derived from other species, and are based on rational design informed by examination of publicly available databases of antibody sequences.
    Type: Application
    Filed: March 13, 2009
    Publication date: March 4, 2010
    Applicant: Adimab, Inc.
    Inventors: Maximiliano Vasquez, Michael Feldhaus, Tillman U. Gerngross, K. D. Wittrup
  • Rationally Designed, Synthetic Antibody Libraries and Uses Therefor
    Publication number: 20090181855
    Abstract: The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity. The libraries are designed to reflect the preimmune repertoire naturally created by the human immune system and are based on rational design informed by examination of publicly available databases of human antibody sequences.
    Type: Application
    Filed: September 12, 2008
    Publication date: July 16, 2009
    Applicant: ADIMAB, INC.
    Inventors: Maximiliano Vasquez, Michael Feldhaus, Tillman U. Gerngross, K. Dane Wittrup