Patents Assigned to Adir et Compagnie
  • Arylalkyl(thio)carboxamides
    Patent number: 5721276
    Abstract: The invention relates to a compound selected from those of formula (I): ##STR1## in which A, B, X and R.sub.1 are as defined in the description, and medicinal product containing the same useful for treating a disorder of the melatoninergic system.
    Type: Grant
    Filed: May 30, 1996
    Date of Patent: February 24, 1998
    Assignee: Adir et Compagnie
    Inventors: Isabelle Lesieur, Patrick Depreux, Veronique Leclerc, Philippe Delagrange, Pierre Renard, Beatrice Guardiola Lemaitre
  • Pyridine compounds as melatonergic agents
    Patent number: 5714495
    Abstract: The invention relates to a compound selected from those of formula (I): ##STR1## in which: R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and X are as defined in the description and medicinal product containing the same useful for treating a disorder of the melatoninergic system.
    Type: Grant
    Filed: April 12, 1996
    Date of Patent: February 3, 1998
    Assignee: Adir et Compagnie
    Inventors: Marie-Claude Viaud, Gerald Guillaumet, Daniel Mazeas, Herve Vandepoel, Pierre Renard, Bruno Pfeiffer, Philippe Delagrange
  • Tricyclic amides
    Patent number: 5712312
    Abstract: The invention relates to a compound selected from these of formula (I): ##STR1## in which R.sub.7, R.sub.8, Y, n and A are as defined in the description, and medicinal product containing the same useful for treating a disorder of the melatoninergic system.
    Type: Grant
    Filed: April 12, 1996
    Date of Patent: January 27, 1998
    Assignee: Adir et Compagnie
    Inventors: Michel Langlois, Monique Mathe-Allainmat, Philippe Delagrange, Pierre Renard, Beatrice Guardiola
  • N-pyridyl carboxamides and derivatives
    Patent number: 5712294
    Abstract: A compound selected from those of formula (I): ##STR1## where m is equal to 0 or 1andHet, A, X, R, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and the ring ##STR2## are defined in the description, and a medicinal product comprising the same for treating an inflammatory disorder.
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: January 27, 1998
    Assignee: Adir Et Compagnie
    Inventors: Jean-Michel Robert, Odile Rideau, Sylvie Robert-Piessard, Jacqueline Courant, Guillaume Le Baut, Daniel-Henri Caignard, Pierre Renard, Gerard Adam
  • Arylalkyl(thio)amides
    Patent number: 5708020
    Abstract: A compound which is selected from those of formula (I) : ##STR1## in which A, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are as defined in the description,its optical isomers,and its addition salts thereof with a pharmaceutically-acceptable acid or base,and medicinal products containing the same which are useful for treating a disorder of the melatoninergic system.
    Type: Grant
    Filed: March 11, 1996
    Date of Patent: January 13, 1998
    Assignee: Adir Et Compagnie
    Inventors: Michel Langlois, Pierre Renard, Gerard Adam
  • Pseudopeptides derived from neurokinins
    Patent number: 5708016
    Abstract: A compound of formula (I): ##STR1## in which: R.sub.1 represents an indolyl, naphthyl, tetrahydronaphthyl, thienyl, phenyl, optionally substituted, or (C.sub.3 -C.sub.7)cycloalkyl group,n represents an integer such that 1.ltoreq.n.ltoreq.8,m represents an integer such that 1.ltoreq.m.ltoreq.4,R.sub.2 represents an unsubstituted or substituted benzyl group, an unsubstituted or substituted phenyl group or a linear or branched (C.sub.1 -C.sub.6)alkyl group, its enantiomers, diastereoisomers and epimers as well as its addition salts with a pharmaceutically acceptable acid or base, and medicinal products containing the same are useful as substance P antagonists.
    Type: Grant
    Filed: February 14, 1997
    Date of Patent: January 13, 1998
    Assignee: Adir et Compagnie
    Inventors: Jean-Luc Fauchere, Nathalie Kucharczyk-Gentric, Emmanuel Canet, Michel Lonchampt
  • Thiophene compounds
    Patent number: 5705525
    Abstract: The invention relates to thiophene compounds of formula: ##STR1## wherein: X.sub.1, X.sub.2, Y.sub.1 and Y.sub.2, which are identical or different, each represents hydrogen or halogen, (C.sub.1 -C.sub.5)-alkyl oralkoxy, or trifluoromethyl,R.sub.1 represents hydrogen or (C.sub.1 -C.sub.5)-alkyl,A represents a straight (C.sub.1 -C.sub.5)-hydrocarbon chain of which each carbon atom is optionally mono- or di-substituted by a (C.sub.1 -C.sub.5)-alkyl, andR.sub.2 represents hydrogen, (C.sub.1 -C.sub.6)-alkyl, cyclohexyl or benzyl;and their physiologically tolerable salts.The products of the invention may be used as anti-inflammatory agents.
    Type: Grant
    Filed: February 22, 1996
    Date of Patent: January 6, 1998
    Assignee: Adir et Compagnie
    Inventors: Michel Wierzbicki, Frederic Sauveur, Jacqueline Bonnet, Charles Tordjman
  • Indole, indazole and benzisoxazole compounds
    Patent number: 5703070
    Abstract: Compound of formula (I): ##STR1## in which: R.sub.1 represents hydrogen, halogen, alkyl, alkoxy, trihalomethyl or hydroxyl,R.sub.2 represents hydrogen, alkyl or phenyl which is optionally substituted, ##STR2## or alternatively ##STR3## represents --O--N.dbd., 1.ltoreq.n.ltoreq.6, ##STR4## represents any one of the groups defined in the description, its isomers and its addition salts with a pharmaceutically acceptable acid or base, a medicinal products containing the same are useful in the treatment of schizophrenia.
    Type: Grant
    Filed: June 6, 1996
    Date of Patent: December 30, 1997
    Assignee: Adir et Compagnie
    Inventors: Gilbert Lavielle, Olivier Muller, Mark Millan, Valerie Audinot
  • Thiophene compounds
    Patent number: 5703074
    Abstract: Thiophene compounds of formula: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are as defined in the description, and salts thereof with appropriate acids.Those compounds and their physiologically tolerable salts can be used as medicaments in the treatment of pathologies characterized by a loss of bone tissue.
    Type: Grant
    Filed: December 20, 1996
    Date of Patent: December 30, 1997
    Assignee: Adir Et Compagnie
    Inventors: Michel Wierzbicki, Frederic Sauveur, Marie-Francoise Boussard, Jacqueline Bonnet, Massimo Sabatini
  • Method of treating disorders of the melatoninergic system and a certain benzofuran containing compound
    Patent number: 5703121
    Abstract: The invention relates to a compound selected from those of formula (I): ##STR1## in which: R.sub.1, R.sub.2, R.sub.3 and A are as defined in the description,and Medicinal product containing the same useful for treating a disorder of the melatoninergic system.
    Type: Grant
    Filed: January 11, 1996
    Date of Patent: December 30, 1997
    Assignee: Adir Et Compagnie
    Inventors: Daniel Lesieur, Eric Fourmaintraux, Patrick Depreux, Philippe Delagrange, Pierre Renard, Beatrice Guardiola-Lemaitre
  • Use of benzopyran derivatives for the treatment of pathologies associated with the NA.sup.+ -independent CI-/HCO.sub.3 -exchanger
    Patent number: 5703118
    Abstract: A method of treating a mammal afflicted with a disorder associated with the Na.sup.+ -independent Cl.sup.- /HCO.sub.3 - exchanger comprising the step of administering a compound selected from those of formula (I): ##STR1## in which R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9, R.sub.10, R.sub.11 and n are as defined in the description, which is effective for alleviating the said disorder.
    Type: Grant
    Filed: May 3, 1996
    Date of Patent: December 30, 1997
    Assignee: Adir et Compagnie
    Inventors: Ludovic Durand, Jean-Paul Babingui, Claudie Moulin, Sylvie Robert-Piessard, Guillaume Le Baut, Elisabeth Scalbert, Daniel-Henri Caignard, Pierre Renard
  • Heterocyclic spiro compounds
    Patent number: 5698567
    Abstract: The invention provides new compounds pertaining to the class of:aryl methoxy phenyl alkyl heterocyclic spiro compounds, enantiomers, diastereoisomers and physiologically-tolerable salts thereof.For example:8-{2-?3-quinol-2-yl methoxy)phenyl!ethyl}-3,8-diaza-1-oxa-2-oxo spiro?4,5!decane is described.Medicinal products containing the same are useful in the treatment of any pathology involving modifications of leukotriene metabolism.
    Type: Grant
    Filed: May 16, 1996
    Date of Patent: December 16, 1997
    Assignee: Adir Et Compagnie
    Inventors: Claude Guillonneau, Yves Charton, Gilbert Regnier, Emmanuel Canet, Michel Lonchampt
  • Alkylated (hetero) cyclic compounds
    Patent number: 5693665
    Abstract: The invention relates to a compounds selected from these of formula (I): ##STR1## in which: R.sub.1, R.sub.2, R.sub.3 and A are as defined in the description, and a medicinal product containing the same useful for treating a melatoninergic disorder.
    Type: Grant
    Filed: January 10, 1996
    Date of Patent: December 2, 1997
    Assignee: Adir et Compagnie
    Inventors: Daniel Lesieur, Eric Fourmaintraux, Patrick Depreux, Philippe Delagrange, Pierre Renard, Beatrice Guardiola-Lemaitre
  • Benzopyran derivatives
    Patent number: 5691340
    Abstract: A compound selected from those of formula (I): ##STR1## where RA, RB, RC, RD, A, n, X, Y and Ar are defined in the description, and a medicinal product comprising the same for treating a mammal afflicted with a disease associated with sigma receptors.
    Type: Grant
    Filed: September 14, 1995
    Date of Patent: November 25, 1997
    Assignee: Adir et Compagnie
    Inventors: Genevieve Baziard-Mouysset, Sallouma Younes, Youssef Labssita, Marc Payard, Daniel-Henri Caignard, Pierre Renard, Marie-Claire Rettori
  • Aminoalkyl benzoxazolinones and benzothiazolinones
    Patent number: 5688811
    Abstract: The invention relates to a compound selected from those of formula (I): ##STR1## in which R.sub.1, R.sub.2, R.sub.3, X and n are as defined in the description, the optical isomers thereof, and the addition salts thereof with a pharmaceutically acceptable acid or baseand medicinal product containing the same, useful for treating a mammal afflicted with a pathology associated with the sigma receptors.
    Type: Grant
    Filed: December 8, 1995
    Date of Patent: November 18, 1997
    Assignee: Adir et Compagnie
    Inventors: Ange Mouithys-Mickalad, Patrick Depreux, Daniel Lesieur, Gerard Adam, Daniel-Henri Caignard, Pierre Renard, Marie-Claire Rettori
  • Aminoalkyl benzoxazolinones and benzothiazolinones
    Patent number: 5688820
    Abstract: The invention relates to a compound selected from those of formula (I): ##STR1## in which R.sub.1, R.sub.2, R.sub.3, X and n are as defined in the description, the optical isomers thereof, and the addition salts thereof with a pharmaceutically acceptable acid or base and medicinal product containing the same, useful for treating a mammal afflicted with a pathology associated with the sigma receptors.
    Type: Grant
    Filed: December 8, 1995
    Date of Patent: November 18, 1997
    Assignee: Adir et Compagnie
    Inventors: Ange Mouithys-Mickalad, Patrick Depreux, Daniel Lesieur, Gerard Adam, Daniel-Henri Caignard, Pierre Renard, Marie-Claire Rettori
  • 5-(arloxymethyl)oxazolines
    Patent number: 5686477
    Abstract: The invention relates to compounds of formula (I): ##STR1## wherein: R.sub.1 and R.sub.2 are selected, each independently of the other, from hydrogen and an alkyl radical,A is selected from the radicals: ##STR2## wherein: R.sub.3 represents a radical selected from halogen, alkyl, alkoxy, amino, 2-acetyl, alkylamino, dialkylamino, carboxy, alkoxycarbonyl, trifluoromethyl and cyano,R.sub.4, R.sub.5, R.sub.6, R.sub.7 and R.sub.8 are selected, each independently of the others, from hydrogen, a halogen, an alkyl, alkoxy, amino, alkylamino, dialkylamino, carboxy, alkoxycarbonyl, cyano and a trifluoromethyl radical,R.sub.
    Type: Grant
    Filed: November 2, 1995
    Date of Patent: November 11, 1997
    Assignee: Adir et Compagnie
    Inventors: Christian Jarry, Isabelle Forfar, Jean-Jacques Bosc, Pierre Renard, Elizabeth Scalbert, Beatrice Guardiola
  • Piperazine, piperidine and 1,2,5,6-tetrahydropyridine
    Patent number: 5684020
    Abstract: A compound selected from those of formula: ##STR1## wherein: A-B, n, D and E are as defined in the specification,their racemic mixtures, and their optical isomers,and also the physiologically tolerable salts thereof with appropriate acids.The products of the invention may be used therapeutically.
    Type: Grant
    Filed: January 30, 1997
    Date of Patent: November 4, 1997
    Assignee: Adir et Compagnie
    Inventors: Jean-Louis Peglion, Aimee Dessinges, Bertrand Goument, Mark Millan, Adrian Newman-Tancredi, Alain Gobert
  • 4-imidazolidinone compound
    Patent number: 5677325
    Abstract: Compound of formula (I): ##STR1## and its addition salts with a pharmaceutically acceptable acid or base, a medicinal products containing the same are useful as partial agonist of the glycine B site.
    Type: Grant
    Filed: December 20, 1996
    Date of Patent: October 14, 1997
    Assignee: Adir Et Compagnie
    Inventors: Alex Cordi, Jean-Michel Lacoste, Mark Millan, Valerie Audinot
  • Bioadhesive pharmaceutical composition for the controlled release of active principles
    Patent number: 5672356
    Abstract: Bioadhesive pharmaceutical composition for the controlled release of active principles locally across the buccal cavity or systemically across a mucous membrane, wherein it is composed of an active principle, a compound (A), a compound (B) and excipients as defined in the description.
    Type: Grant
    Filed: September 21, 1994
    Date of Patent: September 30, 1997
    Assignee: Adir et Compagnie
    Inventors: Isabelle Rault, Gerald Pichon, Alain Cuine