Abstract: The instant application provides methods and related compositions pertaining to novel HIV envelope proteins. In some embodiments, the invention relates to methods and compositions for the preparation, production, and administration of isolated novel HIV envelope nucleic acid and protein sequences suitable, for example, as vaccines against HIV.
Type:
Grant
Filed:
April 25, 2012
Date of Patent:
September 25, 2018
Assignees:
Advanced BioScience Laboratories, Inc., The United States of America as Represented by the Secretary of the Army, The Henry M. Jackson Foundation for the Advancement of Military Medicines, Inc.
Inventors:
Vaniambadi Kalyanaraman, Stephen Whitney, Thomas C. VanCott, Victoria Polonis, Carl Alving, Gary R. Matyas, Mangala Rao, Mary Marovich, Francine McCutchan, Sodsai Tovanabutra, Eric Sanders-Buell
Abstract: The instant application provides methods and related compositions pertaining to novel HIV envelope proteins. In some embodiments, the invention relates to methods and compositions for the preparation, production, and administration of isolated novel HIV envelope nucleic acid and protein sequences suitable, for example, as vaccines against HIV.
Type:
Application
Filed:
April 25, 2012
Publication date:
August 7, 2014
Applicants:
ADVANCED BIOSCIENCE LABORATORIES, INC., HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, THE GOVERNMENT OF THE USA, AS REPRESENTED BY THE SECRETARY
Inventors:
Vaniambadi Kalyanaraman, Stephen Whitney, Thomas C. Vancott, Victoria Polonis, Carl Alving, Gary R. Matyas, Mangala Rao, Mary Marovich, Francine McCutchan, Sodsai Tovanabutra, Eric Sanders-Buell
Abstract: Polyvalent, primary isolate nucleic acid compositions for inducing an immune response against HIV is disclosed. The compositions and methods described herein are for the use of a DNA composition that encodes one or more different HIV envelope glycoproteins. The DNA composition can encode an HIV Gag protein. The DNAs encoding one or more HIV proteins are a combination of different nucleic acids, such as DNA plasmids, generated from primary isolate DNA of different HIV major group genetic clades and/or different proteins. HIV protein compositions for inducing an immune response against HIV are disclosed. Methods for using the protein compositions as boosts following administration of the DNA compositions are provided.
Type:
Application
Filed:
February 3, 2011
Publication date:
July 14, 2011
Applicants:
UNIVERSITY OF MASSACHUSETTS, ADVANCED BIOSCIENCE LABORATORIES, INC.
Inventors:
Shan Lu, Shixia Wang, Ranajit Pal, Vaniambadi Kalyanaraman, Stephen Charles Whitney, Tim Keen, Balachandran Nair, Phillip Markham