Patents Assigned to Advanced Inhalation Research, Inc.
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Publication number: 20050191360Abstract: The invention generally relates to formulations having particles comprising phospholipids, bioactive agent and excipients and the pulmonary delivery thereof. Dry powder inhaled PTH formulations are disclosed. Improved formulations comprising DPPC, PTH and sodium citrate which are useful in the treatment of lowered PTH conditions are disclosed. Also, the invention relates to a method of for the pulmonary delivery of a bioactive agent comprising administering to the respiratory tract of a patient in need of treatment an effective amount of particles comprising a bioactive agent or any combination thereof in association, wherein release of the agent from the administered particles occurs in a rapid fashion. Kits containing receptacles of the formulations are also disclosed.Type: ApplicationFiled: February 4, 2005Publication date: September 1, 2005Applicant: Advanced Inhalation Research, Inc.Inventors: Richard Batycky, Michael Lipp
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Patent number: 6921528Abstract: A method for delivering a therapeutic dose of a bioactive agent to the pulmonary system, in a single, breath-activated step, comprises administering from a receptacle enclosing a mass of particles, to a subject's respiratory tract, particles which have a tap density of less than 0.4 g/cm3 and deliver at least about 50% of the mass of particles. Another method of delivering a therapeutic dose of a bioactive agent to the pulmonary system, in a single breath, includes administering from a receptacle enclosing a mass of particles, to a subject's respiratory tract, particles which have a tap density of at least 0.4 g/cm3 and deliver at least about 10 milligrams of the bioactive agent. The receptacle can have a volume of at least 0.37 cm3.Type: GrantFiled: October 8, 2003Date of Patent: July 26, 2005Assignee: Advanced Inhalation Research, Inc.Inventors: David A. Edwards, Richard P. Batvcky, Lloyd Johnston
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Patent number: 6858199Abstract: A method for delivering a therapeutic dose of a bioactive agent to the pulmonary system, in a single, breath-activated step, comprises administering from a receptacle enclosing a mass of particles, to a subject's respiratory tract, particles which have a tap density of less than 0.4 g/cm3 and deliver at least about 50% of the mass of particles. Another method of delivering a therapeutic dose of a bioactive agent to the pulmonary system, in a single breath, includes administering from a receptacle enclosing a mass of particles, to a subject's respiratory tract, particles which have a tap density of at least 0.4 g/cm3 and deliver at least about 10 milligrams of the bioactive agent. The receptacle can have a volume of at least 0.37 cm3.Type: GrantFiled: June 9, 2000Date of Patent: February 22, 2005Assignee: Advanced Inhalation Research, Inc.Inventors: David A. Edwards, Richard P. Batycky, Lloyd Johnston
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Publication number: 20050022812Abstract: The invention relates to a method of delivering an agent to the pulmonary system of a compromised patient, in a single breath-activated step, comprising administering a particle mass comprising an agent from an inhaler containing less than 5 milligrams of the mass, wherein at least about 50% of the mass in the receptacle is delivered to the pulmonary system of a patient. The invention also relates to receptacles containing the particle mass and the inhaler for use therein.Type: ApplicationFiled: June 14, 2004Publication date: February 3, 2005Applicant: Advanced Inhalation Research, Inc.Inventor: Jeffrey Hrkach
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Patent number: 6848197Abstract: Spray dried particles having specified aerodynamic characteristics are produced by atomizing a liquid feed and contacting the liquid feed with a drying gas, such as, for example, air or nitrogen. The humidity of the drying gas is controlled to a value, expressed, for instance, as dew point, which is known to produce particles having a specified tap density or aerodynamic diameter. Particles having a volume median geometric diameter greater than about 5 microns and a tap density less than about 0.4 g/cm3 are preferred.Type: GrantFiled: April 18, 2001Date of Patent: February 1, 2005Assignees: Advanced Inhalation Research, Inc., The Penn State Research Foundation, Inc.Inventors: Donghao Chen, Richard P. Batycky, Lloyd Johnston, Jeffrey Mintzes
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Publication number: 20050008633Abstract: The present invention is drawn to methods of enhancing bioavailability, pulmonary absorption and/or optimal dosing of a biologically active agent. The methods of the invention enhance the pulmonary absorption and bioavailability of a biologically active agent by administering to the pulmonary system of a subject, a biologically active agent and a macrophage inhibiting agent that is suitable for administration to a subject's pulmonary system.Type: ApplicationFiled: May 11, 2004Publication date: January 13, 2005Applicants: Advanced Inhalation Research Inc., Universite Catholique de LouvainInventors: Rita Vanbever, David Edwards
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Publication number: 20050003003Abstract: Particles which include a bioactive agent are prepared to have a desired matrix transition temperature. Delivery of the particles via the pulmonary system results in modulation of drug release from the particles. Sustained release and/or sustained pharmacologic action of the drug can be obtained by forming particles which include a combination of phospholipids that are miscible in one another and have a high matrix transition temperature.Type: ApplicationFiled: April 28, 2003Publication date: January 6, 2005Applicant: Advanced Inhalation Research, Inc.Inventors: Sujit Basu, Giovanni Caponetti, Daniel Deaver, Katharina Elbert, Jeffrey Hrkach, Michael Lipp
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Publication number: 20040216738Abstract: Inhalation device and associated method for facilitating inhalation by a patient of powder medicaments contained in a receptacle. The inhalation device has a chamber for receiving the receptacle. A ring is circumferentially coupled to an inner surface of the chamber to achieve a higher reproducible emitted dose of medicament from the receptacle. The inhalation device also includes an improved implement for puncturing the receptacle, requiring less force and experiencing fewer failures. The inhalation device also includes a means for indicating readiness.Type: ApplicationFiled: February 5, 2004Publication date: November 4, 2004Applicant: Advanced Inhalation Research, Inc.Inventors: David Edwards, Colleen Conlon, David L. Foshee, Jason R. Durkin, Tim Coker, Kevin Stapleton, Sarah Dreesen, Mark DeLong, Andrew Jones, Ryan McManus, Margaret Millar Saunders, Robert W. Spaller, Andrew Ziegler
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Publication number: 20040202721Abstract: Particles having a tap density less than about 0.4 g/cm3 are formed by spray drying from a colloidal solution including a carboxylic acid or salt thereof, a phospholipid, a divalent salt and a solvent such as an aqueous-organic solvent. The colloidal solution can also include a therapeutic, prophylactic or diagnostic agent. Preferred carboxylic acids include at least two carboxyl groups. Preferred phospholipids include phosphatidylcholines, phosphatidylethanolamines, phosphatidylglycerols, phophstidylserines, phosphatidylinositols and combinations thereof. The particles are suitable for pulmonary delivery.Type: ApplicationFiled: April 28, 2004Publication date: October 14, 2004Applicant: Advanced Inhalation Research, Inc.Inventors: Michael W. Lipp, Richard P. Batycky, Giovanni Caponetti
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Publication number: 20040168400Abstract: Method and apparatus for providing a precisely controlled amount of dry material to a container. In one embodiment, a system is provided for automated container filling. The system includes a container handling mechanism that includes a container block defining a container receptacle, and a cap carrier defining a cap receptacle. The system also includes a dosing portion having a dosing plate defining a dosing hole. The dosing plate is movable between two positions so that when the dosing plate is in the first position the dosing hole is positioned to receive a dose of powder. When the dosing plate is in the second position, the dosing hole is positioned to dispense the dose of powder into the container receptacle.Type: ApplicationFiled: February 23, 2004Publication date: September 2, 2004Applicant: Advanced Inhalation Research, Inc.Inventors: Lloyd P. Johnston, Kevin Stapleton, Ernest Penachio, Mark Wolff
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Publication number: 20040154618Abstract: Inhalation device and associated method for facilitating inhalation by a patient of powder medicaments contained in a receptacle. The inhalation device has a chamber for receiving the receptacle. A ring is circumferentially coupled to an inner surface of the chamber to achieve a higher reproducible emitted dose of medicament from the receptacle. The inhalation device also includes an improved implement for puncturing the receptacle, requiring less force and experiencing fewer failures.Type: ApplicationFiled: February 5, 2004Publication date: August 12, 2004Applicant: Advanced Inhalation Research, Inc.Inventors: David Edwards, Mark DeLong, Craig Dunbar, Ernest E. Penachio, Kevin Stapleton, Mark Wolff
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Publication number: 20040154619Abstract: Inhalation device and associated method for facilitating inhalation by a patient of powder medicaments contained in a receptacle. The inhalation device has a chamber for receiving the receptacle. A ring is circumferentially coupled to an inner surface of the chamber to achieve a higher reproducible emitted dose of medicament from the receptacle. The inhalation device also includes an improved implement for puncturing the receptacle, requiring less force and experiencing fewer failures. The inhalation device also includes a means for indicating readiness.Type: ApplicationFiled: February 5, 2004Publication date: August 12, 2004Applicant: Advanced Inhalation Research, Inc.Inventors: David Edwards, Colleen Conlon, David L. Foshee, Jason R. Durkin, Tim Coker, Kevin Stapleton, Sarah Dreesen, Mark DeLong, Andrew Jones, Ryan McManus, Margaret Millar Saunders, Robert W. Spaller, Andrew Ziegler
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Patent number: 6766799Abstract: Inhalation device and associated method for facilitating inhalation by a patient of powder medicaments contained in a receptacle. The inhalation device has a chamber for receiving the receptacle. A ring is circumferentially coupled to an inner surface of the chamber to achieve a higher reproducible emitted dose of medicament from the receptacle. The inhalation device also includes an improved implement for puncturing the receptacle, requiring less force and experiencing fewer failures.Type: GrantFiled: April 16, 2001Date of Patent: July 27, 2004Assignee: Advanced Inhalation Research, Inc.Inventors: David Edwards, Mark Delong, Craig Dunbar, Ernest E. Penachio, Kevin Stapleton, Mark Wolff
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Patent number: 6749835Abstract: Particles having a tap density less than about 0.4 g/cm3 are formed by spray drying from a colloidal solution including a carboxylic acid or salt thereof, a phospholipid, a divalent salt and a solvent such as an aqueous-organic solvent. The colloidal solution can also include a therapeutic, prophylactic or diagnostic agent. Preferred carboxylic acids include at least two carboxyl groups. Preferred phospholipids include phosphatidylcholines, phosphatidylethanolamines, phosphatidylglycerols, phophstidylserines, phosphatidylinositols and combinations thereof. The particles are suitable for pulmonary delivery.Type: GrantFiled: August 23, 2000Date of Patent: June 15, 2004Assignee: Advanced Inhalation Research, Inc.Inventors: Michael W. Lipp, Richard P. Batycky, Giovanni Caponetti
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Patent number: 6732732Abstract: Inhalation device and associated method for facilitating inhalation by a patient of powder medicaments contained in a receptacle. The inhalation device has a chamber for receiving the receptacle. A ring is circumferentially coupled to an inner surface of the chamber to achieve a higher reproducible emitted dose of medicament from the receptacle. The inhalation device also includes an improved implement for puncturing the receptacle, requiring less force and experiencing fewer failures. The inhalation device also includes a means for indicating readiness.Type: GrantFiled: October 10, 2002Date of Patent: May 11, 2004Assignee: Advanced Inhalation Research, Inc.Inventors: David Edwards, Colleen Conlon, Sarah Dreesen, Mark DeLong
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Publication number: 20040076589Abstract: A method for delivering a therapeutic dose of a bioactive agent to the pulmonary system, in a single, breath-activated step, comprises administering from a receptacle enclosing a mass of particles, to a subject's respiratory tract, particles which have a tap density of less than 0.4 g/cm3 and deliver at least about 50% of the mass of particles. Another method of delivering a therapeutic dose of a bioactive agent to the pulmonary system, in a single breath, includes administering from a receptacle enclosing a mass of particles, to a subject's respiratory tract, particles which have a tap density of at least 0.4 g/cm3 and deliver at least about 10 milligrams of the bioactive agent. The receptacle can have a volume of at least 0.37 cm3.Type: ApplicationFiled: October 8, 2003Publication date: April 22, 2004Applicant: Advanced Inhalation Research, Inc.Inventors: David A. Edwards, Richard P. Batvcky, Lloyd Johnston
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Patent number: 6715259Abstract: Method and apparatus for providing a precisely controlled amount of dry material to a container. In one embodiment, a system is provided for automated container filling. The system includes a container handling mechanism that includes a container block defining a container receptacle, and a cap carrier defining a cap receptacle. The system also includes a dosing portion having a dosing plate defining a dosing hole. The dosing plate is movable between two positions so that when the dosing plate is in the first position the dosing hole is positioned to receive a dose of powder. When the dosing plate is in the second position, the dosing hole is positioned to dispense the dose of powder into the container receptacle.Type: GrantFiled: January 23, 2002Date of Patent: April 6, 2004Assignee: Advanced Inhalation Research, Inc.Inventors: Lloyd P. Johnston, Kevin Stapleton, Ernest Penachio, Mark Wolff
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Publication number: 20040042970Abstract: The present invention is based, in part, on the unexpected discovery that particles for pulmonary delivery of a therapeutic, prophylactic or diagnostic agent that comprise a phospholipid and a sufficient amount of leucine can produce sustained effect of the agent. Specifically, particles for pulmonary delivery of a therapeutic, prophylactic or diagnostic agent that contain a phospholipid or combination of phospholipids, wherein the phospholipid or combination of phospholipids is present in the particles in an amount of about 1 to 46 weight percent; and leucine, wherein leucine is present in the particles in an amount of at least 46 weight percent, can contribute to sustained effect of the agent. Particles that comprise at least 46 weight percent leucine but that do not contain phospholipids do not exhibit these same sustained effect properties.Type: ApplicationFiled: March 19, 2003Publication date: March 4, 2004Applicant: Advanced Inhalation Research, Inc.Inventors: Sujit K. Basu, Giovanni Caponetti, Robert Clarke, Katharina J. Elbert
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Publication number: 20040018243Abstract: Particles which include a bioactive agent are prepared to have a desired matrix transition temperature. Delivery of the particles via the pulmonary system results in modulation of drug release from the particles. Sustained release of the drug can be obtained by forming particles which have a high matrix transition temperature, while fast release can be obtained by forming particles which have a low matrix transition temperature. Preferred particles include one or more phospholipids.Type: ApplicationFiled: April 28, 2003Publication date: January 29, 2004Applicant: Advanced Inhalation Research, Inc.Inventors: Sujit K. Basu, Jeffrey S. Hrkach, Giovanni Caponetti, Michael M. Lipp, Katharina Elbert, Wen-I Li
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Publication number: 20040018989Abstract: In one aspect, the invention is related to a method of treating a patient with Parkinson's disease, the method including administering to the respiratory tract of the patient particles that include more than about 90 weight percent (wt %) of levodopa. The particles are delivered to the patient's pulmonary system, preferably to the alveoli or the deep lung.Type: ApplicationFiled: March 19, 2003Publication date: January 29, 2004Applicant: Advanced Inhalation Research, Inc.Inventors: Blair Jackson, David J. Bennett, Raymond T. Bartus, Dwaine F. Emerich