Patents Assigned to Advanced Medicine, Inc.
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Patent number: 11292794Abstract: The present disclosure provides a compound that is useful for the treatment and prophylaxis of rabies. The present disclosure provides a compound represented by formula XXIF or formula XXIB: wherein R1, R2A, R2B, R3, and R4 are defined in the specification, a solvent, or a pharmaceutically acceptable salt thereof, use of such a compound, solvate, or pharmaceutically acceptable salt thereof for the treatment or prophylaxis of rabies and cancer, a pharmaceutical composition comprising such a compound, solvate, or pharmaceutically acceptable salt thereof, and a method for the treatment or prophylaxis of rabies and cancer using the same.Type: GrantFiled: February 14, 2020Date of Patent: April 5, 2022Assignee: Oita University Institute of Advanced Medicine, Inc.Inventors: Hiroyuki Kouji, Kentaro Yamada, Akira Katoh, Toshimasa Ishizaki, Shigeru Matsuoka, Akira Nishizono, Tadashi Mishina, Atsushi Yoshimori
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Publication number: 20030087307Abstract: Disclosed are multibinding compounds which are &bgr;2 adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, bronchitis. They are also useful in the treatment of nervous system injury and premature labor.Type: ApplicationFiled: March 28, 2002Publication date: May 8, 2003Applicant: Advanced Medicine, Inc.Inventors: Edmund J. Moran, Seok-Ki Choi
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Patent number: 6444786Abstract: Disclosed are derivatives of glycopeptide compounds having at least one substituent of the formula: —Ra—Y—Rb—(Z)x where Ra, Rb, Y, Z and x are as defined, and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.Type: GrantFiled: September 6, 2000Date of Patent: September 3, 2002Assignee: Advanced Medicine, Inc.Inventors: J. Kevin Judice, Paul Ross Fatheree, Bernice M. T. Lam, Michael R. Leadbetter, Martin S. Linsell, YongQi Mu, Sean Gary Trapp, Guang Yang, Yan Zhu
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Patent number: 6420354Abstract: The compounds of this invention comprise 2-10 ligands covalently connected, each of the ligands being capable of binding to a ligand binding site in a Na+ channel, thereby modulating the biological activities thereof.Type: GrantFiled: December 8, 1999Date of Patent: July 16, 2002Assignee: Advanced Medicine, Inc.Inventors: Daniel Marquess, Seok-Ki Choi, David T. Beattie, John H. Griffin, Scott Armstrong, Timothy J. Church, Thomas E. Jenkins
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Patent number: 6395724Abstract: Disclosed are multibinding compounds which inhibit cyclooxygenase-2 (COX-2), an enzyme which catalyzes the first committed step in the biosynthesis of prostaglandins. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is a moiety capable of binding to COX-2. The multibinding compounds of this invention are useful in the treatment inflammation, pain, fever and the like.Type: GrantFiled: June 7, 1999Date of Patent: May 28, 2002Assignee: Advanced Medicine, Inc.Inventors: J. Kevin Judice, Deborah L. Higgins, John H. Griffin
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Patent number: 6392012Abstract: Disclosed are derivatives of glycopeptide compounds having at least one substituent of the formula: —Ra—Y—Rb—(Z)x where Ra, Rb, Y, Z and x are as defined, and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.Type: GrantFiled: December 22, 1999Date of Patent: May 21, 2002Assignee: Advanced Medicine, Inc.Inventors: J. Kevin Judice, Paul Ross Fatheree, Bernice M. T. Lam, Michael R. Leadbetter, Martin S. Linsell, YongQi Mu, Sean Gary Trapp, Guang Yang, Yan Zhu
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Patent number: 6380356Abstract: Disclosed are multibinding compounds which are antibiotics effective against bacterial infections, in particular, Gram-negative bacterial infections. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is a polymyxin, circulin or octapeptin antibiotic or other suitable compound which binds to the LPS present in bacteria, in particular, Gram-negative bacteria. The multibinding compounds of this invention are useful for the prophylaxis and treatment of various bacterial infections caused by bacteria.Type: GrantFiled: December 7, 1999Date of Patent: April 30, 2002Assignee: Advanced Medicine, Inc.Inventors: John H. Griffin, J. Kevin Judice
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Patent number: 6362371Abstract: The present invention is directed to multibinding compounds which are &bgr;2 adrenergic receptor agonists and are therefore useful in the treatment and prevention of respiratory diseases such asthma, bronchitis, and the like. They are also useful in the treatment of nervous system injury and premature labor.Type: GrantFiled: June 2, 1999Date of Patent: March 26, 2002Assignee: Advanced Medicine, Inc.Inventors: Edmund J. Moran, John H. Griffin, Seok-Ki Choi
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Patent number: 6355810Abstract: Disclosed are multibinding compounds which inhibit 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-COA reductase), the rate limiting enzyme in cholesterol biosynthesis. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is a moiety capable of binding to HMG-CoA reductase and the distance between ligands is at least 10 Å. The multibinding compounds of this invention are useful in the treatment and prevention of hypercholesterolemia, hyperlipidemia, atherosclerosis and the like.Type: GrantFiled: June 4, 1999Date of Patent: March 12, 2002Assignee: Advanced Medicine, Inc.Inventors: John H. Griffin, Michael R. Leadbetter, Donald E. Schmidt, Jr.
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Patent number: 6355805Abstract: The present invention is directed to multibinding compounds which are &bgr;3 adrenergic receptor agonists and are therefore useful in the treatment and prevention of metabolic disorders such as obesity, diabetes, and the like.Type: GrantFiled: June 8, 1999Date of Patent: March 12, 2002Assignee: Advanced Medicine, Inc.Inventors: Seok-Ki Choi, Edmund J. Moran
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Patent number: 6355637Abstract: This invention provides novel quinazolinone compounds and pharmaceutically acceptable salts thereof, which are useful as local anesthetics. This invention also provides pharmaceutical compositions containing such compounds; methods for producing local anesthesia in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.Type: GrantFiled: September 28, 2000Date of Patent: March 12, 2002Assignee: Advanced Medicine, Inc.Inventors: Sabine M. Axt, Timothy J. Church, John R. Jacobsen, Thomas E. Jenkins, Yu-Hua Ji, Huiwei Wu
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Patent number: 6337423Abstract: Novel compounds, pharmaceutical compositions and methods are disclosed for producing local anesthesia of long-duration. The compounds of this invention are multibinding compounds that comprise from 2 to 10 ligands covalently attached to a linker or linkers, each ligand being capable of binding to a ligand binding site in a voltage-gated Na+ channel to modulate the biological processes/functions thereof.Type: GrantFiled: April 2, 1999Date of Patent: January 8, 2002Assignee: Advanced Medicine, Inc.Inventors: Sabine M. Axt, Timothy J. Church, Witold Hruzewicz, John R. Jacobsen, Thomas E. Jenkins, Yu-Hua Ji, J. Kevin Judice
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Patent number: 6288234Abstract: Disclosed are multibinding compounds which inhibit microsomal triglyceride transferase protein (MTP), a protein which mediates the transfer of lipids during the assembly of lipoproteins and related biomolecules. The multibinding compounds contain from 2 to 10 ligands covalently attached to one or more linkers. The multibinding compounds of this invention are useful for lowering serum lipid, cholesterol and/or triglyceride levels, and for preventing and treating disorders associated with hyperlipemia, hyperlipidemia, hyperlipoproteinemia, hypercholestrolemia, hypertriglyceridemia and the like, such atherosclerosis.Type: GrantFiled: June 4, 1999Date of Patent: September 11, 2001Assignee: Advanced Medicine, Inc.Inventor: John H. Griffin
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Patent number: 6288055Abstract: Novel multibinding compounds are disclosed. The compounds of the invention comprise from 2-10 ligands covalently connected, each of said ligands being capable of binding to an nAChR receptor, thereby modulating the biologcial processes/functions thereof.Type: GrantFiled: February 7, 2000Date of Patent: September 11, 2001Assignee: Advanced Medicine, Inc.Inventors: Maya Natarajan, Thomas E. Jenkins, John H. Griffin
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Patent number: 6274716Abstract: A combinatorial chemical library of compounds structurally related to the moenomycin class of antibiotics has the formula wherein D is a donor mono- or disaccharide, A is an acceptor monosaccharide, and P-R is a lipophosphoglycerate mimetic group. Members of the library have a glycosidic linkage between the anomeric carbon of D and the C2 carbon of A, and the D-A moiety is in turn covalently linked through the anomeric carbon of A to the P-R group. Members of the library exhibit their greatest structural diversity in terms of substitutions occurring at the C3 position of the A residue, substitutions at the C2 position of the D residue, and different P-R groups used in assembling the compounds. Members of the library are preferably synthesized by solid phase techniques involving stepwise coupling of the respective units to a support, functionalizing the A and/or D saccharides either before or after immobilizing them on the support, and cleaving the assembled compounds from the support.Type: GrantFiled: September 13, 1999Date of Patent: August 14, 2001Assignee: Advanced Medicine, Inc.Inventors: Nigel Mark Allanson, Tin Yau Chan, Nicole T. Hatzenbuhler, Rakesh K. Jain, Ramesh Kakarla, Rui Liang, Dashan Liu, Domingos J. Silva, Michael J. Sofia