Patents Assigned to ADVANCED MEDIX INC.
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Patent number: 9034051Abstract: A bone repair material being superior in apatite-forming ability and its stability in a storage and high in scratch resistance is disclosed. The material is produced by a method comprising the steps of: immersing a substrate made of titanium or a titanium alloy in a first aqueous solution that does not contain calcium ions but contains at least one cation selected from the group consisting of sodium ions and potassium ions and is alkaline; immersing the substrate in a second aqueous solution that does not contain phosphate ions but contains calcium ions; heating the substrate in a dry atmosphere; and treating the substrate with hot water of 60° C. or higher or with steam.Type: GrantFiled: May 23, 2013Date of Patent: May 19, 2015Assignee: ADVANCED MEDIX INC.Inventors: Tadashi Kokubo, Takashi Kizuki, Seiji Yamaguchi, Tomiharu Matsushita
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Publication number: 20130261765Abstract: A bone repair material being superior in apatite-forming ability and its stability in a storage and high in scratch resistance is disclosed. The material is produced by a method comprising the steps of: immersing a substrate made of titanium or a titanium alloy in a first aqueous solution that does not contain calcium ions but contains at least one cation selected from the group consisting of sodium ions and potassium ions and is alkaline; immersing the substrate in a second aqueous solution that does not contain phosphate ions but contains calcium ions; heating the substrate in a dry atmosphere; and treating the substrate with hot water of 60° C. or higher or with steam.Type: ApplicationFiled: May 23, 2013Publication date: October 3, 2013Applicant: ADVANCED MEDIX INC.Inventors: Tadashi Kokubo, Takashi Kizuki, Seiji Yamaguchi, Tomiharu Matsushita
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Patent number: 8470387Abstract: A bone repair material being superior in apatite-forming ability and its stability in a storage and high in scratch resistance is disclosed. The material is produced by a method comprising the steps of: immersing a substrate made of titanium or a titanium alloy in a first aqueous solution that does not contain calcium ions but contains at least one cation selected from the group consisting of sodium ions and potassium ions and is alkaline; immersing the substrate in a second aqueous solution that does not contain phosphate ions but contains calcium ions; heating the substrate in a dry atmosphere; and treating the substrate with hot water of 60° C. or higher or with steam.Type: GrantFiled: June 1, 2009Date of Patent: June 25, 2013Assignee: Advanced Medix Inc.Inventors: Tadashi Kokubo, Takashi Kizuki, Seiji Yamaguchi, Tomiharu Matsushita
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Publication number: 20110287070Abstract: Bone repair materials are disclosed, from which ions are hardly eluted in living body and which are superior in apatite-forming ability and resistance to apatite peeling and have a scratch resistance high enough for practical use. The material comprises a substrate made of titanium or titanium alloys, and a surface layer, made substantially of titanium oxide, along the surface of the substrate. The substrate has on the surface thereof irregularities of from 1 nm to 10 ?m in average in both width and depth. The layer has a zeta potential of +4.5 mV or more under an aqueous solution environment of pH 6 to 8, and a critical scratch resistance of 35 mN or more when vibration 100 ?m in amplitude is added to a stylus with a spring constant of 200 g/mm on the surface layer and the stylus is moved at a rate of 10 mm/sec under a load increasing at a rate of 100 mN/min.Type: ApplicationFiled: January 29, 2010Publication date: November 24, 2011Applicants: Chubu University Educational Foundation, Advanced Medix Inc., Sagawa Printing Co., Ltd.Inventors: Tadashi Kokubo, Tomiharu Matsushita, Deepak K. Pattanayak
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Publication number: 20090317278Abstract: An artificial bone which is easy to bond to a living bone and has a mechanical property approximate to that of a living bone is disclosed. The artificial bone comprises: a dense part made of titanium or a titanium alloy, in the shape of a frame that is approximate to a part of an outer face of a living bone, having a density of 95% or more; and a porous part made of sintered particles of titanium or a titanium alloy having the same or different composition as the titanium alloy for the dense part, in the shape approximate to the remaining part of the living bone, having a porosity of 40% or more, the dense part and the particles of the porous part being sintered to each other at an interface between the dense part and the porous part.Type: ApplicationFiled: August 28, 2007Publication date: December 24, 2009Applicants: JAPAN SCIENCE AND TECHNOLOGY AGENCY, CHUBU UNIVERSITY EDUCATIONAL FOUNDATION, ADVANCED MEDIX INC.Inventor: Tadashi Kokubo