Abstract: The present disclosure relates to a hemodialysis catheter that can monitor intravascular pressure using a MEMS sensor. The hemodialysis catheter comprises a venous lumen, an atrial lumen, and at least one MEMS system sensor. The hemodialysis catheter also comprises a data acquisition and processing system. The hemodialysis catheter can communicate with a monitor system to display pressure data.

Abstract: The present disclosure relates to a cap for protecting an imaging instrument from damage caused by impact or poor handling. Exemplary devices can include a rigid outer shell and soft inner lining surrounding a distal tip of the instrument, to be applied between instrument use, and during instrument transport, disinfection, sterilization, and storage.

Abstract: The present disclosure relates to a cap for protecting an imaging instrument from damage caused by impact or poor handling. Exemplary devices can include a rigid outer shell and soft inner lining surrounding a distal tip of the instrument, to be applied between instrument use, and during instrument transport, disinfection, sterilization, and storage.

Abstract: Effector-deficient anti-CD32a monoclonal antibodies are encompassed, as are method and uses for treating CD32a-mediated diseases and disorders, including, thrombocytopenia, allergy, hemostatic disorders, immune, inflammatory, and autoimmune disorders.

Abstract: The present disclosure relates to a cap for protecting an imaging instrument from damage caused by impact or poor handling. Exemplary devices can include a rigid outer shell and soft inner lining surrounding a distal tip of the instrument, to be applied between instrument use, and during instrument transport, disinfection, sterilization, and storage.

Abstract: Effector-deficient anti-CD32a monoclonal antibodies are encompassed, as are method and uses for treating CD32a-mediated diseases and disorders, including, thrombocytopenia, allergy, hemostatic disorders, immune, inflammatory, and autoimmune disorders.

Abstract: Effector-deficient anti-CD32a monoclonal antibodies are encompassed, as are method and uses for treating CD32a-mediated diseases and disorders, including, thrombocytopenia, allergy, hemostatic disorders, immune, inflammatory, and autoimmune disorders.

Abstract: The present disclosure provides a surgical planning and navigation system imports multiple medical imaging sources of the same body part for integrated display in the same coordinate. Images are converted into 3D volumes, spatially co-registering each image volume to a base anatomical image.

Abstract: A method for evaluating diastolic function of a heart includes measuring a volumetric flow of blood through the heart and determining volume change rates during a diastolic flow period. A diastolic index is formulated from a combination of volume change rates and features of the volumetric change and is weighted by the index for evaluating the weighted feature at a heightened sensitivity against a preselected value. The index weighting provides a measure of diastolic filling performance specific to the weighting parameter. As a result, guidance is provided in evaluating volume changes in heart failure patients, cardiac diastolic performance, medication/titration for diastolic performance, an athletic training program, and cardiac reserve. Guidance is also provided for improving exercise capacity in patients with diastolic dysfunction without requiring the patient to be evaluated during exertion.

Abstract: An anatomical training apparatus secures a body organ for demonstrating and training a surgical procedure on a body organ. Tubes extend from apertures in a base to orifices in the body organ to stabilize the body organ for surgical training. Training heart surgery is further improved by extending tubes to veins and arteries to not only stabilize the heart for demonstrating surgical techniques, but for forcing fluids to flow through the heart during the training.

Abstract: The present application discloses the effects of endothelial cell-dependent activation of the protein C anticoagulant pathway via detection of thrombin generation correlated with the activation of the protein C anticoagulant pathway in plasma in the presence of endothelial cells using a fluorogenic substrate-based thrombin generation assay.

Abstract: A method for measuring a generation of thrombin in a sample of whole blood as a function of time includes adding to a sample of whole blood a fluorogenic substrate and a thrombin activator to form an activated sample. A conversion product is permitted to form in the activated sample. Fluorescence is measured as a function of time from a fluorescent group that is released during the formation of the conversion product with the use of a fluorescence detector. The fluorescence detector operates in an extended range mode and has an increased sensitivity. Thrombin generation as a function of time can then be calculated from the measured fluorescence as a function of time.

Abstract: A method for measuring a generation of thrombin in a sample of whole blood as a function of time includes adding to a sample of whole blood a fluorogenic substrate and a thrombin activator to form an activated sample. A conversion product is permitted to form in the activated sample. Fluorescence is measured as a function of time from a fluorescent group that is released during the formation of the conversion product with the use of a fluorescence detector. The fluorescence detector operates in an extended range mode and has an increased sensitivity. Thrombin generation as a function of time can then be calculated from the measured fluorescence as a function of time.