Abstract: Systems for the generation of discovery ion currents. One of the systems includes a mass spectrometer providing ion current measurement. The system includes a controller coupled to the mass spectrometer. The system also includes a liquid handler coupled to the controller and the mass spectrometer. The controller is configured to identify a base average ion current of each mass to charge interval, the mass to charge interval comprising at least one mass to charge channel. The controller is configured to calculate a relative change between a current ion current measurement for a charge interval to the base average for the charge interval. The controller is configured to compare the relative change to a threshold. The controller is also configured to, in response to determining that the relative change exceeds the threshold, start fraction collection using the liquid handler.

Abstract: Surface extraction interface systems can include a seal assembly with a cavity assembly, an actuator, and a force gauge. Methods of preparing a sample for analysis can include: receiving data identifying characteristics of a surface supporting the sample; determining a pressure to be applied by a seal assembly against the surface; pressing a cavity assembly against the surface facing the open side of the cavity until the pressure is achieved; and extracting a sample from the surface by flowing a stream of extraction solvent through the sealed extraction cavity.

Abstract: Systems for the generation of discovery ion currents. One of the systems includes a mass spectrometer providing ion current measurement. The system includes a controller coupled to the mass spectrometer. The system also includes a liquid handler coupled to the controller and the mass spectrometer. The controller is configured to identify a base average ion current of each mass to charge interval, the mass to charge interval comprising at least one mass to charge channel. The controller is configured to calculate a relative change between a current ion current measurement for a charge interval to the base average for the charge interval. The controller is configured to compare the relative change to a threshold. The controller is also configured to, in response to determining that the relative change exceeds the threshold, start fraction collection using the liquid handler.

Abstract: Methods and systems for extraction of analytes from samples for analysis using mass spectrometers are described herein.

Abstract: Systems and methods for purification of radiotracers and non-radioactive materials produced by both microfluidic, conventional, semi-automated and manual synthesis systems are described herein.

Abstract: Methods and systems for mass spectrometry and more particularly to an interface providing charged particles to a mass spectrometer are described herein.

Abstract: A mechanical holder that provides for a confined sampling region for extraction and removal of chemical substances contained in a dried blood spot or other spot of sample is described herein.

Abstract: Methods and systems for mass spectrometry and more particularly to an interface providing charged particles to a mass spectrometer are described herein.

Abstract: Methods and systems for mass spectrometry and more particularly to an interface providing charged particles to a mass spectrometer are described herein.

Abstract: A mechanical holder that provides for a confined sampling region for extraction and removal of chemical substances contained in a dried blood spot or other spot of sample is described herein.