Patents Assigned to AEMase, Inc.
  • Engineered enzymes with methionine-gamma-lyase enzymes and pharmacological preparations thereof
    Patent number: 11584949
    Abstract: Methods and composition related to the engineering of a novel protein with methionine-?-lyase enzyme activity are described. For example, in certain aspects there may be disclosed a modified cystathionine-?-lyase (CGL) comprising one or more amino acid substitutions and capable of degrading methionine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with methionine depletion using the disclosed proteins or nucleic acids.
    Type: Grant
    Filed: November 21, 2019
    Date of Patent: February 21, 2023
    Assignee: AEMASE, INC.
    Inventors: George Georgiou, Everett Stone
  • Engineered enzymes with methionine-gamma-lyase enzymes and pharmacological preparations thereof
    Patent number: 10526638
    Abstract: Methods and composition related to the engineering of a novel protein with methionine-?-lyase enzyme activity are described. For example, in certain aspects there may be disclosed a modified cystathionine-?-lyase (CGL) comprising one or more amino acid substitutions and capable of degrading methionine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with methionine depletion using the disclosed proteins or nucleic acids.
    Type: Grant
    Filed: February 2, 2018
    Date of Patent: January 7, 2020
    Assignee: AEMase, Inc.
    Inventors: George Georgiou, Everett Stone
  • ENGINEERED ENZYMES WITH METHIONINE-GAMMA-LYASE ENZYMES AND PHARMACOLOGICAL PREPARATIONS THEREOF
    Publication number: 20180171380
    Abstract: Methods and composition related to the engineering of a novel protein with methionine-?-lyase enzyme activity are described. For example, in certain aspects there may be disclosed a modified cystathionine-?-lyase (CGL) comprising one or more amino acid substitutions and capable of degrading methionine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with methionine depletion using the disclosed proteins or nucleic acids.
    Type: Application
    Filed: February 2, 2018
    Publication date: June 21, 2018
    Applicant: AEMASE, INC.
    Inventors: George GEORGIOU, Everett STONE
  • Engineered enzymes with methionine-gamma-lyase enzymes and pharmacological preparations thereof
    Patent number: 9909163
    Abstract: Methods and composition related to the engineering of a novel protein with methionine-?-lyase enzyme activity are described. For example, in certain aspects there may be disclosed a modified cystathionine-?-lyase (CGL) comprising one or more amino acid substitutions and capable of degrading methionine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with methionine depletion using the disclosed proteins or nucleic acids.
    Type: Grant
    Filed: February 25, 2016
    Date of Patent: March 6, 2018
    Assignee: AEMase, Inc.
    Inventors: George Georgiou, Everett Stone
  • ENGINEERED ENZYMES WITH METHIONINE-GAMMA-LYASE ENZYMES AND PHARMACOLOGICAL PREPARATIONS THEREOF
    Publication number: 20160168620
    Abstract: Methods and composition related to the engineering of a novel protein with methionine-?-lyase enzyme activity are described. For example, in certain aspects there may be disclosed a modified cystathionine-?-lyase (CGL) comprising one or more amino acid substitutions and capable of degrading methionine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with methionine depletion using the disclosed proteins or nucleic acids.
    Type: Application
    Filed: February 25, 2016
    Publication date: June 16, 2016
    Applicant: AEMASE, INC.
    Inventors: George GEORGIOU, Everett STONE
  • Engineered enzymes with methionine-gamma-lyase enzymes and pharmacological preparations thereof
    Patent number: 9279119
    Abstract: Methods and composition related to the engineering of a novel protein with methionine-?-lyase enzyme activity are described. For example, in certain aspects there may be disclosed a modified cystathionine-?-lyase (CGL) comprising one or more amino acid substitutions and capable of degrading methionine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with methionine depletion using the disclosed proteins or nucleic acids.
    Type: Grant
    Filed: March 26, 2014
    Date of Patent: March 8, 2016
    Assignee: AEMase, Inc.
    Inventors: George Georgiou, Everett Stone
  • ENGINEERED ENZYMES WITH METHIONINE-GAMMA-LYASE ENZYMES AND PHARMACOLOGICAL PREPARATIONS THEREOF
    Publication number: 20140287484
    Abstract: Methods and composition related to the engineering of a novel protein with methionine-?-lyase enzyme activity are described. For example, in certain aspects there may be disclosed a modified cystathionine-?-lyase (CGL) comprising one or more amino acid substitutions and capable of degrading methionine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with methionine depletion using the disclosed proteins or nucleic acids.
    Type: Application
    Filed: March 26, 2014
    Publication date: September 25, 2014
    Applicant: AEMASE, INC.
    Inventors: George GEORGIOU, Everett STONE
  • Engineered enzymes with methionine-gamma-lyase enzymes and pharmacological preparations thereof
    Patent number: 8709407
    Abstract: Methods and composition related to the engineering of a novel protein with methionine-?-lyase enzyme activity are described. For example, in certain aspects there may be disclosed a modified cystathionine-?-lyase (CGL) comprising one or more amino acid substitutions and capable of degrading methionine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with methionine depletion using the disclosed proteins or nucleic acids.
    Type: Grant
    Filed: February 3, 2011
    Date of Patent: April 29, 2014
    Assignee: AEMase, Inc.
    Inventors: George Georgiou, Everett Stone