Patents Assigned to Aeris Therapeutics, Inc.
  • Patent number: 8361484
    Abstract: One aspect of the invention relates to a hydrogel comprising a polymer comprising a plurality of pendent hydroxyl groups, a crosslinker, and a sclerosing agent. Another aspect of the invention relates to a method for reducing lung volume in a patient comprising the steps of advancing into a region of a patient's lung via said patient's trachea a multi-lumen catheter lumen through a bronchoscope; and co-administering, through the multi-lumen catheter, a first mixture comprising a first amount of a polymer containing a plurality of pendent hydroxyl groups; a second mixture comprising a second amount of a crosslinker; and a third mixture comprising a third amount of a sclerosing agent; thereby forming a hydrogel in said region. In certain embodiments, the compositions and methods described herein are intended for use in the treatment of patients with emphysema of the lung.
    Type: Grant
    Filed: September 27, 2007
    Date of Patent: January 29, 2013
    Assignee: Aeris Therapeutics, Inc.
    Inventors: Edward P. Ingenito, Alexander Schwarz, Larry W. Tsai
  • Publication number: 20120245627
    Abstract: One aspect of the invention relates to a hydrogel comprising a non-natural polymer comprising a plurality of pendant nucleophilic groups and a crosslinker comprising at least two pendant electrophilic groups. Another aspect of the invention relates to a hydrogel comprising a non-natural polymer comprising a plurality of pendant electrophilic groups and a crosslinker comprising at least two pendant nucleophilic groups. Yet another aspect of the invention relates to a method for reducing lung volume in a patient comprising the step of administering a hydrogel composition as described herein. Further, hydrogels of the invention may be used to achieve pleurodesis, seal brochopleural fistulas, seal an air leak in a lung, achieve hemostasis, tissue sealing (e.g., blood vessels, internal organs), or any combination thereof. In certain embodiments, the compositions and methods described herein are intended for use in the treatment of patients with emphysema.
    Type: Application
    Filed: June 11, 2012
    Publication date: September 27, 2012
    Applicant: AERIS THERAPEUTICS, INC.
    Inventors: Edward P. Ingenito, James A. Krom, Alexander Schwarz, Larry W. Tsai
  • Patent number: 7861710
    Abstract: A hand-held apparatus that delivers pressurized breathing gas to the airway of a patient, thereby creating positive end expiratory pressure (PEEP) and reducing respiratory muscle fatigue. The apparatus includes a deformable reservoir, a breathing interface, and a pressure relief valve. The apparatus may include a means for creating fluid communication between the deformable reservoir and a source of pressurized breathing gas. The apparatus may also include an adjuster that allows a user to vary the pressure of the breathing gas contained in the deformable reservoir.
    Type: Grant
    Filed: July 2, 2007
    Date of Patent: January 4, 2011
    Assignee: Aeris Therapeutics, Inc.
    Inventor: Edward P. Ingenito
  • Patent number: 7819908
    Abstract: The invention includes a method for performing non-surgical lung volume reduction in a patient by applying an amount of energy with a catheter to a diseased alveolar region of the lung of a patient having emphysema, wherein the amount of energy is sufficient to damage the epithelial cells and the epithelial barrier within the diseased alveolar region of the lung and collapse at least a portion of said region thereby reducing the lung volume, and wherein the energy comprises thermal energy, electrical energy, and ultrasonic energy.
    Type: Grant
    Filed: December 17, 2004
    Date of Patent: October 26, 2010
    Assignee: Aeris Therapeutics, Inc.
    Inventor: Edward P. Ingenito
  • Patent number: 7654999
    Abstract: Devices, compositions, and methods for achieving non-surgical lung volume reduction (e.g., bronchoscopic lung volume reduction (BLVR)) are described. BLVR can be carried out by collapsing a region of the lung, adhering one portion of the collapsed region to another, and promoting fibrosis in or around the adherent tissue.
    Type: Grant
    Filed: August 26, 2003
    Date of Patent: February 2, 2010
    Assignee: Aeris Therapeutics, Inc.
    Inventor: Edward P. Ingenito
  • Patent number: 7654998
    Abstract: Devices, compositions, and methods for achieving non-surgical lung volume reduction (e.g., bronchoscopic lung volume reduction (BLVR)) are described. BLVR can be carried out by collapsing a region of the lung, adhering one portion of the collapsed region to another, and promoting fibrosis in or around the adherent tissue.
    Type: Grant
    Filed: August 23, 2000
    Date of Patent: February 2, 2010
    Assignee: Aeris Therapeutics, Inc.
    Inventor: Edward Ingenito
  • Publication number: 20080281352
    Abstract: One aspect of the invention relates to a hydrogel comprising a non-natural polymer comprising a plurality of pendant nucleophilic groups and a crosslinker comprising at least two pendant electrophilic groups. Another aspect of the invention relates to a hydrogel comprising a non-natural polymer comprising a plurality of pendant electrophilic groups and a crosslinker comprising at least two pendant nucleophilic groups. Yet another aspect of the invention relates to a method for reducing lung volume in a patient comprising the step of administering a hydrogel composition as described herein. Further, hydrogels of the invention may be used to achieve pleurodesis, seal brochopleural fistulas, seal an air leak in a lung, achieve hemostasis, tissue sealing (e.g., blood vessels, internal organs), or any combination thereof. In certain embodiments, the compositions and methods described herein are intended for use in the treatment of patients with emphysema.
    Type: Application
    Filed: May 8, 2008
    Publication date: November 13, 2008
    Applicant: AERIS THERAPEUTICS, INC.
    Inventors: Edward P. Ingenito, James A. Krom, Alexander Schwarz, Larry W. Tsai
  • Publication number: 20080261884
    Abstract: One aspect of the present invention relates to bronchoscopic lung volume reduction using solutions of biopolymers that can be polymerized in situ with a crosslinker and a polymeric additive which accelerates the cross-linking reaction. In certain embodiments, the biopolymer solutions can be in the form of a foam or gel. The biopolymer compositions disclosed herein may also be used for indications other than lung volume reduction, such as sealing fistulas or performing emergency tamponade of vessels.
    Type: Application
    Filed: April 3, 2008
    Publication date: October 23, 2008
    Applicant: AERIS THERAPEUTICS, INC.
    Inventors: Larry W. Tsai, Edward P. Ingenito
  • Patent number: 7300428
    Abstract: Devices, compositions, and methods for achieving non-surgical lung volume reduction (e.g., bronchoscopic lung volume reduction (BLVR)) are described. BLVR can be carried out by collapsing a region of the lung, adhering one portion of the collapsed region to another, and promoting fibrosis in or around the adherent tissue.
    Type: Grant
    Filed: December 11, 2004
    Date of Patent: November 27, 2007
    Assignee: Aeris Therapeutics, Inc.
    Inventor: Edward P. Ingenito
  • Publication number: 20070110813
    Abstract: One aspect of the present invention relates to compositions and methods comprising polyelectrolyte molecules for treating patients who have certain diseases. Aspects of the invention relate to using certain polyelectrolyte compositions in therapy. According to the invention polyelectrolyte compositions may be used, for example, to slow or stop cell growth, kill cells (e.g., via necrotic or apoptotic pathways), promote fibrosis, or a combination thereof. In one aspect of the invention, certain toxic (e.g., cytotoxic) properties of polyelectrolytes are exploited for therapeutic purposes. In certain embodiments, compositions and methods of the invention are used to target polyelectrolyte toxicity to predetermined regions within a subject, while minimizing undesirable toxicity at other regions with the subject. In certain embodiments, the present invention relates to lung-volume-reduction therapy using a polyelectrolyte composition.
    Type: Application
    Filed: October 31, 2006
    Publication date: May 17, 2007
    Applicant: AERIS THERAPEUTICS, INC.
    Inventors: Edward Ingenito, Alexander Schwarz, Larry Tsai