Abstract: Disclosed herein are compositions, methods, and systems for treating skin damage or signs of aging in a subject including obtaining whole blood from the subject, collecting platelet rich plasma (PRP) from the whole blood, forming a first topical formulation having the PRP, providing the first topical formulation to the subject for application to an area of skin damage on the subject, providing a second topical formulation to the subject having an activator such that when the second topical formulation is applied to the area of skin damage on top of the first formulation, the PRP is activated and growth factors are released into the area of skin damage. Systems and kits useful in performing the methods are also disclosed.

Abstract: A microneedling system may reciprocate a plurality of microneedles disposed on a handpiece into the skin of a patient. The microneedles and/or electrode plates may deliver RF energy to the patient for inducing collagen coagulation and regeneration. An interrogative modality such as ultrasound may combined into the microneedling handpiece or used as a separate instrument to interrogate the skin and identify or measure the thicknesses of constituent layers. The data obtained from the interrogative modality may be displayed and can be used to automatically adjust operating parameters of the microneedling device, including the penetration depth of the needles, the pulse duration, and/or the power level of the RF energy to optimize the treatment for the specific patient and/or condition being treated. The microneedling system may recall the skin measurements for distinct sectors of the skin which are expected to have different properties.

Abstract: Disclosed herein are compositions, methods, and systems for treating skin damage or signs of aging in a subject including obtaining whole blood from the subject, collecting platelet rich plasma (PRP) from the whole blood, forming a first topical formulation having the PRP, providing the first topical formulation to the subject for application to an area of skin damage on the subject, providing a second topical formulation to the subject having an activator such that when the second topical formulation is applied to the area of skin damage on top of the first formulation, the PRP is activated and growth factors are released into the area of skin damage. Systems and kits useful in performing the methods are also disclosed.

Abstract: Disclosed herein are compositions, methods, and systems for treating skin damage or signs of aging in a subject including obtaining whole blood from the subject, collecting platelet rich plasma (PRP) from the whole blood, forming a first topical formulation having the PRP, providing the first topical formulation to the subject for application to an area of skin damage on the subject, providing a second topical formulation to the subject having an activator such that when the second topical formulation is applied to the area of skin damage on top of the first formulation, the PRP is activated and growth factors are released into the area of skin damage. Systems and kits useful in performing the methods are also disclosed.

Abstract: Disclosed herein is a method of preparing a subject's cells for topical treatment of a subject in need. Also provided is a topical formulation and methods of treating a subject suffering a skin disorder and pain using the topical formulation. Also disclosed herein are devices and systems for micronizing an aspirate in preparation of such a topical formulation.

Abstract: A system and method for providing treatment feedback for a thermal treatment device (100) is provided. In certain embodiments, a thermal transmitter (120) is configured to apply an amount of thermal energy (104) to a target site (106), the thermal energy having a selected frequency and a selected power level for penetration to a depth beneath the surface of the skin. A thermal imager (140) is also provided, the thermal imager (140) being configured to capture thermal data and thermal images of the target site. The device may further provide a thermal display (160) configured to display the thermal images and thermal data, providing feedback to a user (201).