Abstract: An improved wound dressing is described. The wound dressing contains an allograft having at least one layer of human amnion and chorion tissues that has a size and shape appropriate for covering a wound, a base sheet for securing the allograft over the wound, and optionally a support layer to protect the allograft. Methods of preparing the wound dressing and using it in wound healing are also described. The products and methods improve the performance of the wound healing, e.g., by accelerating wound healing, reducing scar formation, inflammation and risk of infection.

Abstract: An applicator for use in a laparoscopic surgery is described. The applicator allows the effective delivery of a surgical dressing, such as an allograft having at least one layer of human amnion and chorion tissues, to the surgical site, to thereby improve the performance of the surgery, e.g., by reducing adhesions, scar formation while also reducing inflammation and risk of post-operative infection.

Abstract: A construct for use in an OB/GYN surgery is described. The construct contains an allograft having at least one layer of human amnion and chorion tissues, and has a size and shape appropriate for covering an incision or a surgical site resulting from the surgery. Methods of preparing the construct and using it in an OB/GYN surgery are also described. The products and methods improve the performance of the OB/GYN surgery, e.g., by reducing adhesions, scar formation while also reducing inflammation and risk of post-operative infection.

Abstract: A construct for use in an abdominal surgery is described. The construct contains an allograft having at least one layer of human amnion and chorion tissues, and has a size and shape appropriate for covering an incision or a surgical site resulting from the surgery. Methods of preparing the construct and using it in an abdominal surgery are also described. The products and methods improve the performance of the abdominal surgery, e.g., by reducing adhesions, scar formation while also reducing inflammation and risk of post-operative infection.

Abstract: Improved methods for heart valve repair surgery are described. The methods utilize an allograft comprising a layer of amnion to improve the performance and reduce complications of heart valve repair surgery and the allograft has a pre-made size and shape suitable for the application.

Abstract: Improved methods, compositions and kits for congenital heart disease surgeries are described. The methods utilize amniotic fluid and/or an allograft comprising a layer of amnion to improve the performance and reduce complications of the surgeries and the allograft has a pre-made size and shape suitable for the application.

Abstract: Improved methods for coronary artery bypass grafting surgeries are described. The methods utilize an allograft comprising a layer of amnion to improve the performance and reduce complications of the surgeries and the allograft has a pre-made size and shape suitable for the application.

Abstract: Improved methods for heart valve replacement surgery are described. The methods utilize an allograft comprising a layer of amnion to improve the performance and reduce complications of heart valve replacement surgery and the allograft has a pre-made size and shape suitable for the application.

Abstract: Improved methods for heart transplant are described. The methods utilize an allograft comprising a layer of amnion to improve the performance and reduce complications of the heart transplant surgery and the allograft has a pre-made size and shape suitable for the application.

Abstract: A construct for use in a minimally invasive surgery is described. The construct contains an allograft having at least one layer of human amnion and chorion tissues, and is adapted for insertion into a small incision or a cannula employed in the minimally invasive surgery for access to the surgical site. The allograft has a shape appropriate for covering the surgical site. Methods of preparing the construct and using it in a minimally invasive surgery are also described. The products and methods improve the performance of the minimally invasive surgery, e.g., by reducing adhesions, scar formation while also reducing inflammation and risk of post-operative infection.

Abstract: A construct for use in a surgical repair of a damaged or inflamed joint is described. The construct contains an allograft having at least one layer of human amnion and chorion tissues, and is adapted for enclosing a damaged or inflamed joint or for covering or replacing a damaged or inflamed joint sheath during the surgical repair. Methods of preparing the construct and using it in a surgical repair of a damaged or inflamed joint are also described. The products and methods improve the performance of the joint surgery, e.g., by reducing inflammation, inhibiting fibrosis, scarring, fibroblast proliferation and post-operative infection while also promoting more rapid healing of damaged or traumatized joints.

Abstract: Improved methods for the surgical repair of a damaged or severed nerve are described. The improvement includes covering the surgically repaired nerve or a damaged neurilemma with at least one of an amniotic fluid and a construct, or replacing the damaged neurilemma with the construct prior to wound closing during the surgery. The construct contains an allograft having at least one layer of amnion and chorion tissues, and a shape adapted for enclosing a damaged or severed nerve or for covering or replacing the damaged neurilemma during the surgical repair. The products and methods improve the performance of the nerve surgery, e.g., by reducing inflammation, inhibiting fibrosis, scarring, fibroblast proliferation, post-operative infection while also promoting more rapid healing of damaged or traumatized nerve structures.

Abstract: Improved methods for sport injury surgeries are described. The improvement includes covering a damaged site of fascia with at least one of an amniotic fluid and a construct for use in surgical repair of the sport injury prior to wound closing. The construct contains an allograft comprising at least one layer of human amnion and chorion tissues and the construct has a size and shape suitable for covering the damaged site of fascia. The method improves fascial membrane repair, reduces complications and recovery time of sport injury surgeries.

Abstract: Improved methods for a surgical repair of a muscle are described. The improvement includes covering a damaged site of muscle with at least one of an amniotic fluid and a replacement cover for muscle sheath prior to wound closing during the surgery. The replacement cover contains at least one layer of human amnion and chorion tissues and is adapted to a shape appropriate for enclosing the muscle. The methods reduce inflammation, inhibit fibrosis, scarring, fibroblast proliferation and post-operative infection, while also promote more rapid healing and smooth gliding of the affected muscle against adjacent structures. Related replacement covers, kits and methods of preparation are also described.

Abstract: It is described a construct for use in surgical repair of tendon. The construct contains at least one layer of human amnion and chorion tissues and is generally cylindrical with a C-shaped cross-section to allow for ease of implantation over the tendon. Methods for preparing the construct is described. In addition, an improved method for surgical repair of a damaged or diseased tendon using the construct is also described. The improved method reduces adhesions, scar formation, inflammation and risk of post-operative infection.