Patents Assigned to AFFICHEM
  • Dendrogenin A and antineoplastic agents for the treatment of chemosensitive or chemoresistant tumors
    Patent number: 10188666
    Abstract: Dendrogenin A and antineoplastic agents for the treatment of chemosensitive or chemoresistant tumors. The invention concerns a kit-of-parts comprising 5?-hydroxy-6?-[2-(1H-imidazol-4-yl)ethylamino]cholestan-3?-ol (Dendrogenin A) or a pharmaceutically acceptable salt thereof and an antineoplastic agent for use in the treatment of cancer. Furthermore, the invention concerns Dendrogenin A or a pharmaceutically acceptable salt thereof for use for treating a chemoresistant cancer.
    Type: Grant
    Filed: September 3, 2014
    Date of Patent: January 29, 2019
    Assignees: AFFICHEM, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), CENTRE HOSPITALIER UNIVERSITAIRE DE TOULOUSE
    Inventors: Philippe de Medina, Michael Paillasse, Christian Recher, Marc Poirot, Sandrine Silvente Poirot
  • Sterol derivatives for treating neurosensory hearing loss, and corresponding composition
    Patent number: 10092577
    Abstract: The invention relates to a composition for preventing bearing loss in subject or for at least partially restoring bearing in a subject having a reduced auditory function. The composition comprises at least one sterol compound inducing neuron differentiation. Said composition is placed in contact with at least part of the cochlea.
    Type: Grant
    Filed: July 28, 2015
    Date of Patent: October 9, 2018
    Assignee: Affichem
    Inventors: Philippe De Medina, Michaël Paillasse, Mats Ulfendahl
  • METHODS OF DIAGNOSING CANCER AND OF PREDICTING RESPONSE OF CANCER TO DENDROGENIN A TREATMENT
    Publication number: 20170321283
    Abstract: The present invention relates to methods for the diagnosis and the treatment of cancer, in particular breast cancer. In particular, the present invention relates to a method of diagnosing cancer in a subject comprising the steps of i) determining the expression level of hGSTA1 in a tumor sample obtained from the subject, ii) comparing the expression level determined at step i) with its predetermined reference value and ii) concluding that the subject suffers from a cancer when the expression level of hGSTA1 is lower than its predetermined reference value.
    Type: Application
    Filed: November 16, 2015
    Publication date: November 9, 2017
    Applicants: INSERM (Institut National De La Sante Et De La Recherche Medicale), Universite Paul Sabtier Toulouse III, Affichem
    Inventors: Marc POIROT, Sandrine SILVENTE-POIROT, Emmanuel NOGUER
  • COSMETIC AND/OR DERMATOLOGICAL COMPOSITION FOR COLOURING THE SKIN
    Publication number: 20170216179
    Abstract: The invention relates to a composition which contains an aqueous solution of certain elements of a family of sterol derivatives, which enable improved tanning of the skin due to considerable penetration of the molecules thereof. Preferably, the composition also contains an ionic solution of cationic association complexes constituting an acid amphiphilic carrier.
    Type: Application
    Filed: March 24, 2015
    Publication date: August 3, 2017
    Applicants: AFFICHEM, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ PAUL SABATIER - TOULOUSE III (UPS)
    Inventors: Cécile BIZE, Michaël PAILLASSE, Philippe DE MEDINA, Sandrine SILVENTE-POIROT, Marc POIROT, Muriel BLANZAT, Isabelle RICO-LATTES, Emile PEREZ
  • STEROL DERIVATIVES FOR TREATING NEUROSENSORY HEARING LOSS, AND CORRESPONDING COMPOSITION
    Publication number: 20170209465
    Abstract: The invention relates to a composition for preventing bearing loss in subject or for at least partially restoring bearing in a subject having a reduced auditory function. The composition comprises at least one sterol compound inducing neuron differentiation. Said composition is placed in contact with at least part of the cochlea.
    Type: Application
    Filed: July 28, 2015
    Publication date: July 27, 2017
    Applicant: AFFICHEM
    Inventors: Philippe DE MEDINA, Michaël PAILLASSE, Mats ULFENDAHL
  • ACID ADDITION SALTS OF 5ALPHA-HYDROXY-6BETA-[2-(1H-IMIDAZOL-4-YL)ETHYLAMINO]CHOLESTAN-3BETA-OL
    Publication number: 20140274984
    Abstract: The present invention relates to acid addition salts of 5?-hydroxy-6?-[2-(1H-imidazol-4-yl)ethylamino]cholestan-3?-ol, to their preparation and to applications thereof.
    Type: Application
    Filed: October 17, 2012
    Publication date: September 18, 2014
    Applicants: AFFICHEM, INSERM (Institute National de la Sante et de la Recherche Medicale
    Inventors: Marc Poirot, Sandrine Poirot, Philippe de Medina, Michael Paillasse
  • Methods for Determining the Oncogenic Condition of Cell, Uses Thereof, and Methods for Treating Cancer
    Publication number: 20140221353
    Abstract: The invention relates to methods for detecting the oncogenic condition of cells, including step where the amount of the OCDO compound in said cells is measured, and to the uses thereof. The invention further relates to OCDO inhibitors for use in methods for treating cancer.
    Type: Application
    Filed: December 5, 2013
    Publication date: August 7, 2014
    Applicants: Affichem, INSERM (Institut National de la Sante et de la Recherche Medicale)
    Inventors: Philippe De Medina, Michael Paillasse, Marc Poirot, Sandrine Silvente-Poirot
  • METHODS FOR DETERMINING THE ONCOGENIC CONDITION OF CELL, USES THEREOF, AND METHODS FOR TREATING CANCER
    Publication number: 20120100124
    Abstract: The invention relates to methods for detecting the oncogenic condition of cells, including step where the amount of the OCDO compound in said cells is measured, and to the uses thereof. The invention further relates to OCDO inhibitors for use in methods for treating cancer.
    Type: Application
    Filed: June 25, 2010
    Publication date: April 26, 2012
    Applicants: INSERM (Institut National de la Sante et de la Recherche Medicale), AFFICHEM
    Inventors: Philippe De Medina, Michaél Paillasse, Marc Poirot, Sandrine Silvente-Poirot