Patents Assigned to Aileron Therapeutics, Inc.
  • PEPTIDOMIMETIC MACROCYCLES WITH IMPROVED PROPERTIES
    Publication number: 20100298201
    Abstract: The present invention provides biologically active peptidomimetic macrocycles with improved properties relative to their corresponding polypeptides. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applications.
    Type: Application
    Filed: November 24, 2009
    Publication date: November 25, 2010
    Applicant: AILERON Therapeutics, Inc.
    Inventors: Huw M. Nash, David Allen Annis, Rosana Kapeller-Libermann, Tomi K. Sawyer, Noriyuki Kawahata
  • PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20100216688
    Abstract: The present invention provides biologically active crosslinked polypeptides with improved properties relative to their corresponding precursor polypeptides, having good cell penetration properties and reduced binding to human proteins. The invention additionally provides methods of identifying and making such improved polypeptides.
    Type: Application
    Filed: September 22, 2009
    Publication date: August 26, 2010
    Applicant: AILERON Therapeutics, Inc.
    Inventors: Huw M. Nash, David Allen Annis, Rosana Kapeller-Llbermann, Tomi K. Sawyer
  • METHODS FOR PREPARING PURIFIED POLYPEPTIDE COMPOSITIONS
    Publication number: 20100210515
    Abstract: The present invention relates to purified peptidomimetic macrocycles. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applications.
    Type: Application
    Filed: September 22, 2009
    Publication date: August 19, 2010
    Applicant: AILERON Therapeutics, Inc.
    Inventors: Huw M. Nash, Matthew Iadanza, Christopher Leitheiser, Noriyuki Kawahata
  • BIS-SULFHYDRYL MACROCYCLIZATION SYSTEMS
    Publication number: 20100184628
    Abstract: The present invention provides novel peptidomimetic macrocycles and methods for their preparation and use, as well as amino acid analogs and macrocycle-forming linkers, and kits useful in their production.
    Type: Application
    Filed: January 19, 2010
    Publication date: July 22, 2010
    Applicant: AILERON Therapeutics, Inc., a Delaware Corporation
    Inventor: Huw M. Nash
  • BIOLOGICALLY ACTIVE PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20090326192
    Abstract: The present invention provides biologically active peptidomimetic macrocycles with improved properties relative to their corresponding polypeptides. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applications.
    Type: Application
    Filed: April 8, 2009
    Publication date: December 31, 2009
    Applicant: AILERON THERAPEUTICS, INC.
    Inventors: Huw M. Nash, Rosana Kapeller-Libermann, Tomi K. Sawyer, Noriyuki Kawahata, Vincent Guerlavais, Matthew Iadanza
  • Therapeutic peptidomimetic macrocycles
    Publication number: 20090275519
    Abstract: The present invention provides biologically active peptidomimetic macrocycles for the treatment of cell proliferative disorders such as cancer and immunoproliferative disease.
    Type: Application
    Filed: February 9, 2009
    Publication date: November 5, 2009
    Applicant: AILERON Therapeutics, Inc.
    Inventors: Huw M. Nash, David Allen Annis, Rosana Kapeller-Libermann, Tomi K. Sawyer, Noriyuki Kawahata, Jiawen Han
  • Bis-Sulfhydryl Macrocyclization Systems
    Publication number: 20090088553
    Abstract: The present invention provides novel peptidomimetic macrocycles and methods for their preparation and use, as well as amino acid analogs and macrocycle-forming linkers, and kits useful in their production.
    Type: Application
    Filed: June 16, 2008
    Publication date: April 2, 2009
    Applicant: AILERON Therapeutics, Inc., a Delaware Corporation
    Inventor: Huw M. Nash
  • BIS-SULFHYDRYL MACROCYCLIZATION SYSTEMS
    Publication number: 20090047711
    Abstract: The present invention provides novel peptidomimetic macrocycles and methods for their preparation and use, as well as amino acid analogs and macrocycle-forming linkers, and kits useful in their production.
    Type: Application
    Filed: December 14, 2007
    Publication date: February 19, 2009
    Applicant: AILERON THERAPEUTICS, INC.
    Inventor: Huw M. NASH
  • Triazole Macrocycle Systems
    Publication number: 20080262200
    Abstract: The present invention provides novel peptidomimetic macrocycles and methods for their preparation and use, as well as amino acid analogs and macrocycle-forming linkers, and kits useful in their production.
    Type: Application
    Filed: February 25, 2008
    Publication date: October 23, 2008
    Applicant: Aileron Therapeutics, Inc., A Delaware Corporation
    Inventor: Huw M. Nash