Abstract: Rear wheel hub of a two-wheel vehicle, secured to a tooth transmission gear and a brake disc, is noteworthy in that it is arranged so as to have in each of its two possible positions of mounting 180° apart, a toothed gear (7; 14, 15) on the side where the chain is located and the brake disc (6, 14b, 15b) on the side where the disc brake is located; such a hub comprises three interconnected parts, namely a central core (3) symmetrical relative to a transverse medial plane (P), comprising on each of its two front surfaces (3a, 3b), a same number of interfitting connecting elements (11), male or female, distributed about the axis (x, y) of the hub, and flanges (4, 5) connected respectively to the two front surfaces (3a, 3b) of the hub, one carrying the disc brake (6) and the other the toothed transmission gear (7), each of these flanges (4, 5) comprising, on its surface (4b, 5b) turned toward the associated surface (3a, 3b) of the hub (3), complementary male or female elements (12) coacting with the elements