Abstract: The present invention provides a method of detecting and diagnosing myocardial infarction which detects myocardial infarction by immunoassay using a monoclonal antibody having specific reactivity for human hepatocyte growth factor (HGF) as obtained by using human HGF as immunogen as well as a disganostic agent for myocardial infarction which comprises, as essential component thereof, the monoclonal antibody mentioned above. The method of the present invention makes it possible to detect and diagnose patients with myocardial infarction.

Abstract: The present invention discloses a method of inhibiting secretion of inflammatory cytokines in a host which includes administering one or more digitalis compounds in an amount effective for inhibiting secretion of an inflammatory cytokine to the host in need of inhibition of secretion of the inflammatory cytokine. The invention also discloses a method of treating diseases caused by abnormal formation or abnormal secretion of inflammatory cytokines. The invention is useful in the treatment of various diseases ascribed to abnormal secretion/formation of IL=6, IL-8, MCAF, G-CSF and/or GM-CSF.

Abstract: This invention provides a method of inhibiting graft rejection comprising administering a carbostyril derivative and/or its salt to a subject in need of such treatment. The method of this invention enhances the graft survival rate and can be advantageously used in the transplantation of various organs and tissues. This invention also relates to a method for inhibiting IL-1 production comprising administering a carbostyril derivative and/or its salt to a subject in need of such treatment. This method is effective in the prevention and treatment of diseases arising from excess IL-1 production, such as inflammatory diseases, osteoporosis, myelocytic leukemia, etc.