Abstract: A container system for reagents and other substances used in a medical diagnostic apparatus. The container system includes a vial made of blow-molded plastic, which can withstand lyophilization. The bottom portion of the vial has an annular groove and is shaped as a truncated cone below the annular groove. An auxiliary member can be snap-connected to the vial at the annular groove so that the vial will stand upright on a flat surface and contains a central aperture through which the vial remains in contact with the flat surface. The container system also includes a stopper at the mouth of the vial and a snap-on plastic cover to secure the stopper. The cover has a tab which is kept at a raised position by a lifter protrusion which bears against the stopper. The cover has tearslots which are ripped when the tab is pulled. One of the tearslots is shorter than the other and keeps the tab from being entirely detached from the remainder of the cover when the tab is pulled.

Abstract: The present invention comprises the epitope recognized by the human monoclonal antibody 16-18, the human tumor antigen containing this epitope, which we have identified, isolated and characterized, and anti-idiotypic antibodies to human MCA 16-88, which comprise the same epitope. The invention also relates to the use of antibodies to the antigen containing this epitope for diagnosis and monitoring of treatment of cancer and to the use of this antigen in the preparation of vaccines to elicit an immune response similar to that obtained against tumor cells containing this epitope.

Abstract: The present invention relates to an improved powder coating composition comprising (a) a resin, (b) a curing agent and (c) zinc, wherein the zinc is a mixture of (c1) lamellar zinc and (c2) zinc dust.

Abstract: Disclosed are sustained release dosage forms of liothyronine, in combination with normal or sustained release of thyroxine in a molar ratio of about 1 to 50:1, especially 5 to 20:1, useful in thyroid hormone replacement therapy. Surprisingly, it is found that by incorporating liothyronine and optionally thyroxine into a prolonged action dosage form in the described ratios, that the side effects associated with thyroid hormone replacement therapy are greatly reduced or eliminated. The preparation can be a dosage form containing salts of both thyroxine and liothyronine which release in a sustained manner. The preparations will typically contain 5 to 25 .mu.g of liothryronine. Also disclosed are processes of manufacturing the pharmaceutical preparations. The compositions are useful in treating disease states such as hypothyroidism, hyperthyroidism (in combination with thyrostatic drugs), so-called "TSH" suppressive therapy, and depression.

Abstract: In a process for chlorine-free bleaching of cellulose with an .alpha.-cellulose content of more than 90%, preferably from boiled cotton linters, more than 75% whiteness is achieved in a single-stage process using oxygen. The bleaching is conducted using the oxygen obtained by disproportionation of peroxo compounds in the pH range from 6 to 13 and with the bleaching time, depending on the bleaching temperature of 35.degree. C. to 15.degree. C., being between 15 and 150 minutes.

Abstract: Thermotropic liquid crystalline poly(ester-amide) compositions are disclosed which comprise a bis(4-carbonyl phenylene) terephthalate unit and a unit derived from an N-substituted hydrocarbylenediamine (e.g., one derived from an N,N-dialkylalkylene).

Abstract: .alpha.-aminonitrile compounds derived from a fatty alkyl alkylene diamine containing two reactible amino functionalities are disclosed.

Abstract: A method for attaching technetium-99m to proteins using reducing metal reagents to achieve binding to high affinity binding sites and high specific activity. The reagents play a dual role under the given experimental conditions by reducing disulfide bonds in the proteins to sulfhydral groups suitable for binding to technetium, and reducing pertechnetate from Tc(VII) to Tc(III) or Tc(V). Reduction of disulfide on the protein is conducted initially with an excess of reducing metal reagent, a pertechnetate reagent is added at the end of the protein reduction reaction and allowed to continue to reduce the technetium. Thereafter a chelator scavenger is added to remove poorly bound or unbound technetium.

Abstract: The present invention concerns a vaccine comprising a novel canine parvovirus strain and having the property of being able to break through the maternally derived antibody levels persistent in 9-12 week old pups, and even to immunize the majority of pups at the age of 6 weeks in the presence of maternally derived antibodies.

Abstract: The present application discloses a process for the production of agglomerates of peroxides that are solid at room temperature and which decompose rapidly when heated to their melting point. The process comprises agitating an aqueous suspension comprising a solid first peroxide which rapidly decomposes when heated to its melting point and a solid second peroxide which does not rapidly decompose when heated to its melting point and has a melting point which is substantially lower than the temperature at which said first peroxide rapidly decomposes, at a temperature sufficient to at least partially melt said second peroxide and below the decomposition temperature of said first peroxide to produce agglomerates comprised of said first and second peroxides; cooling with continued agitation the aqueous suspension having agglomerates to a temperature at which said second peroxide turns solid; and isolating the agglomerates.

Abstract: The present invention relates to non-resinous adsorbents and methods of manufacturing them. These agents have been found to neutralize or remove inhibitory and antimicrobial substances found in test samples and culture media.

Abstract: Glycosiduronic acids, such as alkyl glycosiduronic acids or alkenyl glycosiduronic acids, which may be used in the preparation of surfactant compositions, such as detergents and cleansers, are prepared by reacting an oxidized mono-, oligo-, or polysaccharide with up to 10 monomer units with one or more fatty alcohols having 8-22 carbon atoms in the presence of a catalyst, preferably in bulk, and after acetalization removing the excess alcohol. Preferably the oxidized mono-saccharide used is glucuronic acid and/or glucuronic acid-3,6-lactone.

Abstract: The addition of an aqueous solution containing one or more cations intended in a metal oxide ceramic product to a base to precipitate a calcinable metal oxide ceramic precursor reduces gelation problems during the precipitation of the precursor.

Abstract: Accelerator compositions for the free radical polymerization of unsaturated polyesters and for the curing of unsaturated polyesters and polyurethanes are disclosed. More particularly, use is made of complexes of thiolic compounds with metal salts as the accelerators. In more preferred embodiments, the accelerators also include oxygen-containing compounds or phosphorus-containing compounds. Also disclosed are curable resin compositions comprising these accelerators and polymerization and curing processes employing these accelerators.

Abstract: This invention relates to the field of immune therapy of cancer, more specifically to immunoconjugates of a cytotoxic moiety with a targeting moiety, more specifically to immunoconjugates of antibodies or fragments or functional derivatives of antibodies coupled to a cytotoxic substance such as drugs, toxins or radioisotopes. It especially relates to the release of substances bound to a targeting moiety through the use of acid-cleavable linker molecules.

Abstract: A polyoxime can be formed by reacting hydroxylamine with a copolymer of carbon monoxide and propylene. When the relative amount of oxime units in the polyoxime is high the polyoxime is soluble in water. Conversely, solubility in organic solvent is conferred when the oxime content is relatively low.

Abstract: The invention is a machine based alignment system for imaging with a contrasting marker (fiducial marker) attached to a support means for providing a set of markings which uniquely identify each cross-section of an imaged object in relation to other registered images.The invention also provides a method for using the alignment system.

Abstract: A hollow fiber bundle in which the hollow fibers are in the form of warp threads of woven hollow fiber tapes. The plurality of hollow fibers are held together by a low density, double weft thread. The hollow fiber bundles may form an angle with the lengthwise axis of the bundle such that adjacent woven hollow fiber tapes form an angle of intersection with one another or alternatively, the hollow fiber tapes may be made into partial bundles and the partial bundles assembled together so that the hollow fibers are arranged essentially parallel to one another and the lengthwise axis of the bundle. In both cases, the presence of weft threads ensures that the hollow fibers will not slide into the spaces between adjacent hollow fibers.

Abstract: The invention relates to bleaching granules containing a solid, water-insoluble peroxy acid and a hydratable inorganic material. The bleaching granules are made by a process wherein the constituents to be used are mixed to form a powder at low temperature and granules are formed from the powder as the temperature is increased to at least the hydration temperature of the hydratable inorganic material. The invention also relates to bleaching compositions and detergent compositions comprised of such bleaching granules.

Abstract: The invention concerns a method for detecting an analyte in a blood sample or a derived fraction thereof. In this method one uses the binding affinity between the analyte and its specific binding agent. Moreover, a reaction component containing a peroxidase label is added to the sample and specific binding agent to form a reaction mixture. The incubation of the reaction mixture, containing the analyte and its specific binding agent, with the peroxidase-labeled reaction component has to be carried out in the presence of a quaternary ammonium salt or ionic surfactant.