Patents Assigned to Alamak Biosciences Incorporation Company Limited
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Patent number: 10197479Abstract: Homogenous DNA or RNA cell blocks used as a standard and comprising uniformly distributed cells, or ratio of cells, for use as a positive control for a biomarker in immunohistochemistry slide scanning and image analysis. The cell blocks are made using a Homogenous Cell Mixture (HCM) apparatus comprising a rotating multi-tiers that de-clump and filter single cells downward to mix with a fixation liquid-3% agarose. The uniform rotation of the tiers is under the operational control of a motorized mechanism, and results in a cell mixture comprising a constant density of cells, which is then transferred into molds to make formalin fixed paraffin embedded (FFPE) cell blocks. The size of the molds is also determined based upon a computation that factors in the total number of cells (e.g. density) in a cell block that a user desires, and the total cell volume for a specific cell type selected.Type: GrantFiled: June 19, 2016Date of Patent: February 5, 2019Assignee: Alamak Biosciences Incorporation Company LimitedInventors: Pokman Chan, James Wang, Hok-Yu Chan
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Patent number: 10197569Abstract: An in vitro experimental standard comprising sections cut from a homogenous cell block for use as a positive control for biomarkers in immunohistochemistry experiments. The homogenous cell block is produced using a three layered vertical apparatus to create an evenly distributed suspension of FFPE cells, wherein the cells are mixed with 3% agarose while still rotating within the apparatus's middle layer. The injection of the cell mixture into a mold creates a homogeneous cell block where each cell, or ratio of different types of cells, is evenly distributed. The cell mixture within the cell block may further comprise: a mixture of the same type of cell with different genetic modifications; a mixture of the same type of cell with different protein or nucleic acids expression; and a mixture of different types of cells with different genetic backgrounds, and/or different expression level of genes and/or proteins.Type: GrantFiled: June 9, 2016Date of Patent: February 5, 2019Assignee: Alamak Biosciences Incorporation Company LimitedInventors: Pokman Chan, James Wang, Hok-Yu Chan
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Patent number: 10132729Abstract: A solid composition comprising a homogenous cell block able to be used as a positive control for biomarkers in immunohistochemistry experiments, such as slide scanning and image analysis. The homogenous cell block is produced using a three layered vertical apparatus to create an evenly distributed suspension of FFPE cells, wherein the cells are mixed with 3% agarose while still rotating within the apparatus's middle layer. The injection of the cell mixture into a mold creates a homogeneous cell block where each cell, or ratio of different types of cells, is evenly distributed. The cell mixture within the cell block may further comprise: a mixture of the same type of cell with different genetic modifications; a mixture of the same type of cell with different protein or nucleic acids expression; and a mixture of different types of cells with different genetic backgrounds, and/or different expression level of genes and/or proteins.Type: GrantFiled: June 9, 2016Date of Patent: November 20, 2018Assignee: Alamak Biosciences Incorporation Company LimitedInventors: Pokman Chan, James Wang, Hok-Yu Chan
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Patent number: 9395283Abstract: An in vitro method of making a homogenous cell block for use as a positive control for biomarkers in immunohistochemistry experiments, such slide scanning and image analysis. The homogenous cell block is produced using a three layered vertical apparatus to create an evenly distributed suspension of FFPE cells, wherein the cells are mixed with 3% agarose while still rotating within the apparatus's middle layer. The injection of the cell mixture into a mold creates a homogeneous cell block where each cell, or ratio of different types of cells, is evenly distributed. The cell mixture within the cell block may comprise: a mixture of the same type of cell with different genetic modifications; a mixture of the same type of cell with different protein or nucleic acids expression; and a mixture of different types of cells with different genetic backgrounds, and/or different expression level of genes and/or proteins.Type: GrantFiled: March 13, 2013Date of Patent: July 19, 2016Assignee: Alamak Biosciences Incorporation Company LimitedInventors: Pokman Chan, James Wang, Hok-Yu Chan
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Patent number: D734483Type: GrantFiled: December 31, 2013Date of Patent: July 14, 2015Assignee: Alamak Biosciences Incorporation Company LimitedInventors: Pokman Chan, James Wang, Hok-Yu Chan
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Patent number: D739549Type: GrantFiled: December 31, 2013Date of Patent: September 22, 2015Assignee: Alamak Biosciences Incorporation Company LimitedInventors: Pokman Chan, James Wang, Hok-Yu Chan
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Patent number: D815296Type: GrantFiled: August 4, 2015Date of Patent: April 10, 2018Assignee: Alamak Biosciences Incorporation Company LimitedInventors: Pokman Chan, James Wang, Hok-Yu Chan
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Patent number: D815297Type: GrantFiled: August 4, 2015Date of Patent: April 10, 2018Assignee: Alamak Biosciences Incorporation Company LimitedInventors: Pokman Chan, James Wang, Hok-Yu Chan
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Patent number: D815748Type: GrantFiled: August 4, 2015Date of Patent: April 17, 2018Assignee: Alamak Biosciences Incorporation Company LimitedInventors: Pokman Chan, James Wang, Hok-Yu Chan
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Patent number: D815749Type: GrantFiled: August 4, 2015Date of Patent: April 17, 2018Assignee: Alamak Biosciences Incorporation Company LimitedInventors: Pokman Chan, James Wang, Hok-Yu Chan
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Patent number: D815750Type: GrantFiled: August 4, 2015Date of Patent: April 17, 2018Assignee: Alamak Biosciences Incorporation Company LimitedInventors: Pokman Chan, James Wang, Hok-Yu Chan