Patents Assigned to ALCOBRA LTD.
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Patent number: 9931303Abstract: The present invention relates generally to abuse-deterrent formulations containing dextroamphetamine sulfate.Type: GrantFiled: May 10, 2017Date of Patent: April 3, 2018Assignee: Alcobra Ltd.Inventors: Yaron Daniely, David Baker, Hanna Ron, David Siner
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Patent number: 9851355Abstract: The present invention relates generally to methods of determining the response to metadoxine therapy for the treatment of Fragile X Syndrome and other cognitive disorders. The invention also relates to identifying individuals that will be responsive to metadoxine therapy.Type: GrantFiled: September 9, 2014Date of Patent: December 26, 2017Assignee: Alcobra Ltd.Inventors: Yaron Daniely, Jonathan Rubin, Johanna Schumann
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Patent number: 9851354Abstract: The present invention provides methods of alleviating a sign or a symptom of Fragile X Syndrome and relates disorders such as autism spectrum disorders.Type: GrantFiled: September 9, 2014Date of Patent: December 26, 2017Assignee: Alcobra Ltd.Inventors: Yaron Daniely, Dalia Megiddo
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Patent number: 9808446Abstract: The present invention relates to methods and compositions of metadoxine and physiologically compatible active derivatives thereof, and their use for decreasing symptoms of alcohol consumption as well as in the prevention of alcohol consumption related symptoms in subjects in need thereof.Type: GrantFiled: April 3, 2015Date of Patent: November 7, 2017Assignee: Alcobra Ltd.Inventors: Gur Megiddo, Dalia Megiddo, Rina Yamin, Yaron Ilan, Shimon Amselem
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Patent number: 9428458Abstract: The present invention provides salt adducts comprising at least one positively charged moiety being a pyridoxine or a derivative thereof and at least one carboxylated 5- to 7-membered lactam ring, optionally additionally substituted, methods of their preparation, and pharmaceutical compositions and medicaments comprising them. Salt adducts of the invention and compositions comprising them may be used to in the treatment of diseases or disorders associated with or inflicted by alcohol consumption.Type: GrantFiled: October 3, 2014Date of Patent: August 30, 2016Assignee: ALCOBRA LTD.Inventors: Rina Yamin, Dalia Megiddo
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Patent number: 8889715Abstract: The present invention provides salt adducts comprising at least one positively charged moiety being a pyridoxine or a derivative thereof and at least one carboxylated 5- to 7-membered lactam ring, optionally additionally substituted, methods of their preparation, and pharmaceutical compositions and medicaments comprising them. Salt adducts of the invention and compositions comprising them may be used to in the treatment of diseases or disorders associated with or inflicted by alcohol consumption.Type: GrantFiled: November 2, 2012Date of Patent: November 18, 2014Assignee: Alcobra Ltd.Inventors: Rina Yamin, Dalia Megiddo
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Patent number: 8710067Abstract: The present invention provides uses of a salt adduct comprising at least one positively charged moiety being a pyridoxine or a derivative thereof and at least one carboxylated 5- to 7-membered lactam ring, optionally additionally substituted, for the preparation of a medicament for the treatment, alleviation of symptoms of, relieving, improving and preventing a cognitive disease, disorder or condition in a subject. Additionally, the invention provides use of said salt adducts for the preparation of medicaments for the improvement of cognitive functions in a healthy subject.Type: GrantFiled: July 3, 2012Date of Patent: April 29, 2014Assignee: Alcobra Ltd.Inventors: Rina Yamin, Dalia Megiddo, Yaron Ilan
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Patent number: 8476304Abstract: The present invention relates to methods and compositions of metadoxine and physiologically compatible active derivatives thereof, and their use for decreasing symptoms of alcohol consumption as well as in the prevention of alcohol consumption related symptoms in subjects in need thereof.Type: GrantFiled: July 3, 2012Date of Patent: July 2, 2013Assignee: Alcobra Ltd.Inventors: Gur Megiddo, Dalia Megiddo, Rina Yamin, Yaron Ilan, Shimon Amselem
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Publication number: 20130059887Abstract: The present invention provides salt adducts comprising at least one positively charged moiety being a pyridoxine or a derivative thereof and at least one carboxylated 5- to 7-membered lactam ring, optionally additionally substituted, methods of their preparation, and pharmaceutical compositions and medicaments comprising them. Salt adducts of the invention and compositions comprising them may be used to in the treatment of diseases or disorders associated with or inflicted by alcohol consumption.Type: ApplicationFiled: November 2, 2012Publication date: March 7, 2013Applicant: ALCOBRA LTD.Inventor: Alcobra Ltd.
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Publication number: 20130012549Abstract: The present invention provides uses of a salt adduct comprising at least one positively charged moiety being a pyridoxine or a derivative thereof and at least one carboxylated 5- to 7-membered lactam ring, optionally additionally substituted, for the preparation of a medicament for the treatment, alleviation of symptoms of, relieving, improving and preventing a cognitive disease, disorder or condition in a subject. Additionally, the invention provides use of said salt adducts for the preparation of medicaments for the improvement of cognitive functions in a healthy subject.Type: ApplicationFiled: July 3, 2012Publication date: January 10, 2013Applicant: Alcobra Ltd.Inventors: Rina Yamin, Dalia Megiddo, Yaron Ilan
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Publication number: 20120277270Abstract: The present invention relates to methods and compositions of metadoxine and physiologically compatible active derivatives thereof, and their use for decreasing symptoms of alcohol consumption as well as in the prevention of alcohol consumption related symptoms in subjects in need thereof.Type: ApplicationFiled: July 3, 2012Publication date: November 1, 2012Applicant: Alcobra Ltd.Inventors: Gur Megiddo, Dalia Megiddo, Rina Yamin, Yaron Ilan, Shimon Amselem
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Publication number: 20110294859Abstract: The present invention provides salt adducts comprising at least one positively charged moiety being a pyridoxine or a derivative thereof and at least one carboxylated 5- to 7-membered lactam ring, optionally additionally substituted, methods of their preparation, and pharmaceutical compositions and medicaments comprising them. Salt adducts of the invention and compositions comprising them may be used to in the treatment of diseases or disorders associated with or inflicted by alcohol consumption.Type: ApplicationFiled: July 29, 2009Publication date: December 1, 2011Applicant: ALCOBRA LTD.Inventors: Rina Yamin, Dalia Megiddo
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Publication number: 20100256198Abstract: The present invention relates to methods and compositions of metadoxine and physiologically compatible active derivatives thereof, and their use for decreasing symptoms of alcohol consumption as well as in the prevention of alcohol consumption related symptoms in subjects in need thereof.Type: ApplicationFiled: July 3, 2008Publication date: October 7, 2010Applicant: ALCOBRA LTD.Inventors: Gur Megiddo, Dalia Megiddo, Rina Yamin, Yaron Ilan, Shimon Amselem