Patents Assigned to Alembic Limited
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Publication number: 20110306796Abstract: The present invention relates to an improved process for the preparation of 1-bromo-3,5-dimethyl adamantane of formula (III), which is an useful intermediate for synthesis of 1-amino-3,5-dimethyl adamantane of formula (I) or pharmaceutically acceptable salt thereof.Type: ApplicationFiled: November 30, 2009Publication date: December 15, 2011Applicant: ALEMBIC LIMITEDInventors: Ravi Ponnaiah, Ashok Prasad, Piyush Maheshbhai Rana, Kamlesh Shankarlal Kanzariya, Mitulkumar Bharatkumar Dolia
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Publication number: 20110230657Abstract: The present invention relates to an improved process for preparing Quetiapine fumarate of formula (I).Type: ApplicationFiled: November 30, 2009Publication date: September 22, 2011Applicant: ALEMBIC LIMITEDInventors: Ravi Ponnaiah, Ashok Prasad, Dineshkumar Ramabhai Panchasara, Mitul Bipinchandra Patwa, Ketan Bharatendubhai Patel
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Publication number: 20110230663Abstract: The present invention relates to novel process for preparing Donepezil hydrochloride of formula (I)Type: ApplicationFiled: November 30, 2009Publication date: September 22, 2011Applicant: ALEMBIC LIMITEDInventors: Ravi Ponnaiah, Ashok Prasad, Dineshkumar Ramabhai Panchasara, Gajanan Jijaba Chavan, Bhavesh Hareshbhai Prajapati, Ilesh Mahendrabhai Patel
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Patent number: 7968731Abstract: An improved process is described for the purification of ropinirole hydrochloride. The process includes (i) dissolving ropinirole hydrochloride in water; (ii) treating the solution obtained in step (i) with sodium dithionate and charcoal; (iii) treating the filtrate obtained in step (ii) with water immiscible solvent and base and isolating the free base; and (iv) treating the free base obtained in step (iii) with ethanolic HCl to give ropinirole hydrochloride.Type: GrantFiled: March 21, 2007Date of Patent: June 28, 2011Assignee: Alembic LimitedInventors: Pandurang Balwant Deshpande, Ashok Prataprai Shanishchara, Trushar Rajanikant Shah, Hitarth Harshendu Acharya, Parven Kumar Luthra
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Publication number: 20110092727Abstract: The present invention relates to a process for preparing Teriflunomide of formula (I).Type: ApplicationFiled: June 3, 2009Publication date: April 21, 2011Applicant: ALEMBIC LIMITEDInventors: Keshav Deo, Samir Patel, Snehal Dhol, Sunil Sanghani, Vishal Ray
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Patent number: 7923567Abstract: The invention relates to novel compound of formula (IV), which is an organic acid salt of N-[(2?-cyanobiphenyl-4-yl)methyl]-(L)-valine ester. This compound is an useful intermediate for process of preparation of Valsartan of formula (I), chemically known as (S)-N-(1-Carboxy-2-methylprop-1-yl)-N-pentanoyl-N-[2?-(1H-terazol-5-yl)biphenyl-4-ylmethyl]amine. This invention also relates to a process for preparing Valsartan using novel intermediate of formula (IV).Type: GrantFiled: June 15, 2010Date of Patent: April 12, 2011Assignee: Alembic LimitedInventors: Rohit Ravikant Soni, Sanjay Lakhabhai Vasoya, Ravindra Charudatta Ghotikar, Anand Kumar Pandey, Hetal Remeshchandra Shah
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Patent number: 7863462Abstract: The present invention provides an improved process for the purification of ropinirole hydrochloride. The process includes (i) treating ropinirole hydrochloride with sodium dithionate and charcoal in suitable alcoholic solvent; (ii) triturating the ropinirole hydrochloride obtained in step (i) with ethanol; (iii) reacting the triturated solid with base in water immiscible solvent and isolating the free base; and (iv) treating the free base obtained in step (iii) with ethanolic HCl to give ropinirole hydrochloride.Type: GrantFiled: March 21, 2007Date of Patent: January 4, 2011Assignee: Alembic LimitedInventors: Pandurang Balwant Deshpande, Parven Kumar Luthra, Hitarth Harshendu Acharya
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Publication number: 20100310652Abstract: An extended release pharmaceutical composition comprising levetiracetam. A coated extended release pharmaceutical composition comprising levetiracetam wherein the core is coated with a rate controlling composition.Type: ApplicationFiled: December 22, 2008Publication date: December 9, 2010Applicant: Alembic LimitedInventors: Rajesh Kshirsagar, Ashwin Rao, Atul Kathiriya
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Patent number: 7807195Abstract: The present invention relates to an extended release once daily pharmaceutical formulation comprising venlafaxine hydrochloride and pharmaceutically acceptable excipients. More particularly, the present invention relates to an extended release composition in the form of mini-tablets which are incorporated in hard gelatin capsules.Type: GrantFiled: January 7, 2005Date of Patent: October 5, 2010Assignee: Alembic LimitedInventors: Sampad Bhattacharya, Rajesh Kshirsagar, Mayank Joshi, Sandeep Pandita
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Publication number: 20100249430Abstract: The invention relates to novel compound of formula (IV), which is an organic acid salt of N-[(2?-cyanobipheny1-4-yl)methyl]-(L)-valine ester. This compound is an useful intermediate for process of preparation of Valsartan of formula (I), chemically known as (S)-N-(1-Carboxy-2-methylprop-1-yl)-N-pentanoyl-N-[2?-(1H-terazol-5-yl)biphenyl-4-ylmethyl]amine. This invention also relates to a process for preparing Valsartan using novel intermediate of formula (IV).Type: ApplicationFiled: June 15, 2010Publication date: September 30, 2010Applicant: ALEMBIC LIMITEDInventors: Rohit Ravikant Soni, Sanjay Lakhabhai Vasoya, Ravindra Charudatta Ghotikar, Anand Kumar Pandey, Hetal Remeshchandra Shah
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Publication number: 20100249433Abstract: An improved process is described for the purification of ropinirole hydrochloride. The process includes (i) dissolving ropinirole hydrochloride in water; (ii) treating the solution obtained in step (i) with sodium dithionate and charcoal; (iii) treating the filtrate obtained in step (ii) with water immiscible solvent and base and isolating the free base; and (iv) treating the free base obtained in step (iii) with ethanolic HCl to give ropinirole hydrochloride.Type: ApplicationFiled: March 21, 2007Publication date: September 30, 2010Applicant: ALEMBIC LIMITEDInventors: Pandurang Balwant Deshpande, Ashok Prataprai Shanishchara, Trushar Rajanikant Shah, Hitarth Harshendu Acharya, Parven Kumar Luthra
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Publication number: 20100210852Abstract: The present invention relates to an improved process for the preparation of tritylated candesartan acid of formula (I) comprising a step of, reacting candesartan acid of formula (II) with trityl chloride in the presence of a base in a ketonic solvent.Type: ApplicationFiled: August 30, 2007Publication date: August 19, 2010Applicant: Alembic LimitedInventors: Keshav Deo, Sanjay Desai, Dhiraj Mohansinh Rathod, Lalitkumar Keshavial Katariya, Nilesh Vashrambhai Bhimani
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Patent number: 7777039Abstract: The present invention relates to an improved process for the preparation of 7-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy]-1,2,3,4-tetrahydroquinolin-2-one (Aripiprazole) having dimer impurity less than 0.15%, particularly, the present invention relates to an improved process for the preparation of 7-(4-chlorobutoxy)-3,4-dihydrocarbostyril of formula (I) having dimer impurity less than 0.5% which includes a step of reacting 7-hydroxy-tetrahydroquinolinone of formula (III) with 1-bromo-4-chlorobutane in the presence of a base in a solvent.Type: GrantFiled: June 7, 2006Date of Patent: August 17, 2010Assignee: Alembic LimitedInventors: Pandurang Balwant Deshpande, Parven Kumar Luthra, Ashok Prataprai Shanishchara, Ramesh Manepalli, Dharmesh Balvantrai Mistry
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Publication number: 20100179332Abstract: The present invention provides an improved process for the purification of ropinirole hydrochloride. The process includes (i) treating ropinirole hydrochloride with sodium dithionate and charcoal in suitable alcoholic solvent; (ii) triturating the ropinirole hydrochloride obtained in step (i) with ethanol; (iii) reacting the triturated solid with base in water immiscible solvent and isolating the free base; and (iv) treating the free base obtained in step (iii) with ethanolic HCl to give ropinirole hydrochloride.Type: ApplicationFiled: March 21, 2007Publication date: July 15, 2010Applicant: Alembic LimitedInventors: Pandurang Balwant Deshpande, Parven Kumar Luthra, Hitarth Harshendu Acharya
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Patent number: 7741507Abstract: The invention relates to novel compound of formula (IV), which is an organic acid salt of N-[(2?-cyanobiphenyl-4-yl)methyl]-(L)-valine ester. This compound is an useful intermediate for process of preparation of Valsartan of formula (I), chemically known as (S)—N-(1-Carboxy-2-methylprop-1-yl)-N-pentanoyl-N-[2?-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]amine. This invention also relates to a process for preparing Valsartan using novel intermediate of formula (IV).Type: GrantFiled: July 24, 2006Date of Patent: June 22, 2010Assignee: Alembic LimitedInventors: Rohit Ravikant Soni, Sanjay Lakhabhai Vasoya, Ravindra Charudatta Ghotikar, Anand Kumar Pandey, Hetal Remeshchandra Shah
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Patent number: 7741477Abstract: The present invention relates to a process for the purification of Sucralose of formula (I) which comprises acetylation of substantially impure Sucralose to its penultimate intermediate 4,1?,6?-trichloro-4,1?,6?-trideoxy galactosucrose penta-acetate (TOPSA) of formula (VI) followed by purification of TOPSA and then deacetylation of purified TOPSA.Type: GrantFiled: January 10, 2007Date of Patent: June 22, 2010Assignee: Alembic LimitedInventors: Pandurang Balwant Deshpande, Parven Kumar Luthra, Sanjiv Onkarsingh Tomer, Piyush Maheshbhai Rana, Jigar Kamleshbhai Patel
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Publication number: 20100113798Abstract: A process for the preparation of Irbesartan of formula (I) using the step of, reacting biphenyl derivative of formula (VIa) wherein R represents a group selected from —CONH2 or compound of formula wherein X represents H or C1-4 alkyl, preferably methyl; or any other such group which can be converted to cyano group, with 1-veleramido cyclopentane carboxylic acid of formula (V) in the presence of an acid in an organic solvent to give biphenyl derivative of formula (VIIa) wherein R has the same meaning as mentioned hereinabove.Type: ApplicationFiled: January 7, 2010Publication date: May 6, 2010Applicant: ALEMBIC LIMITEDInventors: Pandurang Balwant Deshpande, Parven Kumar Luthra, Dhiraj Mohansinh Rathod, Hitesh Kantilal Patel, Pinky Tarak Parikh
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Patent number: 7683205Abstract: The present invention relates to an improved process for preparation of Rivastigmine of formula (I) or pharmaceutically acceptable salts thereof comprising a step of N-methylation of compound of formula (III), wherein R1=R2=H or R1=H and R2=CH3 or an acid addition salt thereof, using paraformaldehyde in the presence of Raney Nickel and hydrogen in a suitable solvent to obtain compound of formula (II).Type: GrantFiled: October 31, 2006Date of Patent: March 23, 2010Assignee: Alembic LimitedInventors: Pandurang Balwant Deshpande, Kishore Khemani, Bharat Becharbhai Boda, Tushar Rajnikant Shah, Hitarth Harshendu Acharya, Parven Kumar Luthra
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Patent number: 7652147Abstract: A process for the preparation of Irbesartan of formula (I) using the steps of: (i) reacting 4? aminomethyl-2-cyano biphenyl of formula (VI) with 1-veleramido cyclopentane carboxylic acid of formula (V) in an organic solvent and in the presence of an acid, without activating the —COOH group of compound of formula (V) to give 1-(2?cyanobiphenyl-4-yl-methylaminocarbonyl)-1-pentanoylamino cyclopentane of formula (VII). converting the compound of formula (VII) obtained in step (i) to Irbesartan of formula (I) by reacting the compound of the formula (VII) with tributyl tin azide in o-xylene to give Irbesartan of formula (I).Type: GrantFiled: April 19, 2006Date of Patent: January 26, 2010Assignee: Alembic LimitedInventors: Pandurang Balwant Deshpande, Parven Kumar Luthra, Dhiraj Mohansinh Rathod, Hitesh Kantilal Patel, Pinky Tarak Parikh
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Publication number: 20090312538Abstract: The present invention relates to an improved process for the preparation of Sucralose having purity of at least 99.6% comprising steps of (i) dissolving substantially impure Sucralose in water (ii) treating the solution obtained in step (i) with a partially water immiscible solvent (iii) washing the said solvent phase obtained in step (ii) with an amount of water sufficient to remove polar impurities (iv) crystallizing the product from partially water immiscible solvent (v) recrystallizing the solid obtained in step (iv) from water.Type: ApplicationFiled: October 19, 2006Publication date: December 17, 2009Applicant: Alembic LimitedInventors: Pandurang Balwant Deshpande, Parven Kumar Luthra, Sanjiv Onkarsingh Tomer, Kashyap Ravindrabhai Wadekar, Piyush Maheshbhai Rana, Kamlesh Shankarlal Kanzariya