Patents Assigned to Alere International
  • Methods and Compositions for Monitoring and Risk Prediction in Cardiorenal Syndrome
    Publication number: 20110104726
    Abstract: The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects. In particular, the invention relates to methods and compositions selected to monitor cardiorenal syndrome using assays that detect NGAL, preferably together with assays that detect natriuretic peptides such as BNP. Such methods and compositions can provide early indications of a deterioration in cardiorenal syndrome status, including prognosis regarding mortality and worsening renal function.
    Type: Application
    Filed: October 21, 2010
    Publication date: May 5, 2011
    Applicant: Alere International
    Inventors: Gunars Valkirs, Paul H. McPherson
  • Arginine analogs, and methods for their synthesis and use
    Patent number: 7879979
    Abstract: The present invention relates to novel arginine analogs, and methods for their synthesis and use. Such analogs are designed to provide a protected or free thiol (—SH) group, thereby providing a convenient linkage chemistry for coupling to a suitable group on a target such as a protein, polypeptide, detectable label or solid phase, and at a site distal to the guanidino group. Arginine analog conjugates are useful for generating antibodies that can bind specifically with dimethylarginine, which can be detected using such antibodies in immunoassays.
    Type: Grant
    Filed: January 19, 2006
    Date of Patent: February 1, 2011
    Assignee: Alere International
    Inventors: Kenneth F. Buechler, Mariusz G. Banaszczyk, Joseph Barry Noar, Violeta Dinauer
  • Benzothiazinone derivatives and their use as antibacterial agents
    Patent number: 7863268
    Abstract: Disclosed are benzothiazin derivatives of formula (I), preparation methods therefore, and treatment methods employing such compounds as antibacterial agents in treating infectious diseases of mammals caused by bacteria, especially diseases like tuberculosis and leprosy caused by mycobacteria: wherein R1, R2, R3, R4, R5, and R6, and other variables enumerated under one or more of R1, R2, R3, R4, R5, and R6 are as defined.
    Type: Grant
    Filed: May 24, 2006
    Date of Patent: January 4, 2011
    Assignee: Alere International
    Inventors: A. Vadim Makarov, Stewart T. Cole, Ute Moellmann
  • Methods and compositions for monitoring and risk prediction in cardiorenal syndrome
    Patent number: 7842472
    Abstract: The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects. In particular, the invention relates to methods and compositions selected to monitor cardiorenal syndrome using assays that detect NGAL, preferably together with assays that detect natriuretic peptides such as BNP. Such methods and compositions can provide early indications of a deterioration in cardiorenal syndrome status, including prognosis regarding mortality and worsening renal function.
    Type: Grant
    Filed: November 14, 2007
    Date of Patent: November 30, 2010
    Assignee: Alere International
    Inventors: Gunars Valkirs, Paul H. McPherson