Patents Assigned to Alfama-Investigacao e Desenvolvimento de Produtos Farmaceuticos Lda
  • RUTHENIUM CARBON MONOXIDE RELEASING MOLECULES AND USES THEREOF
    Publication number: 20140219996
    Abstract: The present invention provides novel ruthenium compounds of Formula (I): or salts, isomers, hydrates, or solvates thereof, or combinations thereof; wherein E, R1, R2, R3, R4, R5, X1, and X2 are as defined herein, and pharmaceutical compositions thereof. Also provided are methods of use and treatment. Such compounds have been found useful in the treatment of malaria infection. Such compounds may also be useful in the treatment of inflammatory conditions, such as acute lung injury and acute respiratory distress syndrome, which optionally may be associated with a malaria infection.
    Type: Application
    Filed: July 20, 2012
    Publication date: August 7, 2014
    Applicant: ALFAMA- Investigacao e Desenvolvimento de Produtos Farmacêuticos, Lda.
    Inventors: Ana Pamplona, Gonçalo J.L. Bernardes, Maria M. Mota, Carlos C. Romão
  • PREVENTION OF GASTRIC ULCER BY CARBON MONOXIDE
    Publication number: 20140212514
    Abstract: The invention relates to the use of carbon monoxide (CO) to inhibit the gastrointestinal side effects caused by non-steroidal anti-inflammatory drugs (NSAIDs) and/or alcohol.
    Type: Application
    Filed: October 11, 2013
    Publication date: July 31, 2014
    Applicant: ALFAMA - Investigacao e Desenvolvimento de Produtos Farmaceuticos, Lda.
    Inventors: Sandra Sofia Pereira Rodrigues, Joaõ D. Seixas, Bruno Guerreiro, Nuno Miguel Penacho Pereira, Carlos C. Romão, Werner E. Haas, Isabel Goncalves
  • PREVENTION OF GASTRIC ULCER BY CARBON MONOXIDE
    Publication number: 20110038955
    Abstract: The invention relates to the use of carbon monoxide (CO) to inhibit the gastrointestinal side effects caused by non-steroidal anti-inflammatory drugs (NSAIDs) and/or alcohol.
    Type: Application
    Filed: July 24, 2008
    Publication date: February 17, 2011
    Applicant: ALFAMA - Investigacao e Desenvolvimento de Produtos Farmaceuticos, Lda.
    Inventors: Sandra S. Rodrigues, Joao D. Seixas, Bruno Guerreiro, Nuno Miguel Penacho Pereira, Carlos C. Romao, Werner E. Haas, Isabel Maria de Sousa Goncalves
  • TREATMENT OF INFECTIONS BY CARBON MONOXIDE
    Publication number: 20100196516
    Abstract: The invention relates to the use of carbon monoxide (CO) to treat infections. The invention also provides novel carbon monoxide releasing molecules (CORMs).
    Type: Application
    Filed: April 24, 2008
    Publication date: August 5, 2010
    Applicant: ALFAMA-Investigacao e Desenvolvimento de produtos Farmaceuticos, Lda
    Inventors: Ligia S. Nobre, Joao D. Seixas, Carlos C. Romao, Ligia M. Saraiva
  • Method for treating a mammal by administration of a compound having the ability to release CO
    Publication number: 20060233890
    Abstract: Several classes of in vivo carbon monoxide-releasing compounds are useful for the treatment and/or prevention of diseases, such as chronic inflammatory, e.g., rheumatoid arthritis, and of diseases with a strong inflammatory component, such as atherosclerosis, stroke, coronary disease, and Alzheimers disease. The in vivo carbon monoxide-releasing compounds can be attached to known drug vectors and/or known anti-inflammatory drugs, such as aspirin.
    Type: Application
    Filed: June 14, 2006
    Publication date: October 19, 2006
    Applicant: Alfama - Investigacao e Desenvolvimento de Produtos Farmaceuticos Lda
    Inventors: Werner Haas, Carlos Romao, Beatriz Royo, Ana Fernandes, Isabel Goncalves
  • Method for treating a mammal by administration of a compound having the ability to release CO, compounds having the ability to release CO and pharmaceutical compositions thereof
    Publication number: 20060148900
    Abstract: Several classes of in vivo carbon monoxide-releasing compounds are useful for the treatment and/or prevention of diseases, such as chronic inflammatory, e.g., rheumatoid arthritis, and of diseases with a strong inflammatory component, such as atherosclerosis, stroke, coronary disease, and Alzheimers disease. The in vivo carbon monoxide-releasing compounds can be attached to known drug vectors and/or known anti-inflammatory drugs, such as aspirin.
    Type: Application
    Filed: November 29, 2005
    Publication date: July 6, 2006
    Applicant: Alfama - Investigacao e Desenvolvimento de Produtos Farmaceuticos Lda
    Inventors: Werner Haas, Carlos Romao, Beatriz Royo, Ana Fernandes, Isabel Goncalves
  • Method for treating a mammal by administration of a compound having the ability to release CO, compounds having the ability to release CO and pharmaceutical compositions thereof
    Patent number: 7011854
    Abstract: Several classes of in vivo carbon monoxide-releasing compounds are useful for the treatment and/or prevention of diseases, such as chronic inflammatory, e.g., rheumatoid arthritis, and of diseases with a strong inflammatory component, such as atherosclerosis, stroke, coronary disease, and Alzheimers disease. The in vivo carbon monoxide-releasing compounds can be attached to known drug vectors and/or known anti-inflammatory drugs, such as aspirin.
    Type: Grant
    Filed: February 3, 2003
    Date of Patent: March 14, 2006
    Assignee: Alfama-Investigacao e Desenvolvimento de Produtos Farmaceuticos Lda
    Inventors: Werner Haas, Carlos Romao, Beatriz Roya, Ana Cristina Fernandes, Isabel Goncalves