Abstract: Systems and methods for monitoring blood flow metrics using a patch of a flexible substrate configured to attach to an area of skin over a blood vessel. The patch includes a plurality of light sources arranged on the substrate to form a matrix and a row of photodetectors disposed on the substrate substantially in parallel with the rows of LEDs. The patch includes an optical signal interface configured to drive each light source and to input an intensity signal at one of the photodetectors. The intensity signals are used to determine AC and DC components corresponding to each optical path. AC to DC component ratios are calculated for each optical path and used to determine ratio-of-ratio values. At least a subset of the ratio-of-ratio values are used to determine a biological metric or a cross-sectional area of the blood vessel.

Abstract: A system, device and method for measuring markers for a periprosthetic joint infection in a sample of synovial fluid. A sensor reader device includes a vial receptacle for receiving a vial containing synovial fluid. A light source illuminates the vial and an optical sensor detects light scattered and/or absorbed by white blood cells in the fluid sample. An electrical signal corresponding to the intensity of the light received at the optical sensor is detected. A white blood cell concentration is determined from the electrical signal value. The sensor reader device also includes one or more immunoassay strip receptacles. Immunoassay strips for other marker are inserted into the receptacles. Immunoassay optical sensors detect light generated by the immunoassay reaction on the immunoassay strip to determine the concentration of the marker. In example implementations, the device includes an immunoassay strip reader for leukocyte esterase and c-reactive protein.

Abstract: Systems and methods for monitoring blood flow metrics using a patch of a flexible substrate configured to attach to an area of skin over a blood vessel. The patch includes a plurality of light sources arranged on the substrate to form a matrix and a row of photodetectors disposed on the substrate substantially in parallel with the rows of LEDs. The patch includes an optical signal interface configured to drive each light source and to input an intensity signal at one of the photodetectors. The intensity signals are used to determine AC and DC components corresponding to each optical path. AC to DC component ratios are calculated for each optical path and used to determine ratio-of-ratio values. At least a subset of the ratio-of-ratio values are used to determine a biological metric or a cross-sectional area of the blood vessel.

Abstract: A prosthesis for monitoring a characteristic of flow includes a first tubular prosthesis having a lumen and a sensor for detecting the characteristic of flow through the lumen. The sensor may be covered with another tubular prosthesis or by a layer of material ire order to insulate the sensor from the fluid flow. A pocket may be formed between the tubular prosthesis and the adjacent layer of material or prosthesis and the sensor may be disposed in the pocket.

Abstract: A prosthesis for monitoring a characteristic of flow includes a first tubular prosthesis having a lumen and a sensor for detecting the characteristic of flow through the lumen. The sensor may be covered with another tubular prosthesis or by a layer of material in order to insulate the sensor from the fluid flow. A pocket may be formed between the tubular prosthesis and the adjacent layer of material or prosthesis and the sensor may be disposed in the pocket.

Abstract: A system, device and method for automatically and remotely acquiring sensor data from a wearable patch mounted on a patient. An example device implemented as a wearable patch includes a sensor assembly comprising a plurality of sensors configured to detect a corresponding plurality of sensory modalities and generate electrical signals representing the sensory modalities. A signal converter receives the electrical signals from the plurality of sensors and converts the signals to sensor data signals comprising a data representation of at least one of the electrical signals. A communications interface communicates the sensor data signals to a sensor data processing system.

Abstract: A system and methodology for distributed delivery of online content in response to client selections from an online catalog is described. In one embodiment, for example, a system of the present invention is described for receiving and playing movies, the system comprises: a personal computer with Internet connectivity and having a browser for selecting movies from an online catalog; a set-top box with Internet connectivity, the set-top box having a hard disk for storing encrypted copies of the selected movies that the set-top box receives in response to user selections from the online catalog; and a television device, connected to the set-top box, for playing back decrypted copies of the selected movies that have been purchased for playback.

Abstract: A distributed system and methodology for delivery of media content is described. In one embodiment, for example, a method of the present invention is described for distributing media comprises: receiving at a server a request from a first client for a particular media item, the first client having broadband connectivity to other clients; at the server, determining a second client who has an encrypted copy of the desired media item; transferring the encrypted copy of the desired media item from the second client to the first client; after the encrypted copy has been transferred to the first client, indicating at the first client that the desired media item is now available; and in response to receiving payment authorization from the first client, decrypting the desired media item for use at the first client.

Abstract: A distributed system and methodology for delivery of media content to clients having peer-to-peer connectivity is described. In one embodiment, for example, a method of the present invention is described for distributing media comprises: receiving at a server a request from a first client for a particular media item, the first client having broadband connectivity to other clients; at the server, determining a second client who has an encrypted copy of the desired media item; transferring the encrypted copy of the desired media item from the second client to the first client; after the encrypted copy has been transferred to the first client, indicating at the first client that the desired media item is now available; and in response to receiving payment authorization from the first client, decrypting the desired media item for use at the first client.

Abstract: A system and methodology for distributed delivery of online content in response to client selections from an online catalog is described. In one embodiment, for example, a system of the present invention is described for receiving and playing movies, the system comprises: a personal computer with Internet connectivity and having a browser for selecting movies from an online catalog; a set-top box with Internet connectivity, the set-top box having a hard disk for storing encrypted copies of the selected movies that the set-top box receives in response to user selections from the online catalog; and a television device, connected to the set-top box, for playing back decrypted copies of the selected movies that have been purchased for playback.