Abstract: A method of making an intraocular lens including providing a fixation member having a proximal end portion with the proximal end portion including an elongated filament, converting a region of said filament at said proximal end portion from a first configuration into a second configuration which is adapted to provide a mechanical interlock and molding an optic about the proximal end portion of the fixation member to form a mechanical interlock between the second configuration and the optic and to attach the fixation member to the optic.

Abstract: Compositions and methods useful for enhancing the transdermal and transmembrane drug delivery of topical and systemic agents. The compositions and methods comprise the active agent together with an effective amount of certain amides of heterocyclic amines as defined herein as penetration enhancers and topically administering to human or animal skin or other membranes the resulting compositions.

Abstract: A one step method for cleaning and disinfecting contact lenses is accomplished by immersing the lenses in a solution containing peroxide and a peroxide-active enzyme.

Abstract: A topical lodoxamide composition having enhanced efficacy for treatment of ocular allergic diseases. The composition comprises the addition of polyvinyl alcohol to an aqueous solution containing lodoxamide tromethamine.

Abstract: A method of preparing solutions containing thimerosal and polyvinylpyrrolidone which results in improved stability of thimerosal is disclosed. The method involves applying a certain amount of heat to the polyvinylpyrrolidone while it is in aqueous solution and prior to its combination with thimerosal. The required thermal input to the polyvinylpyrrolidone solution is a function of four variables: solution temperature, heating time, external pressure and polyvinylpyrrolidone concentration. Advantageously this method may be employed in the manufacture of contact lens solutions.

Abstract: A method and composition for the treatment of contact lenses, and especially soft contact lenses such as silicone and hydrophilic plastic contact lenses to remove inorganic deposits. The method consists of treating a contact lens with an aqueous solution containing an effective amount of a sequestering agent, such as a polymetaphosphate, gluconic acid or salts thereof. A preferred polymetaphosphate is sodium hexametaphosphate.

Abstract: Low serum zinc concentrations in humans have been associated with multiple sclerosis in some patients, particularly those patients under 50 years of age. Increasing the concentration of serum zinc in such patients has been found to lower the number of, or decrease the severity of recurrent attacks and/or improve neurologic function in some patients.

Abstract: A method for topically treating inflammation in humans or animals by administering to the inflamed area a therapeutically effective amount of an alkyl- or aralkyl-substituted acetylsalicylic acid such as methyl-, ethyl-, allyl- or benzyl acetylsalicylate. The method may also be used to treat acne by applying a therapeutically effective amount of the acetylsalicylate ester to the affected skin in a human having skin affected by acne.

Abstract: A method of treating vascularization of the eye as a result of traumatic injury, surgery, such as, corneal transplant, or onset of diabetic retinopathy by topically treating the eye with Flurbiprofen or a pharmaceutically acceptable salt thereof.

Abstract: An ophthalmic composition comprising Prazosin or a pharmaceutically acceptable salt thereof and a topically administrable ophthalmic pharmaceutical carrier. The foregoing composition is useful in lowering intraocular pressure in the eye. Reduction of intraocular pressure is of particular importance in the treatment of glaucoma, a disease characterized by elevated intraocular pressure.

Abstract: A method of stabilizing an aqueous, peroxide containing composition and the resulting stabilized composition. Preferably, EDTA and a magnesium salt are also included in the stabilized composition.

Abstract: An ophthalmic composition comprising a compound having the structural formula ##STR1## wherein X is selected from the group consisting of CH.sub.2 --CH.sub.2, CH.sub.2 and OCH.sub.2 ; and Y is selected from the group consisting of phenyl, P-methoxy phenyl and O-methoxy phenyl and a pharmaceutically acceptable salt thereof and a topically administrable ophthalmic pharmaceutical carrier. The foregoing composition is useful in lowering intraocular pressure in the eye. Reduction of intraocular pressure is of particular importance in the treatment of glaucoma, a disease characterized by elevated intraocular pressure.