Abstract: To provide an activator of gene expression of molecular chaperone gene and applications thereof. This activator of gene expression of molecular chaperone gene contains an eggshell membrane component, for example, a powder containing eggshell membrane or a soluble eggshell membrane component. Moreover, the powder containing eggshell membrane used in the present invention may be a fine powder preferably having 6 ?m or less in the mean volume particle diameter of the fine powder containing eggshell membranes, and/or 20 ?m or less in the maximum volume particle diameter thereof, but not limited to these values.

Abstract: Providing an agent for activating a sirtuin gene and an application thereof. The agent for activating a sirtuin gene is characterized to contain an egg shell membrane ingredient, for example an egg shell membrane-containing powder or soluble egg shell membrane ingredient.

Abstract: The hepatoprotective agent contains eggshell membrane-containing fine powder, wherein the eggshell membrane-containing fine powder is eggshell membrane-containing fine powder having a volume mean particle diameter of 6 ?m or less and/or eggshell membrane-containing fine powder having a volume maximum particle diameter of 20 ?m or less. When fed with feed including eggshell membrane-containing fine powder with these values (sample C), the liver injury group (CCl4) caused a significant weight loss compared with the control group (control), but the test group ESM, the eggshell membrane-fed group (ESM) maintained the equal weight to the control group.