Patents Assigned to Altus Pharmaceuticals Inc.
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Publication number: 20100255100Abstract: This invention relates to methods for the stabilization, storage and delivery of biologically active macromolecules, such as proteins, peptides and nucleic acids. In particular, this invention relates to protein or nucleic acid crystals, formulations and compositions comprising them. Methods are provided for the crystallization of proteins and nucleic acids and for the preparation of stabilized protein or nucleic acid crystals for use in dry or slurry formulations. The present invention is further directed to encapsulating proteins, glycoproteins, enzymes, antibodies, hormones and peptide crystals or crystal formulations into compositions for biological delivery to humans and animals. According to this invention, protein crystals or crystal formulations are encapsulated within a matrix comprising a polymeric carrier to form a composition.Type: ApplicationFiled: October 30, 2009Publication date: October 7, 2010Applicant: Altus Pharmaceuticals Inc.Inventors: Alexey J. Margolin, Nazar K. Khalaf, Nancy L. St. Clair, Scott L. Rakestraw, Bhami C. Shenoy
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Patent number: 7659106Abstract: The present invention relates to a process for the biocatalyst-mediated enantioselective conversion of enantiomeric mixtures of hydrophobic esters using a biphasic solvent system. More particularly, the present invention relates to the enzyme-mediated enantioselective synthesis of anti-viral compounds, such as 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane (FTC) and its analogues, in a non-homogenous reaction system.Type: GrantFiled: December 27, 2005Date of Patent: February 9, 2010Assignees: Altus Pharmaceuticals Inc., Gilead Sciences, Inc.Inventors: Merrick R. Almond, Wang Yi Fong, Yao Yiming
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Publication number: 20090093617Abstract: This invention relates to crystals of whole antibodies and fragments thereof, and formulations and compositions comprising such crystals. More particularly, methods are provided for the crystallization of high concentrations of whole antibodies, and fragments thereof, in large batches, and for the preparation of stabilized whole antibody crystals for use alone, or in dry or slurry formulations or compositions. This invention also relates to methods for stabilization, storage and delivery of biologically active whole antibody crystals. The present invention further relates to methods using whole antibody crystals, antibody fragment crystals, or compositions or formulations comprising such crystals for biomedical applications, including biological delivery to humans and animals.Type: ApplicationFiled: September 25, 2008Publication date: April 9, 2009Applicant: ALTUS PHARMACEUTICALS INC.Inventors: Bhami Shenoy, Chandrika P. Govardhan, Mark X. Yang, Alexey L. Margolin
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Publication number: 20090081184Abstract: This invention relates to methods for maintaining the basal level or reducing the level of cholecystokinin (CCK) in blood plasma of a mammal. Additionally, the invention provides methods for treating pain in a mammal and more particularly, methods for treating abdominal pain in a mammal. The methods include administering to the mammal a non-pancreatic protease or a composition comprising a non-pancreatic protease. The methods of this invention are particularly useful for treating abdominal pain in a mammal suffering from acute or chronic pancreatitis and related conditions.Type: ApplicationFiled: October 24, 2008Publication date: March 26, 2009Applicant: Altus Pharmaceuticals Inc.Inventors: Alexey L. Margolin, Bhami C. Shenoy, Margaret McGrath
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Publication number: 20090023629Abstract: The present invention relates to compositions comprising polycation-complexed protein crystals and hyaluronic acid. Advantageously, the compositions of this invention are stable, long-acting and avoid local reactions at the injection site. Compositions according to this invention include sustained-release human growth hormone compositions. Such compositions are useful for treating a subject having a disorder associated with human growth hormone deficiency or that is ameliorated by human growth hormone therapy.Type: ApplicationFiled: December 22, 2006Publication date: January 22, 2009Applicant: ALTUS PHARMACEUTICALS INC.Inventors: Susan Yun Qu, Shubhang Mishra, Benjamin Paul Simeone, Sujit Kumar Basu
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Patent number: 7459155Abstract: This invention relates to methods for maintaining the basal level or reducing the level of cholecystokinin (CCK) in blood plasma of a mammal. Additionally, the invention provides methods for treating pain in a mammal and more particularly, methods for treating abdominal pain in a mammal. The methods include administering to the mammal a non-pancreatic protease or a composition comprising a non-pancreatic protease. The methods of this invention are particularly useful for treating abdominal pain in a mammal suffering from acute or chronic pancreatitis and related conditions.Type: GrantFiled: October 29, 2004Date of Patent: December 2, 2008Assignee: Altus Pharmaceuticals Inc.Inventors: Alexey L. Margolin, Bhami C. Shenoy, Margaret McGrath
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Publication number: 20080226623Abstract: This invention relates to methods for the stabilization, storage and delivery of biologically active macromolecules, such as proteins, peptides and nucleic acids. In particular, this invention relates to protein or nucleic acid crystals, formulations and compositions comprising them. Methods are provided for the crystallization of proteins and nucleic acids and for the preparation of stabilized protein or nucleic acid crystals for use in dry or slurry formulations. The present invention is further directed to encapsulating proteins, glycoproteins, enzymes, antibodies, hormones and peptide crystals or crystal formulations into compositions for biological delivery to humans and animals. According to this invention, protein crystals or crystal formulations are encapsulated within a matrix comprising a polymeric carrier to form a composition.Type: ApplicationFiled: February 11, 2008Publication date: September 18, 2008Applicant: Altus Pharmaceuticals Inc.Inventors: Alexey L. Margolin, Nazar K. Khalaf, Nancy L. St. Clair, Scott L. Rakestraw, Bhami C. Shenoy
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Patent number: 7351798Abstract: This invention relates to methods for the stabilization, storage and delivery of biologically active macromolecules, such as proteins, peptides and nucleic acids. In particular, this invention relates to protein or nucleic acid crystals, formulations and compositions comprising them. Methods are provided for the crystallization of proteins and nucleic acids and for the preparation of stabilized protein or nucleic acid crystals for use in dry or slurry formulations. The present invention is further directed to encapsulating proteins, glycoproteins, enzymes, antibodies, hormones and peptide crystals or crystal formulations into compositions for biological delivery to humans and animals. According to this invention, protein crystals or crystal formulations are encapsulated within a matrix comprising a polymeric carrier to form a composition.Type: GrantFiled: March 5, 2003Date of Patent: April 1, 2008Assignee: Altus Pharmaceuticals Inc.Inventors: Alexey L Margolin, Nazar K Khalaf, Nancy L St Clair, Scott L Rakestraw, Bhami C Shenoy
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Publication number: 20080038246Abstract: Oxalate decarboxylase crystals, including stabilized crystals, such as cross-linked crystals of oxalate decarboxylase, are disclosed. Methods to treat a disorder associated with elevated oxalate concentration using oxalate decarboxylase crystals are also disclosed. Additionally disclosed are methods of producing protein crystals.Type: ApplicationFiled: August 2, 2007Publication date: February 14, 2008Applicant: ALTUS PHARMACEUTICALS INC.Inventors: Bhami Shenoy, Teresa Cachero, John Shin, Lekai Zhang, Aftab Rashid, Danica Grujic, Reena Patel, Margaret McGrath
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Patent number: 7087728Abstract: The present invention relates to the field of carbohydrate crosslinked glycoprotein crystals. Advantageously, such crosslinked glycoprotein crystals display stability to harsh environmental conditions, while maintaining the structural and functional integrity of the glycoprotein backbone. According to one embodiment, this invention relates to methods for concentrating proteins that have been modified by carbohydrates and for releasing their activity at controlled rates. This invention also provides methods for producing carbohydrate crosslinked glycoprotein crystals and methods for using them in pharmaceutical formulations, vaccines, immunotherapeutics, personal care compositions, including cosmetics, veterinary pharmaceutical compositions and vaccines, foods, feeds, diagnostics, cleaning agents, including detergents and decontamination formulations.Type: GrantFiled: December 23, 2002Date of Patent: August 8, 2006Assignee: Altus Pharmaceuticals Inc.Inventors: Alexey L Margolin, Chandrika P Govardhan, Kalevi J Visuri, Sinikka S Uotila