Patents Assigned to ALZA Corporation
  • Apparatus for transdermal delivery of parathyroid hormone agents
    Patent number: 8361022
    Abstract: An apparatus and method for transdermally delivering a biologically active agent comprising a delivery system having a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, the PTH-based agent is contained in a biocompatible coating that is applied to the microprojection member.
    Type: Grant
    Filed: July 1, 2009
    Date of Patent: January 29, 2013
    Assignee: Alza Corporation
    Inventors: Mahmoud Ameri, Michel J. N. Cormier, Yuh-Fun Maa, Peter E. Daddona, Marika Kamberl
  • TRANSPARENT TRANSDERMAL NICOTINE DELIVERY DEVICES
    Publication number: 20120310187
    Abstract: A transparent transdermal delivery device for delivering nicotine which has an Opacity Index of less than 48.6%.
    Type: Application
    Filed: December 5, 2011
    Publication date: December 6, 2012
    Applicant: ALZA Corporation
    Inventor: Robert M. Gale
  • Methods and apparatus for determining formulation orientation of multi-layered pharmaceutical dosage forms
    Patent number: 8323691
    Abstract: Rapid and accurate determination of the formulation orientation of multi-layer capsule-shaped tablets with respect to different internal formulation layers proximate to the opposite narrow and rounded ends of the tablets is required. By including an appropriate color scheme in multi-layer osmotic tablets, detection of the formulation orientation is achieved by detecting the color at a spot location on a side of the tablet corresponding to one or another formulation layer or to one or another interface of two formulation layers depending on the formulation orientation of the tablet.
    Type: Grant
    Filed: March 11, 2009
    Date of Patent: December 4, 2012
    Assignee: Alza Corporation
    Inventors: Johan H. Geerke, Steven F. Stone
  • Two-part electrotransport device
    Patent number: 8301238
    Abstract: A switch operated therapeutic agent delivery device is described. The device comprises two parts, which are assembled by a user prior to use. A first part contains a power supply and circuitry for the device; and a second part comprises electrodes and reservoirs containing the therapeutic agent to be delivered. The action of combining the two parts of the device causes the two parts to be irreversibly coupled together, completes an electrical connection between the two parts, and closes one or more switches, thereby connecting a power source, such as a battery, into the device's circuitry, thereby powering the device on so that it is ready for use. The device can then be attached to a patient, who can operate the device by pressing a button in a proper sequence.
    Type: Grant
    Filed: September 30, 2011
    Date of Patent: October 30, 2012
    Assignees: Incline Therapeutics, Inc., Alza Corporation
    Inventors: Zita S. Netzel, John Lemke, David Seward, Brian W. Read, Bradley E. White, Corinna X. Chen, Paul Hayter
  • Drug coating providing high drug loading
    Patent number: 8246986
    Abstract: Aqueous drug coatings including at least one insoluble drug, wherein the insoluble drug accounts for about 85 wt % to about 97 wt % of the drug coatings are described. Such drug coatings may include only one insoluble drug, two or more insoluble drugs, or one or more insoluble drugs in combination with one or more soluble drugs.
    Type: Grant
    Filed: September 23, 2004
    Date of Patent: August 21, 2012
    Assignee: Alza Corporation
    Inventors: Evangeline Cruz, Gregory Ruhlmann, Brenda Pollock, Sherry Li, Carmelita Garcia, Alfredo M. Wong, Ryan Bronz, Tracy Fink, David Edgren
  • Drug coating providing high drug loading and methods for providing the same
    Patent number: 8226979
    Abstract: The present invention is directed to aqueous drug coatings that include at least one insoluble drug, wherein the drug accounts for about 85 wt % to about 97 wt % of the drug coatings. A drug coating according to the present invention may include only one insoluble drug, two or more insoluble drugs, or one or more insoluble drugs in combination with one or more soluble drugs. The present invention also includes drug coating formulations suitable for providing drug coatings according to the present invention and dosage forms that include a drug coating according to the present invention.
    Type: Grant
    Filed: April 11, 2011
    Date of Patent: July 24, 2012
    Assignee: Alza Corporation
    Inventors: Evangeline Cruz, Gregory Ruhlmann, Brenda Pollock, Sherry Li, Carmelita Garcia, Alfredo M. Wong, Ryan Bronz, Tracy Fink, David Edgren
  • Electrotransport device having a reservoir housing having a flexible conductive element
    Patent number: 8224435
    Abstract: This invention relates to an electrotransport device, which incorporates a flexible conductive element within the reservoir housing of the device, which permits electrical communication from within the housing to outside of the housing without the use of opening, which require various methods of sealing the opening against leaks and moisture.
    Type: Grant
    Filed: March 30, 2004
    Date of Patent: July 17, 2012
    Assignee: Alza Corporation
    Inventor: J. Richard Gyory
  • Device for transdermal electrotransport delivery of fentanyl and sufentanil
    Patent number: 8200327
    Abstract: The invention provides an improved electrotransport drug delivery system for analgesic drugs, namely fentanyl and sufentanil. The fentanyl/sufentanil is provided as a water soluble salt (e.g., fentanyl hydrochloride), preferably in a hydrogel formulation, for use in an electrotransport device. In accordance with the present invention, a transdermal electrotransport delivered dose of fentanyl/sufentanil is provided which is sufficient to induce analgesia in (e.g., adult) human patients suffering from moderate-to-severe pain associated with major surgical procedures.
    Type: Grant
    Filed: July 12, 2006
    Date of Patent: June 12, 2012
    Assignee: ALZA Corporation
    Inventors: Mary Southam, Keith J. Bernstein, Henk Noorduin
  • Methods and devices for providing prolonged drug therapy
    Patent number: 8163798
    Abstract: Methods and devices for maintaining a desired therapeutic drug effect over a prolonged therapy period are provided. In particular, oral dosage forms that release drug within the gastrointestinal tract at an ascending release rate over an extended time period are provided. The dosage forms may additionally comprise an immediate-release dose of drug.
    Type: Grant
    Filed: August 12, 2003
    Date of Patent: April 24, 2012
    Assignee: Alza Corporation
    Inventors: Suneel K. Gupta, Diane R. Guinta, Carol A. Christopher, Samuel R. Saks, Lawrence G. Hamel
  • ANTIDEPRESSANT DOSAGE FORM
    Publication number: 20120070496
    Abstract: A dosage form having sustained-release or controlled-release properties for delivering 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]-cyclohexanol from the dosage form over an extended period of time in a therapeutically responsive dose to produce antidepressant therapy.
    Type: Application
    Filed: November 23, 2011
    Publication date: March 22, 2012
    Applicant: Alza Corporation
    Inventors: David Emil Edgren, Gurdish Kaur Bhatti, Zahedeh Hatamkhani, Patrick S.-L. Wong
  • Static diffusion cell for diffusion sampling systems
    Patent number: 8133721
    Abstract: A new design for a static diffusion cell for use in a diffusion sampling apparatus to be used in conjunction with automated or manual sampling is disclosed. The diffusion cell of present invention provides to an improved and efficient diffusion assay system.
    Type: Grant
    Filed: November 21, 2008
    Date of Patent: March 13, 2012
    Assignee: Alza Corporation
    Inventors: Hua Yang, Delphine Caroline Imbert
  • Antidepressant dosage form
    Patent number: 8084059
    Abstract: The invention pertains to a dosage form 10 and to administering an antidepressant medicament 16 for an extended period of time in a rate-known dose.
    Type: Grant
    Filed: September 15, 2006
    Date of Patent: December 27, 2011
    Assignee: ALZA Corporation
    Inventors: David Emil Edgren, Gurdish Kaur Bhatti, Zahedeh Hatamkhani, Patrick S. L. Wong
  • Transparent transdermal nicotine delivery devices
    Patent number: 8075911
    Abstract: A transparent transdermal delivery device for delivering nicotine which has an Opacity Index of less than 48.6%.
    Type: Grant
    Filed: August 20, 2007
    Date of Patent: December 13, 2011
    Assignee: Alza Corporation
    Inventor: Robert M. Gale
  • Liposomes containing an entrapped compound in supersaturated solution
    Patent number: 8062662
    Abstract: A liposome composition having a compound entrapped in a supersaturated solution and method for preparing such a composition are described.
    Type: Grant
    Filed: March 16, 2006
    Date of Patent: November 22, 2011
    Assignees: Alza Corporation, Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Danilo D. Lasic, Robert M. Abra, Yechezkel Barenholz, Tal Peleg-Shulman
  • EXTENDED RELEASE DOSAGE FORM
    Publication number: 20110229533
    Abstract: A membrane system comprising an interior wall, a fluid-permeable exterior wall surrounding the interior wall and an internal compartment defined by the membrane system, wherein fluid permeability of the interior wall is responsive to osmolarity of an osmotic core within the internal compartment are disclosed. A controlled release dosage form comprising the membrane system and a process for delivering an osmotically active formulation from an osmotic pump over an extended period of time are also disclosed.
    Type: Application
    Filed: May 31, 2011
    Publication date: September 22, 2011
    Applicant: ALZA Corporation
    Inventors: David E. Edgren, Patrick S.-L. Wong, Gurdish K. Bhatti, Shu Li, Robert R. Skluzacek
  • Microprojection array having a beneficial agent containing coating
    Patent number: 7963935
    Abstract: The device including a plurality of stratum corneum-piercing microprojections, and a solid coating disposed upon the microprojections, wherein the solid coating includes at least one beneficial agent and a biocompatible carrier is provided. The device is applied to the skin of a living animal (e.g., a human), causing the microprojections to pierce the stratum corneum and deliver an effective dose of the agent to the animal.
    Type: Grant
    Filed: April 20, 2002
    Date of Patent: June 21, 2011
    Assignee: Alza Corporation
    Inventors: Michel J. N. Cormier, Wendy A. Young, Juanita A. Johnson, Peter E. Daddona
  • Electrotransport device having an integrally molded reservoir housing
    Patent number: 7844326
    Abstract: This invention relates to an electrotransport device, which incorporates a conductive element within the reservoir housing of the device, which permits electrical communication from within the housing to outside of the housing without the use of opening, which require various methods of sealing the openings against leaks and moisture.
    Type: Grant
    Filed: December 20, 2002
    Date of Patent: November 30, 2010
    Assignee: Alza Corporation
    Inventors: Wanda Faye Dent, J. Richard Gyory, Michael Joseph Grace
  • Transdermal electrotransport delivery device including an antimicrobial compatible reservoir composition
    Patent number: 7801599
    Abstract: A transdermal electrotransport drug delivery device having an anode, a cathode and a source of electrical power electrically connected to the anode and the cathode. At least one of the anode and the cathode includes an electrode and a reservoir comprised of a housing composed of a polymeric material and an aqueous medium in contact with the housing. The aqueous medium includes (i) a drug or an electrolyte salt or a mixture thereof, (ii) propylene glycol, and (iii) an antimicrobial agent in an amount sufficient to inhibit microbial growth in the aqueous medium. The propylene glycol prevents the antimicrobial agent from being adsorbed by other materials used in the construction of the delivery device. A process for preparing a transdermal electrotransport drug delivery device is also provided.
    Type: Grant
    Filed: November 3, 2006
    Date of Patent: September 21, 2010
    Assignee: Alza Corporation
    Inventors: Wendy A. Young, Michel J. Cormier
  • Apparatus and method for piercing skin with microprotrusions
    Patent number: 7798987
    Abstract: A method and device are described for applying a microprotrusion member (44) including a plurality of microprotrusions (90) to the stratum corneum with impact. The method and device are used to improve transport of an agent across the skin for agent delivery or sampling. The applicator (10, 60, 80) causes the microprotrusion member (44) to impact the stratum corneum with a certain amount of impact determined to effectively pierce the skin with the microprotrusions (90). The preferred applicator (10, 60, 80) impacts the stratum corneum with the microprotrusion member (44) with an impact of at least 0.05 joules per cm2 of the microprotrusion member (44) in 10 msec or less.
    Type: Grant
    Filed: March 28, 2005
    Date of Patent: September 21, 2010
    Assignee: Alza Corporation
    Inventors: Joseph C. Trautman, Richard L. Keenan, Ahmad P. Samiee, WeiQi Lin, Michel J. N. Cormier, James A. Matriano, Peter E. Daddona
  • Formulations for coated microprojections containing non-volatile counterions
    Publication number: 20100221305
    Abstract: The invention provides for a formulation for coating one or more microprojections which reduces or minimizes the loss of counterions from the coating in order to achieve a pH-stabilized formulation.
    Type: Application
    Filed: August 24, 2009
    Publication date: September 2, 2010
    Applicant: Alza Corporation
    Inventors: Mahmoud Armeri, Wei-Qi Lin, Michel J.N. Cormier, Yuh-Fun Maa