Abstract: In accordance with exemplary embodiments, the present disclosure comprises a device, system and methods for water and/or nutrient-efficient hydroponic gardening. In accordance with exemplary embodiments, the device comprises a grow cup which allows plants to develop and grow roots in one or more of a hydrozone, an aerozone, and a biozone. A system in accordance with exemplary embodiments of the present disclosure comprises a grow cup within a tray. Exemplary methods of enhanced hydroponic gardening comprise providing a grow cup, adding one or more grow media to each of a hydrozone, an aerozone, and a biozone within the grow cup, submersing the hydrozone in a highly oxygenated water and/or nutrient solution, and planting a plant in the biozone.