Patents Assigned to AnaSpec Incorporated
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Publication number: 20150330973Abstract: Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3?-position, their bioconjugates and their uses are described. 1,3?-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1?-crosslinked or non-crosslinked dyes. The invention includes derivative compounds having one or more benzo nitrogens.Type: ApplicationFiled: April 6, 2015Publication date: November 19, 2015Applicant: AnaSpec IncorporatedInventors: Zhenjun Diwu, Jianheng Zheng, Yi Tang, Xiang Guobing
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Patent number: 9006469Abstract: The quenching compounds of the invention are weakly luminescent cyanines that are substituted by one or more heteroaromatic quenching moieties. The quenching compounds of the invention exhibit little or no observable luminescence and efficiently quench a broad spectrum of luminescent compounds. The chemically reactive quenching compounds possess utility for labeling a wide variety of substances, including biomolecules. These labeled substances are highly useful for a variety of energy-transfer assays and applications.Type: GrantFiled: April 17, 2013Date of Patent: April 14, 2015Assignee: AnaSpec IncorporatedInventors: Zhenjun Diwu, Jianheng Zhang, Yi Tang
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Patent number: 8999690Abstract: Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3?-position, their bioconjugates and their uses are described. 1,3?-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1?-crosslinked or non-crosslinked dyes. The invention includes derivative compounds having one or more benzo nitrogens.Type: GrantFiled: January 27, 2012Date of Patent: April 7, 2015Assignee: AnaSpec IncorporatedInventors: Zhenjun Diwu, Jianheng Zhang, Yi Tang, Xiang Guobing
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Patent number: 8921543Abstract: Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3?-position, their bioconjugates and their uses are described. 1,3?-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1?-crosslinked or non-crosslinked dyes. The invention includes derivative compounds having one or more benzo nitrogens.Type: GrantFiled: January 9, 2012Date of Patent: December 30, 2014Assignee: AnaSpec IncorporatedInventors: Zhenjun Diwu, Jianheng Zhang, Yi Tang, Xiang Guobing
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Publication number: 20140031524Abstract: The quenching compounds of the invention are weakly luminescent cyanines that are substituted by one or more heteroaromatic quenching moieties. The quenching compounds of the invention exhibit little or no observable luminescence and efficiently quench a broad spectrum of luminescent compounds. The chemically reactive quenching compounds possess utility for labeling a wide variety of substances, including biomolecules. These labeled substances are highly useful for a variety of energy-transfer assays and applications.Type: ApplicationFiled: April 17, 2013Publication date: January 30, 2014Applicant: AnaSpec IncorporatedInventor: AnaSpec Incorporated
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Publication number: 20130210113Abstract: Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3?-position, their bioconjugates and their uses are described. 1,3?-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1?-crosslinked or non-crosslinked dyes. The invention includes derivative compounds having one or more benzo nitrogens.Type: ApplicationFiled: December 18, 2012Publication date: August 15, 2013Applicant: AnaSpec IncorporatedInventor: AnaSpec Incorporated
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Patent number: 8426618Abstract: The quenching compounds of the invention are weakly luminescent cyanines that are substituted by one or more heteroaromatic quenching moieties. The quenching compounds of the invention exhibit little or no observable luminescence and efficiently quench a broad spectrum of luminescent compounds. The chemically reactive quenching compounds possess utility for labeling a wide variety of substances, including biomolecules. These labeled substances are highly useful for a variety of energy-transfer assays and applications.Type: GrantFiled: January 9, 2012Date of Patent: April 23, 2013Assignee: AnaSpec IncorporatedInventors: Zhenjun Diwu, Jianheng Zhang, Yi Tang
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Patent number: 8420402Abstract: The present invention is generally directed to thiol quantitation assays, methods of performing the assays, and compounds used in the assays. It is more specifically directed to assays that include one or more disulfides and related molecules and methods. The disulfides contain a FRET pair.Type: GrantFiled: January 27, 2012Date of Patent: April 16, 2013Assignee: AnaSpec IncorporatedInventors: Jianjun He, Anita Hong, Qingheng Wang, Raman Khosrow Afshar, Ming Zhu, Vera Rakhmanova
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Patent number: 8329390Abstract: The present invention relates generally to the detection and measurement of transmembrane potentials using an N,N,N?-trialkyl thiobarbituric acid-derived polymethine oxonol (shown below). In particular, the present invention is directed to compositions and optical methods for determining transmembrane potentials across the plasma membrane of biological cells using a slightly hydrophobic N,N,N?-trialkyl thiobarbituric acid-derived polymethine oxonols. The method comprises a slightly hydrophobic N,N,N?-trialkyl thiobarbituric acid-derived polymethine oxonol anion capable of redistributing from a first face of the membrane to a second face of the membrane in response to changes in the potential of the membrane. In one aspect the method is used to identify compounds which modulate membrane potentials in biological membranes.Type: GrantFiled: August 25, 2005Date of Patent: December 11, 2012Assignee: AnaSpec IncorporatedInventors: Zhenjun Diwu, Jianjun He, Yi Tang
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Patent number: 8304560Abstract: Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3?-position, their bioconjugates and their uses are described. 1,3?-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1?-crosslinked or non-crosslinked dyes. The invention includes derivative compounds having one or more benzo nitrogens.Type: GrantFiled: July 26, 2011Date of Patent: November 6, 2012Assignee: AnaSpec IncorporatedInventors: Zhenjun Diwu, Jianheng Zhang, Yi Tang, Xiang Guobing
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Publication number: 20120258514Abstract: Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3?-position, their bioconjugates and their uses are described. 1,3?-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1?-crosslinked or non-crosslinked dyes. The invention includes derivative compounds having one or more benzo nitrogens.Type: ApplicationFiled: January 27, 2012Publication date: October 11, 2012Applicant: AnaSpec IncorporatedInventors: Zhenjun Diwu, Jianheng Zhang, Yi Tang, Xiang Guobing
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Publication number: 20120238745Abstract: Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3?-position, their bioconjugates and their uses are described. 1,3?-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1?-crosslinked or non-crosslinked dyes. The invention includes derivative compounds having one or more benzo nitrogens.Type: ApplicationFiled: January 9, 2012Publication date: September 20, 2012Applicant: AnaSpec IncorporatedInventors: Zhenjun Diwu, Jianheng Zhang, Yi Tang, Xiang Guobing
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Patent number: 8257926Abstract: Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3?-position, their bioconjugates and their uses are described. 1,3?-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1?-crosslinked or non-crosslinked dyes. The invention includes derivative compounds having one or more benzo nitrogens.Type: GrantFiled: July 25, 2011Date of Patent: September 4, 2012Assignee: AnaSpec IncorporatedInventors: Zhenjun Diwu, Jianheng Zhang, Yi Tang, Xiang Guobing
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Patent number: 8258292Abstract: Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3?-position, their bioconjugates and their uses are described. 1,3?-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1?-crosslinked or non-crosslinked dyes. The invention includes derivative compounds having one or more benzo nitrogens.Type: GrantFiled: October 6, 2008Date of Patent: September 4, 2012Assignee: AnaSpec IncorporatedInventors: Zhenjun Diwu, Jianheng Zhang, Yi Tang, Xiang Guobing
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Publication number: 20120130057Abstract: The present invention is generally directed to thiol quantitation assays, methods of performing the assays, and compounds used in the assays. It is more specifically directed to assays that include one or more disulfides and related molecules and methods. The disulfides contain a FRET pair.Type: ApplicationFiled: January 27, 2012Publication date: May 24, 2012Applicant: AnaSpec IncorporatedInventors: Jianjun He, Anita Hong, Qingheng Wang, Raman Khosrow Afshar, Ming Zhu, Vera Rakhmanova
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Publication number: 20120123109Abstract: The quenching compounds of the invention are weakly luminescent cyanines that are substituted by one or more heteroaromatic quenching moieties. The quenching compounds of the invention exhibit little or no observable luminescence and efficiently quench a broad spectrum of luminescent compounds. The chemically reactive quenching compounds possess utility for labeling a wide variety of substances, including biomolecules. These labeled substances are highly useful for a variety of energy-transfer assays and applications.Type: ApplicationFiled: January 9, 2012Publication date: May 17, 2012Applicant: AnaSpec IncorporatedInventors: Zhenjun Diwu, Jianheng Zhang, Yi Tang
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Patent number: 8129193Abstract: The present invention is generally directed to thiol quantitation assays, methods of performing the assays, and compounds used in the assays. It is more specifically directed to assays that include one or more disulfides and related molecules and methods. The disulfides contain a FRET pair.Type: GrantFiled: July 28, 2010Date of Patent: March 6, 2012Assignee: AnaSpec IncorporatedInventors: Jianjun He, Anita Hong, Qingzheng Wang, Raman Khosrow Afshar, Ming Zhu, Vera Rakhmanova
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Patent number: 8105829Abstract: Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3?-position, their bioconjugates and their uses are described. 1,3?-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1?-crosslinked or non-crosslinked dyes. The invention includes derivative compounds having one or more benzo nitrogens.Type: GrantFiled: October 21, 2010Date of Patent: January 31, 2012Assignee: AnaSpec IncorporatedInventors: Zhenjun Diwu, Jianheng Zhang, Yi Tang, Xiang Guobing
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Patent number: 8093404Abstract: Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3?-position, their bioconjugates and their uses are described. 1,3?-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1?-crosslinked or non-crosslinked dyes. The invention includes derivative compounds having one or more benzo nitrogens.Type: GrantFiled: August 20, 2009Date of Patent: January 10, 2012Assignee: AnaSpec IncorporatedInventors: Zhenjun Diwu, Jianheng Zhang, Yi Tang, Xiang Guobing
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Patent number: 8093411Abstract: The quenching compounds of the invention are weakly luminescent cyanines that are substituted by one or more heteroaromatic quenching moieties. The quenching compounds of the invention exhibit little or no observable luminescence and efficiently quench a broad spectrum of luminescent compounds. The chemically reactive quenching compounds possess utility for labeling a wide variety of substances, including biomolecules. These labeled substances are highly useful for a variety of energy-transfer assays and applications.Type: GrantFiled: August 30, 2010Date of Patent: January 10, 2012Assignee: AnaSpec IncorporatedInventors: Zhenjun Diwu, Jianheng Zhang, Yi Tang