Abstract: The present invention provides a method of protecting the heart from damage, by administering to a patient at risk of such damage, a pharmaceutically effective amount of a composition which inhibits the interaction of RSK3 and mAKAP?, or the expression or activity of one or both of those molecules. This composition may be in the form of a peptide that specifically inhibits mAKAP? binding to RSK3 or in the form of an siRNA construct which inhibits the expression of RSK3.
Type:
Application
Filed:
January 21, 2022
Publication date:
May 12, 2022
Applicant:
Anchored RSK3 Inhibitors, LLC
Inventors:
Michael S. KAPILOFF, Jinliang LI, Michael KRITZER
Abstract: The present invention provides a method of protecting the heart from damage, by administering to a patient at risk of such damage, a pharmaceutically effective amount of a composition which inhibits the interaction of RSK3 and mAKAP?, or the expression or activity of one or both of those molecules. This composition may be in the form of a peptide that specifically inhibits mAKAP? binding to RSK3 or in the form of an siRNA construct which inhibits the expression of RSK3.
Type:
Grant
Filed:
April 1, 2020
Date of Patent:
January 25, 2022
Assignee:
ANCHORED RSK3 INHIBITORS, LLC
Inventors:
Michael S. Kapiloff, Jinliang Li, Michael Kritzer
Abstract: The present invention provides a method of protecting the heart from damage, by administering to a patient at risk of such damage, a pharmaceutically effective amount of a composition which inhibits the interaction of RSK3 and mAKAP?, or the expression or activity of one or both of those molecules. This composition may be in the form of a peptide that specifically inhibits mAKAP? binding to RSK3 or in the form of an siRNA construct which inhibits the expression of RSK3.
Type:
Application
Filed:
April 1, 2020
Publication date:
September 17, 2020
Applicant:
Anchored RSK3 Inhibitors, LLC
Inventors:
Michael S. KAPILOFF, Jinliang LI, Michael KRITZER
Abstract: The present invention provides a method of protecting the heart from damage, by administering to a patient at risk of such damage, a pharmaceutically effective amount of a composition which inhibits the interaction of RSK3 and mAKAP?, or the expression or activity of one or both of those molecules. This composition may be in the form of a peptide that specifically inhibits mAKAP? binding to RSK3 or in the form of an siRNA construct which inhibits the expression of RSK3.
Type:
Grant
Filed:
April 5, 2018
Date of Patent:
April 14, 2020
Assignee:
Anchored RSK3 Inhibitors, LLC
Inventors:
Michael S. Kapiloff, Jinliang Li, Michael Kritzer
Abstract: The present invention provides a method of protecting the heart from damage, by administering to a patient at risk of such damage, a pharmaceutically effective amount of a composition which inhibits the interaction of RSK3 and mAKAP?, or the expression or activity of one or both of those molecules. This composition may be in the form of a peptide that specifically inhibits mAKAP? binding to RSK3 or in the form of an siRNA construct which inhibits the expression of RSK3.
Type:
Application
Filed:
April 5, 2018
Publication date:
October 18, 2018
Applicant:
Anchored RSK3 Inhibitors, LLC
Inventors:
Michael S. KAPILOFF, Jinliang LI, Michael KRITZER, Catherine PASSARIELLO, Kimberly DODGE-KAFKA
Abstract: The present invention provides a method of protecting the heart from damage, by administering to a patient at risk of such damage, a pharmaceutically effective amount of a composition which inhibits the interaction of RSK3 and mAKAP?, or the expression or activity of one or both of those molecules. This composition may be in the form of a peptide that specifically inhibits mAKAP? binding to RSK3 or in the form of an siRNA construct which inhibits the expression of RSK3.
Type:
Grant
Filed:
August 7, 2015
Date of Patent:
April 10, 2018
Assignee:
ANCHORED RSK3 INHIBITORS, LLC
Inventors:
Michael S Kapiloff, Jinliang Li, Michael Kritzer, Catherine Passariello, Kimberly Dodge-Kafka
Abstract: The present invention provides a method of protecting the heart from damage, by administering to a patient at risk of such damage, a pharmaceutically effective amount of a composition which inhibits the interaction of RSK3 and mAKAP?, or the expression or activity of one or both of those molecules. This composition may be in the form of a peptide that specifically inhibits mAKAP? binding to RSK3 or in the form of an siRNA construct which inhibits the expression of RSK3.
Type:
Application
Filed:
August 7, 2015
Publication date:
February 11, 2016
Applicant:
Anchored RSK3 Inhibitors, LLC
Inventors:
Michael S. KAPILOFF, Jinliang Li, Michael Kritzer, Catherine Passariello, Kimberly Dodge-Kafka
Abstract: The present invention provides a method of protecting the heart from damage, by administering to a patient at risk of such damage, a pharmaceutically effective amount of a composition which inhibits the interaction of RSK3 and mAKAP?, or the expression or activity of one or both of those molecules. This composition may be in the form of a peptide that specifically inhibits mAKAP? binding to RSK3 or in the form of an siRNA construct which inhibits the expression of RSK3.
Type:
Grant
Filed:
March 14, 2014
Date of Patent:
September 15, 2015
Assignee:
Anchored RSK3 Inhibitors, LLC
Inventors:
Michael S Kapiloff, Jinliang Li, Michael Kritzer, Catherine Passariello, Kimberly Dodge-Kafka
Abstract: The present invention provides a method of protecting the heart from damage, by administering to a patient at risk of such damage, a pharmaceutically effective amount of a composition which inhibits the interaction of RSK3 and mAKAP?, or the expression or activity of one or both of those molecules. This composition may be in the form of a peptide that specifically inhibits mAKAP? binding to RSK3 or in the form of an siRNA construct which inhibits the expression of RSK3.
Type:
Application
Filed:
March 14, 2014
Publication date:
September 25, 2014
Applicant:
ANCHORED RSK3 INHIBITORS, LLC
Inventors:
Michael S. KAPILOFF, Jinliang LI, Michael KRITZER, Catherine PASSARIELLO, Kimberly DODGE-KAFKA