Abstract: A method for enhancing angiogenesis and/or blood vascular perfusion in mammals by administering a pharmacologically effective amount of specific angiogenically active non-ionic, anionic, cationic and zwitterionic amphiphilic compounds. An angiogenically effective amount of the angiogenically active compound digitonin is in the range of at least 1.25 microgram to at least 200 microgram of digitonin. The range including enhancement of vascular perfusion is up to 50 mg of digitonin.
Type:
Grant
Filed:
June 16, 1987
Date of Patent:
May 1, 1990
Assignees:
Trustees of Boston University, Angio-Medical Corp.
Inventors:
Nicholas Catsimpoolas, Ann L. Griffith, Robert S. Sinn