Abstract: A process and processing system are disclosed that provide for the processing of many forms of waste, such as medical waste, food waste disposable diapers or the like, that both reduces the volume of waste solids and neutralizes the biological activity of such waste, thereby facilitating the disposal of potentially unhealthy or hazardous materials. The process and system also provides for the removal of coating from the surfaces of plastic waste material or for the dissolution of water soluble polymeric or fibrous waste material. Biological neutralization or, alternatively, coating removal or dissolution of water soluble waste, is accomplished by chopping the waste material and mixing it with a circulating stream of fluid such as water that is heated to a temperature which effects disinfection or sterilization or, alternatively coating removal or waste dissolution, in accordance with the needs of the user.