Abstract: A method of embolizing an area of treatment includes providing a composition that includes a radiopaque, non-biodegradable, water-insoluble iodinated benzyl ether of poly(vinyl alcohol) consisting of a poly(vinyl alcohol) (PVA) having covalently grafted thereon iodinated benzyl groups comprising from 1 to 4 iodine atoms per benzyl group as the only substituents wherein a grafted repeating unit has formula (I) wherein n is from 1 to 4: and introducing the composition into the area of treatment.
Type:
Grant
Filed:
July 8, 2015
Date of Patent:
September 6, 2016
Assignees:
ANTIA THERAPEUTICS S.A., UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Inventors:
Yves Chevalier, Géraldine Agusti, Coralie Nyffenegger, Eric Doelker, Olivier Jordan, Gert Andersen
Abstract: A method of embolizing an area of treatment includes providing a composition that includes a radiopaque, non-biodegradable, water-insoluble iodinated benzyl ether of poly(vinyl alcohol) consisting of a poly(vinyl alcohol) (PVA) having covalently grafted thereon iodinated benzyl groups comprising from 1 to 4 iodine atoms per benzyl group as the only substituents wherein a grafted repeating unit has formula (I) wherein n is from 1 to 4: and introducing the composition into the area of treatment.
Type:
Application
Filed:
July 8, 2015
Publication date:
November 26, 2015
Applicants:
ANTIA THERAPEUTICS S.A., UNIVERSITÈ CLAUDE BERNARD LYON 1 (UCBL), Centre National de la Recherche Scientifique (CNRS)
Inventors:
Yves Chevalier, Géraldine Agusti, Coralie Nyffenegger, Eric Doelker, Olivier Jordan, Gert Andersen
Abstract: The invention concerns a radiopaque, non-biodegradable, water-insoluble iodinated benzyl ether of poly(vinyl alcohol) consisting of a PVA having covalently grafted thereon iodinated benzyl groups comprising 1-4 iodine atoms per benzyl group, a process for preparing the same comprising reacting a 0-100% hydrolyzed PVA with a iodinated benzyl derivative comprising 1-4 iodine atoms per benzyl group in a polar aprotic solvent in the presence of a base in anhydrous conditions. Said iodo-benzylether-PVA is particularly useful as embolic agent in an injectable embolizing composition. The invention also concerns an injectable embolizing composition comprising said iodo-benzylether-PVA and capable of forming a cohesive mass upon contact with a body fluid by precipitation of the iodo-benzylether-PVA. Said injectable embolizing composition is particularly useful for forming in-situ a cohesive mass in a blood vessel or into a tumor.
Type:
Grant
Filed:
March 9, 2011
Date of Patent:
August 25, 2015
Assignees:
ANTIA THERAPEUTICS S.A., UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Inventors:
Yves Chevalier, Géraldine Agusti, Coralie Nyffenegger, Eric Doelker, Olivier Jordan, Gert Andersen