Patents Assigned to Apeiron Biologics AG
  • Method for increasing immunoreactivity
    Patent number: 8809288
    Abstract: The invention relates to an in vitro or ex vivo method for increasing the immunoreactivity of cells of the immune system, which were contacted with an antigen, said method comprising the reduction or inhibition of the Cbl-b function of said cells, thereby increasing the immunoreactivity of the cells towards the antigen.
    Type: Grant
    Filed: December 10, 2008
    Date of Patent: August 19, 2014
    Assignees: Medizinische Universitat Innsbruck, Apeiron Biologics AG
    Inventors: Gottfried Baier, Hans Loibner, Manfred Schuster, Gunther Lametschwandtner, Dominik Wolf
  • ACE2 activation for treatment of heart, lung and kidney disease and hypertension
    Patent number: 8802084
    Abstract: ACE2 activating compounds for prevention and treatment of cardiovascular disease, kidney disease, lung disease and hypertension are disclosed. Also disclosed are methods of diagnosing cardiovascular disease, kidney disease, lung disease and hypertension by measuring ACE2 expression or nucleotide polymorphism analysis.
    Type: Grant
    Filed: May 31, 2012
    Date of Patent: August 12, 2014
    Assignee: Apeiron Biologics AG
    Inventors: Joseph Penninger, Michael A. Crackower
  • Method for Treating a GD2 Positive Cancer
    Publication number: 20140170155
    Abstract: Preparations and methods for treating a GD2 positive cancer by administering a preparation comprising an anti-GD2 antibody to a patient, wherein the patient is not concomitantly treated with Interleukin-2 (IL-2), and wherein one or more treatment periods with the antibody may be preceded, accompanied, and/or followed by one or more treatment periods with a retinoid.
    Type: Application
    Filed: February 18, 2014
    Publication date: June 19, 2014
    Applicant: APEIRON BIOLOGICS AG
    Inventors: Hans Loibner, Oliver Mutschlechner, Ruth Ladenstein, Isabel Klier
  • ACE2 POLYPEPTIDE
    Publication number: 20140099297
    Abstract: The present invention relates to recombinant ACE2 polypeptide, where the ACE2 polypeptide is present as a dimer.
    Type: Application
    Filed: September 13, 2013
    Publication date: April 10, 2014
    Applicant: Apeiron Biologics AG
    Inventors: Manfred Schuster, Hans Loibner, Evelyne Janzek-Hawlat, Bernhard Peball, Stefan Stranner, Bettina Wagner, Robert Weik
  • SIRNA AGAINST CBL-B AND OPTIONALLY IL-2 AND IL-12 FOR USE IN THE TREATMENT OF CANCER
    Publication number: 20140010781
    Abstract: The invention relates to a method for the immune activation of NK cells by the reduction or inhibition of the Cbl-b function in said cells. This stimulates the congenital immune system and thus permits the therapy of appropriate diseases.
    Type: Application
    Filed: December 27, 2011
    Publication date: January 9, 2014
    Applicant: APEIRON BIOLOGICS AG
    Inventors: Günther Lametschwandtner, Hans Loibner, Manfred Schuster, Isabella Haslinger, Sandra Seidl
  • Recombinant ACE2 polypeptide dimer
    Patent number: 8586319
    Abstract: The present invention relates to recombinant ACE2 polypeptide, where the ACE2 polypeptide is present as a dimer. The dimer is formed specifically from glycosylated monomers and is used for producing pharmaceutical products with an extended half-life.
    Type: Grant
    Filed: June 12, 2008
    Date of Patent: November 19, 2013
    Assignee: Apeiron Biologics AG
    Inventors: Manfred Schuster, Hans Loibner, Evelyne Janzek-Hawlat, Bernhard Peball, Stefan Stranner, Bettina Wagner, Robert Weik
  • ACE2 activation for treatment of heart, lung and kidney disease and hypertension
    Patent number: 8211426
    Abstract: ACE2 activating compounds for prevention and treatment of cardiovascular disease, kidney disease, lung disease and hypertension are disclosed. Also disclosed are methods of diagnosing cardiovascular disease, kidney disease, lung disease and hypertension by measuring ACE2 expression or nucleotide polymorphism analysis.
    Type: Grant
    Filed: July 6, 2010
    Date of Patent: July 3, 2012
    Assignee: Apeiron Biologics AG
    Inventors: Joseph M. Penninger, Michael A. Crackower
  • Method for Determining the Cbl-b Expression
    Publication number: 20120040864
    Abstract: The present invention relates to methods of determining intracellular Cbl-b protein in cells of a sample, comprising introducing an antibody, which binds Cbl-b intracellularly, into a cell, allowing contracting of the antibody and Cbl-b protein potentially present in the cell, detecting binding events between the antibody and Cbl-b, quantifying the detected binding events, whereby the content of Cbl-b protein is determined.
    Type: Application
    Filed: April 14, 2010
    Publication date: February 16, 2012
    Applicants: MEDIZINISCHE UNIVERSITAET INNSBRUCK, APEIRON BIOLOGICS AG
    Inventors: Hans Loibner, Gottfried Baier, Gunther Lametschwandtner, Manfred Schuster, Thomas Gruber, Dominik Wolf
  • ACE2 Polypeptide
    Publication number: 20100310546
    Abstract: The present invention relates to recombinant ACE2 polypeptide, where the ACE2 polypeptide is present as a dimer. The dimer is formed specifically from glycosylated monomers and is used for producing pharmaceutical products with an extended half-life.
    Type: Application
    Filed: June 12, 2008
    Publication date: December 9, 2010
    Applicant: APEIRON BIOLOGICS AG
    Inventors: Manfred Schuster, Hans Loibner, Evelyne Janzek-Hawlat, Bernhard Peball, Stefan Stranner, Bettina Wagner, Robert Weik
  • Method for Increasing Immunoreactivity
    Publication number: 20100260808
    Abstract: The invention relates to an in vitro or ex vivo method for increasing the immunoreactivity of cells of the immune system, which were contacted with an antigen, said method comprising the reduction or inhibition of the Cbl-b function of said cells, thereby increasing the immunoreactivity of the cells towards the antigen.
    Type: Application
    Filed: December 10, 2008
    Publication date: October 14, 2010
    Applicants: MEDIZINISCHE UNIVERSITAT INNSBRUCK, APEIRON BIOLOGICS AG
    Inventors: Gottfried Baier, Hans Loibner, Manfred Schuster, Gunther Lametschwandtner, Dominik Wolf