Abstract: The present invention relates to a method for detecting a target biomolecule in a sample comprising a plurality of biomolecules, whereby the target biomolecule is provided with a tag, said tag comprising a catalytic active moiety which catalyses a reaction yielding an insoluble reaction product which precipitates on flexible electrically conductive nanoelectrodes. The precipitation onto said nanoelectrodes causes a change in their electroconductivity which is accessible to electroanalytical methods. The invention relates further to a biochip comprising a solid support with nanoelectrodes attached thereto and probe molecules bound to all or to a plurality of said nanoelectrodes which may be the same or different, a segment of said probe molecules being able to interact specifically with a segment of the target biomolecules.
Type:
Application
Filed:
March 15, 2004
Publication date:
February 15, 2007
Applicant:
APIBIO SAS
Inventors:
Bernard Mandrand, Agnes Dupont-Filliard
Abstract: The present invention relates to an automated polymer synthesis apparatus for synthesizing a polymer chain onto a solid substrates by sequentially adding polymer building blocks as well as to a method for synthesizing polymers on solid substrates by sequentially reacting polymer building blocks with reactive groups. The invention further relates to a biochip comprising a solid substrate with reactive groups where biomolecules are attached to and the remaining reactive groups are transformed into chemically inert species.
Type:
Application
Filed:
March 1, 2004
Publication date:
November 23, 2006
Applicants:
APIBIO SAS, IMPIKA SA
Inventors:
Alain Laurent, Philippe Sarra-Bournet, Olivier Aude, Paul Morgavi, Bernard Mandrand, Marc Cuzin