Patents Assigned to Applera Corporation
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Patent number: 8246806Abstract: An electrophoresis apparatus includes a multi-capillary array having a liquid or solid disposed between the capillaries of the array. The liquid or solid exhibits a refractive index higher than that of air and less than that of water and reduces the amount of laser beams scattered by the capillaries. Also provided are methods of adjusting refracted and reflected excitation light beams passing through capillaries of a multi-capillary array, to reduce loss of intensity of the laser beams and increase irradiation of respective samples disposed in the capillaries.Type: GrantFiled: March 6, 2007Date of Patent: August 21, 2012Assignees: Applera Corporation, Hitachi, Ltd.Inventors: Ryoji Inaba, Tomohiro Shoji, Shozo Kasai, Masaya Kojima, Yasushi Shimizu, Seiichi Ugai, Eric S. Nordman
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Publication number: 20120190714Abstract: The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.Type: ApplicationFiled: July 27, 2011Publication date: July 26, 2012Applicants: Applera Corporation, ViroBay, Inc.Inventors: Michael Graupe, John O. Link, Michael G. Roepel
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Publication number: 20120122104Abstract: The present disclosure relates to compositions and methods of using triplex structures generated by a duplex of a polypurine tract and complementary polypyrimidine tract and a triplex-forming nucleobase polymer that hydrogen bonds to both the purine and pyrimidine bases of the polypurine-polypyrimidine duplex.Type: ApplicationFiled: March 23, 2007Publication date: May 17, 2012Applicant: Applera CorporationInventors: Neil Straus, Stefan Matysiak, Eric Anderson
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Publication number: 20110315870Abstract: Systems and methods for analyzing compounds in a sample. In one embodiment, the present technology is directed towards a method of analyzing a sample, comprising: emitting ions from the sample; selectively filtering the emitted ions for at least one designated trigger ion; fragmenting the designated trigger ions; scanning for a designated trigger ion fragment; and upon detecting the designated trigger ion fragment, scanning for at least one confirmatory ion fragment.Type: ApplicationFiled: September 9, 2011Publication date: December 29, 2011Applicants: Applera Corporation, MDS Analytical Technologies, a business unit of MDS Inc., doing buiness through its Sciex divisionInventors: Chris M. LOCK, Nic Bloomfield
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Patent number: 8043493Abstract: An electrophoresis apparatus includes a multi-capillary array having a liquid or solid disposed between the capillaries of the array. The liquid or solid exhibits a refractive index higher than that of air and less than that of water and reduces the amount of laser beams scattered by the capillaries. Also provided are methods of adjusting refracted and reflected excitation light beams passing through capillaries of a multi-capillary array, to reduce loss of intensity of the laser beams and increase irradiation of respective samples disposed in the capillaries.Type: GrantFiled: March 6, 2007Date of Patent: October 25, 2011Assignees: Hitachi, Ltd., Applera CorporationInventors: Ryoji Inaba, Tomohiro Shoji, Shozo Kasai, Masaya Kojima, Yasushi Shimizu, Seiichi Ugai
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Publication number: 20110206667Abstract: This invention relates to nucleotide polymorphisms in the human Apo(a) gene and to the use of Apo(a) nucleotide polymorphisms in identifying whether a human subject will respond or not to treatment with acetylsalicylic acid.Type: ApplicationFiled: April 19, 2011Publication date: August 25, 2011Applicants: The Brigham and Women's Hospital, Inc., Applera CorporationInventors: Paul Ridker, Daniel Chasman, Dov Shiffman
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Patent number: 7943317Abstract: This invention relates to nucleotide polymorphisms in the human Apo(a) gene and to the use of Apo(a) nucleotide polymorphisms in identifying whether a human subject will respond or not to treatment with acetylsalicylic acid.Type: GrantFiled: May 9, 2008Date of Patent: May 17, 2011Assignees: The Brigham and Women's Hospital, Inc., Applera CorporationInventors: Paul Ridker, Daniel Chasman, Dov Shiffman
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Publication number: 20110045516Abstract: This invention pertains to methods, kits and/or compositions for the determination of analytes by mass analysis using unique labeling reagents or sets of unique labeling reagents. The labeling reagents can be isomeric or isobaric and can be used to produce mixtures suitable for multiplex analysis of the labeled analytes.Type: ApplicationFiled: January 16, 2007Publication date: February 24, 2011Applicant: Applera CorporationInventors: Darryl J.C. Pappin, Michael Bartlet-Jones
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Publication number: 20110028685Abstract: This invention pertains to methods, mixtures, kits and compositions pertaining to analyte determination and/or quantification by mass spectrometry using compounds comprising a reporter moiety and a non-encoded detectable label. The compounds can be used in sets for the analysis of mixtures of labeled analytes.Type: ApplicationFiled: June 28, 2007Publication date: February 3, 2011Applicant: Applera Corporation.Inventors: Subhasish Purkayastha, Subhakar Dey
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Publication number: 20110003281Abstract: The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more of a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurality of different analytes in a liquid sample. Each chamber may include an analyte-specific reagent effective to react with a selected analyte that may be present in the sample, and detection means for detecting the signal. Also disclosed are methods utilizing the device.Type: ApplicationFiled: June 11, 2007Publication date: January 6, 2011Applicant: Applera CorporationInventors: Timothy Woudenberg, Michael Albin, Reid B. Kowallis, Yefim Raysberg, Robert P. Ragusa, Emily S. Winn-Deen
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Publication number: 20100291548Abstract: The present disclosure relates to methods of identifying target nucleic acids by using coded molecules and its analysis by translocation through a nanopore. Generally, coded molecules are subject to a target polynucleotide dependent modification. The modified coded molecule is detected by isolating the modified coded molecules from the unmodified coded molecules prior to analysis through the nanopore or by detecting a change in the signal pattern of the coded molecule when analyzed through the nanopore.Type: ApplicationFiled: March 12, 2007Publication date: November 18, 2010Applicant: Applera CorporationInventors: Muhammad A. Sharaf, Timothy M. Woudenberg, Khairuzzaman Bashar Mullah
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Publication number: 20100280246Abstract: Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers facilitate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye has the general structure R21Z1C(O)R22R28 where R21 is a C1-5 alkyl attached to the donor dye, C(O) is a carbonyl group, Z1 is either NH, sulfur or oxygen, R22 is a substituent which includes an alkene, diene, alkyne, a five and six membered ring having at least one unsaturated bond or a fused ring structure which is attached to the carbonyl carbon, and R28 includes a functional group which attaches the linker to the acceptor dye.Type: ApplicationFiled: December 28, 2006Publication date: November 4, 2010Applicant: Applera CorporationInventors: Linda G. Lee, Sandra L. Spurgeon, Barnett Rosenblum
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Publication number: 20100261158Abstract: The present disclosure provides apparatus, systems and method for detecting separately and substantially simultaneously light emissions from a plurality of localized light-emitting analytes. A system according to exemplary embodiments of the present disclosure comprises a sample holder having structures formed thereon for spatially separating and constraining a plurality of light-emitting analytes each having a single nucleic acid molecule or a single nucleic acid polymerizing enzyme, a light source configured to illuminate the sample holder, an optical assembly configured to collect and detect separately and substantially simultaneously light emissions associated with the plurality of light emitting analytes. The system may further include a computer system configured to analyze the light emissions to determine the structures or properties of a target nucleic acid molecule associated with each analyte.Type: ApplicationFiled: June 9, 2006Publication date: October 14, 2010Applicant: APPLERA CORPORATIONInventors: Eric S. Nordman, Mark F. Oldham, Timothy Woudenberg
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Publication number: 20100237236Abstract: A method of processing multiple precursor ions in a tandem mass spectrometer includes generating a plurality of precursor ions with an ion source. At least some of the plurality of precursor ions is trapped in an ion trap. At least two precursor ions of interest are isolated from the plurality of precursor ions with a filtered noise field. Precursor ions of interest are sequentially ejected toward a collision cell. The sequentially ejected precursor ions of interest are fragmented in a collision cell. The mass-to-charge ratio spectra of the fragmented ions are then determined with a mass spectrometer.Type: ApplicationFiled: March 20, 2009Publication date: September 23, 2010Applicants: Applera Corporation, MDS, Inc.Inventors: Bruce Thomson, Bruce Collings
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Patent number: 7679053Abstract: A method for introducing samples through a boundary member partially defining a chamber at an entrance point coaxial to a sampling inlet of a mass spectrometer is described. Field-free conditions can be established in at least one region of the chamber. The sample can be introduced adjacent to the sampling inlet, and introducing at least a second sample can be introduced through at least one other entrance point in the chamber not adjacent to the sampling inlet. An apparatus having a sampling inlet and a boundary member partially defining a chamber is also described. Field-free conditions can be established in at least one region of the chamber, and there can be a first aperture in the boundary member through which a source emits sample. Related devices, uses and mass spectrometers are also described.Type: GrantFiled: September 25, 2007Date of Patent: March 16, 2010Assignees: MDS Analytical Technologies, A Business Unit of MDS Inc., Applera CorporationInventors: Bradley B. Schneider, Thomas R. Covey
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Publication number: 20090325158Abstract: 5-bromo-2?-deoxy-uridine (BrdU) labeled nucleotide triphosphates and nucleic acid probes are described herein. The BrdU labeled nucleotide triphosphates include a linker between the nucleotide triphosphate and the BrdU moiety. The linker can be cleavable or non-cleavable. The nucleotide triphosphates can be a ribonucleotide triphosphates, 2?-deoxyribonucleotide triphosphates or 2?,3?-dideoxyribonucleotide triphosphates. The nucleic acid probes can be used for in situ hybridization.Type: ApplicationFiled: June 13, 2008Publication date: December 31, 2009Applicant: APPLERA CORPORATIONInventors: Anilkumar R. Kore, Zhongting Hu
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Publication number: 20090321264Abstract: Embodiments of a device and method are described which provide for concentration and purification of analytes, e.g., polynucleotides, in channel devices using AC and DC electric fields.Type: ApplicationFiled: March 3, 2009Publication date: December 31, 2009Applicant: Applera CorporationInventors: Michael Harrold, Eric S. Nordman
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Publication number: 20090312410Abstract: The present invention is based on the discovery of genetic polymorphisms that are associated with coronary heart disease, specifically MI and including early-onset MI, and response to drug treatment. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.Type: ApplicationFiled: April 20, 2007Publication date: December 17, 2009Applicant: APPLERA CORPORATIONInventors: Dov Shiffman, James J. Devlin
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Publication number: 20090305238Abstract: A fluid processing device is provided that comprises a substrate including a surface and a fluid processing pathway at least partially formed in or on the surface. The fluid processing pathway can comprise a channel, a reaction region in fluid communication with the channel, a microarray in fluid communication with the channel, and optionally a deformable valve. The microarray can comprise binding and/or detection sites, and each site can comprise a binding moiety. A method and a system using the fluid processing device, are also provided.Type: ApplicationFiled: January 22, 2007Publication date: December 10, 2009Applicant: Applera CorporationInventor: David M. Cox
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Publication number: 20090264635Abstract: The present invention concerns a system for isolating, depleting, and/or preventing the amplification of a targeted nucleic acid, such as mRNA or rRNA, from a sample comprising targeted and nontargeted nucleic acids.Type: ApplicationFiled: March 27, 2006Publication date: October 22, 2009Applicant: APPLERA CORPORATIONInventors: Leopoldo Mendoza, Sharmili Moturi, JR., Robert Setterquist, John Penn Whitley