Patents Assigned to Apton Biosystems, Inc.
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Patent number: 11650202Abstract: Methods are provided for detecting a single compound analyte immobilized to a solid substrate by serially contacting and removing different probes to the same analyte.Type: GrantFiled: February 9, 2022Date of Patent: May 16, 2023Assignee: APTON BIOSYSTEMS, INC.Inventors: Bryan P. Staker, Niandong Liu, Bart Lee Staker, Michael David McLaughlin
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Patent number: 11474107Abstract: Electrical detection methods are used to identify and further characterize single-molecule target analytes such as proteins and nucleic acids. A composition including a probe region and a tail region is contacted with a target analyte. The probe region specifically binds to the target analyte. The tail region is coupled to the probe region, and includes a nucleic acid template for polynucleotide synthesis. When conditions are such that polynucleotide synthesis occurs along the tail region, one hydrogen ion is released for every nucleotide that is incorporated into the tail region. A transistor such as an ISFET detects and measures changes in ion concentration, and these measurements can be used to identify the tail region and thus characterize the corresponding target analyte.Type: GrantFiled: March 16, 2022Date of Patent: October 18, 2022Assignee: APTON BIOSYSTEMS, INC.Inventors: Bryan P. Staker, Niandong Liu, Bart Lee Staker, Michael David McLaughlin
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Patent number: 11434532Abstract: Disclosed herein are methods and systems for detection and discrimination of optical signals from a densely packed substrate. There have broad applications for biomolecule detection near or below the diffraction limit of optical systems, including in improving the efficiency and accuracy or polynucleotide sequencing applications.Type: GrantFiled: May 21, 2021Date of Patent: September 6, 2022Assignee: APTON BIOSYSTEMS, INC.Inventors: Bryan P. Staker, Niandong Liu, Manohar R. Furtado, Rixun Fang, Norman Burns, Windsor Owens
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Patent number: 11435356Abstract: Electrical detection methods are used to identify and further characterize single-molecule target analytes such as proteins and nucleic acids. A composition including a probe region and a tail region is contacted with a target analyte. The probe region specifically binds to the target analyte. The tail region is coupled to the probe region, and includes a nucleic acid template for polynucleotide synthesis. When conditions are such that polynucleotide synthesis occurs along the tail region, one hydrogen ion is released for every nucleotide that is incorporated into the tail region. A transistor such as an ISFET detects and measures changes in ion concentration, and these measurements can be used to identify the tail region and thus characterize the corresponding target analyte.Type: GrantFiled: February 17, 2021Date of Patent: September 6, 2022Assignee: APTON BIOSYSTEMS, INC.Inventors: Bryan P. Staker, Niandong Liu, Bart Lee Staker, Michael David McLaughlin
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Patent number: 11248266Abstract: Disclosed herein are methods and systems for detection and discrimination of optical signals from a densely packed substrate. These have broad applications for biomolecule detection near or below the diffraction limit of optical systems, including in improving the efficiency and accuracy of polynucleotide sequencing applications.Type: GrantFiled: October 1, 2020Date of Patent: February 15, 2022Assignee: APTON BIOSYSTEMS, INC.Inventors: Bryan P. Staker, Niandong Liu, Michael David McLaughlin, Bart Lee Staker
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Patent number: 11060140Abstract: Disclosed herein are methods and systems for detection and discrimination of optical signals from a densely packed substrate. These have broad applications for biomolecule detection near or below the diffraction limit of optical systems, including in improving the efficiency and accuracy of polynucleotide sequencing applications.Type: GrantFiled: July 1, 2019Date of Patent: July 13, 2021Assignee: APTON BIOSYSTEMS, INC.Inventors: Bryan P. Staker, Niandong Liu, Manohar R. Furtado, Rixun Fang, Norman Burns, Windsor Owens
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Patent number: 11047005Abstract: Disclosed herein are methods and systems for detection and discrimination of optical signals from a densely packed substrate. These have broad applications for biomolecule detection near or below the diffraction limit of optical systems, including in improving the efficiency and accuracy of polynucleotide sequencing applications.Type: GrantFiled: October 29, 2020Date of Patent: June 29, 2021Assignee: APTON BIOSYSTEMS, INC.Inventors: Bryan P. Staker, Niandong Liu, Manohar R. Furtado, Rixun Fang, Norman Burns, Windsor Owens
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Patent number: 10829816Abstract: Disclosed herein are methods and systems for detection and discrimination of optical signals from a densely packed substrate. These have broad applications for biomolecule detection near or below the diffraction limit of optical systems, including in improving the efficiency and accuracy of polynucleotide sequencing applications.Type: GrantFiled: September 16, 2019Date of Patent: November 10, 2020Assignee: APTON BIOSYSTEMS, INC.Inventors: Bryan P. Staker, Niandong Liu, Michael David McLaughlin, Bart Lee Staker
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Patent number: 10585296Abstract: Disclosed herein is a high throughput optical scanning device and methods of use. The optical scanning device and methods of use provided herein can allow high throughput scanning of a continuously moving object with a high resolution despite fluctuations in stage velocity. This can aid in high throughput scanning of a substrate, such as a biological chip comprising fluorophores. Also provided herein are improved optical relay systems and scanning optics.Type: GrantFiled: March 2, 2018Date of Patent: March 10, 2020Assignee: APTON BIOSYSTEMS, INC.Inventors: Windsor Owens, Bryan Staker, Rob Hartlage, Edvinas Zizminskas, David Stern, Paul Heilman
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Patent number: 10378053Abstract: Disclosed herein are methods and systems for detection and discrimination of optical signals from a densely packed substrate. These have broad applications for biomolecule detection near or below the diffraction limit of optical systems, including in improving the efficiency and accuracy of polynucleotide sequencing applications.Type: GrantFiled: March 19, 2018Date of Patent: August 13, 2019Assignee: Apton Biosystems, Inc.Inventors: Bryan P. Staker, Niandong Liu, Manohar R. Furtado, Rixun Fang, Norman Burns, Windsor Owens
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Publication number: 20160201119Abstract: Electrical detection methods are used to identify and further characterize single-molecule target analytes such as proteins and nucleic acids. A composition including a probe region and a tail region is contacted with a target analyte. The probe region specifically binds to the target analyte. The tail region is coupled to the probe region, and includes a nucleic acid template for polynucleotide synthesis. When conditions are such that polynucleotide synthesis occurs along the tail region, one hydrogen ion is released for every nucleotide that is incorporated into the tail region. A transistor such as an ISFET detects and measures changes in ion concentration, and these measurements can be used to identify the tail region and thus characterize the corresponding target analyte.Type: ApplicationFiled: August 21, 2014Publication date: July 14, 2016Applicant: Apton Biosystems, Inc.Inventors: Bryan Staker, Niandong Liu, Bart Lee McLaughlin