Abstract: The present invention is related to a method for determining mucosa alterations in a subject, in particular to a method for determining mucosa alterations in a sample using a reagent comprising a lanthanide(III) ion, and an array of indicator molecules configured to interact with the sample. The reagent comprising the lanthanide(III) ion does not have any sample or indicator molecule specific recognition elements. The invention relates also to an array for determining mucosa alterations, the array comprising one or more indicator molecules configured to interact specifically with the sample and a reagent comprising a lanthanide(III) ion. The reagent comprising a lanthanide(III) does not have any sample or indicator molecule specific recognition elements.

Abstract: A method for determining samples including one or more organic polymers by mixing them with lanthanide(III) ions and detecting the signal of the lanthanide(III) ion chelated with the organic polymer.

Abstract: An apparatus and method are disclosed for examining optically a sample carried in a plurality of wells. A holder is adapted to receive and hold in place a sample carrier. A plurality of excitation means selectively introduce excitation towards a spatially limited portion of a sample carrier held in place by said holder. Detecting means receive and detect emission radiation coupled out from a light output window of a sample carrier held in place by said holder. Said detecting means is common to said excitation means and is configured to receive emission radiation from a plurality of different spatially limited portions of a sample carrier held in place by said holder.

Abstract: A separation-free assay including a binding partner, a binding partner labeled with a directly luminescent label, and a nonspecifically binding label able to affect the signal of the unbound labeled binding partner, in which a signal of the binding partner label or the signal of the nonspecific binding label is measured in a binding event, and where at least one of the binding partners is a mobile binding partner.

Abstract: A device is provided for holding a sample for optical examination. The device comprises a body that defines a plurality of spots or wells. One or more non-specific interacting surfaces in the spots or wells are capable of non-specific binding of a said sample, a luminophore label, or their combination. A light conducting layer comprises material that is essentially non-transparent to optical excitation radiation and essentially transparent to optical luminescent radiation. A light input window couples luminescent light into said light conducting layer, and a light output window couples light out from said light conducting layer.

Abstract: A device for holding a sample for optical fingerprinting analysis comprises a carrier, and a distribution of non-specific interacting surfaces extending across said carrier. At least one fluidic channel allows a fluid sample to flow through at least a part of said carrier to get in touch with one or more of said non-specific interacting surfaces. One or more optical windows adjacent to said non-specific interacting surfaces enable optical analysis of results of said sample getting in touch with said non-specific interacting surfaces at multiple locations of the carrier.

Abstract: An apparatus and method are disclosed for examining optically a sample carried in a plurality of wells. A holder is adapted to receive and hold in place a sample carrier. A plurality of excitation means selectively introduce excitation towards a spatially limited portion of a sample carrier held in place by said holder. Detecting means receive and detect emission radiation coupled out from a light output window of a sample carrier held in place by said holder. Said detecting means is common to said excitation means and is configured to receive emission radiation from a plurality of different spatially limited portions of a sample carrier held in place by said holder.

Abstract: Characterizing and/or determining a sample employs an array of at least two of different interacting surfaces, at least one of which comprises a non-specific interacting material non-specifically interacting said sample, at least one labelling reactant, and/or combination of the sample and at least one labelling reactant. The sample and at least one labelling reactant is introduced to interact with said interacting surfaces of said array, wherein said labelling reactant is adapted to change at least one electromagnetically readable property of at least one interacting surface of said array.