Abstract: The present invention generally relates to devices for deploying intraocular shunts without the use of an optical apparatus that contacts an eye, such as a goniolens. In certain embodiments, devices of the invention include a housing including a proximal portion and a distal portion, in which the distal portion is movable within the proximal portion, a deployment mechanism at least partially disposed within the housing, and a hollow shaft coupled to the deployment mechanism, in which the shaft is configured to hold an intraocular shunt.

Abstract: An intraocular shunt can be manufactured using a system that includes a liquid bath and a wire, which is moved through the bath. When moved through the bath, the wire is coated with a material, such as gelatin. For example, the liquid bath can have a top layer, including water, and a bottom layer, including gelatin. The coated wire passes through an aperture formed in a plate component of the system. The gelatin can be dried on the wire in a humidity-controlled space, thereby forming the shunt.

Abstract: An inserter for treating glaucoma can comprise a housing, a needle, a plunger, a slider component, and a drive component. The drive component is disposed within a cavity of the housing and rotatable within the cavity to result in movement along a longitudinal axis of the inserter to the needle and the plunger upon rotation of the drive component. The slider component is coupled to the housing and slidable along an elongate groove of the drive component such that movement of the slider component along the axis rotates the drive component within the housing.

Abstract: The present invention generally relates to intraocular shunts, and in particular, to intraocular shunts configured to form a drainage pathway between the anterior chamber and the intra-Tenon's space.

Abstract: The present invention generally relates to methods for treating closed angle glaucoma. In certain embodiments, methods of the invention involve inserting into an eye a deployment device configured to hold an intraocular shunt, using the device to re-open an at least partially closed anterior chamber angle of an eye, and deploying the shunt from the device.

Abstract: The present invention generally relates to intraocular shunts, and in particular, to intraocular shunts configured to form a drainage pathway between the anterior chamber and the intra-scleral space.

Abstract: The present invention generally relates to the reduction of intraocular pressure, and in particular, to methods for treating glaucoma by insertion of an intraocular shunt in the eye such that it forms a drainage pathway between the anterior chamber and the intra-Tenon's space.

Abstract: The invention generally relates to methods for implanting a soft gel shunt in the suprachoroidal space. In certain embodiments, methods of the invention involve inserting into the eye a hollow shaft configured to hold a soft gel intraocular shunt, deploying the soft gel shunt from the hollow shaft such that the shunt forms a passage from the anterior chamber of the eye to the suprachoroidal space of the eye, and withdrawing the hollow shaft from the eye.

Abstract: The present invention generally relates to devices for deploying intraocular shunts without the use of an optical apparatus that contacts an eye, such as a goniolens. In certain embodiments, devices of the invention include a housing, in which a distal end of the housing includes a protrusion, a deployment mechanism at least partially disposed within the housing, and a hollow shaft coupled to the deployment mechanism, in which the shaft is configured to hold an intraocular shunt.

Abstract: The present invention generally relates to devices and methods of implanting an intraocular shunt into an eye. In certain aspects, methods of the invention involve creating an opening in the sclera, and positioning a shunt in the anterior chamber of the eye such that the shunt terminates via the opening in the intra-scleral space, thereby facilitating fluid flow through both the opening and the intra-scleral space.

Abstract: Methods and devices for adjusting or configuring the flow rate of an intraocular shunt are provided whereby hypotony can be avoided by increasing the flow rate through the device. In some embodiments, the device is a shunt that can have a first flow that can be modified to a second flow by modifying the shunt, such as by cutting the shunt. Additionally, one or more dissolvable portions can be present to provide an initial flow restriction and subsequent increase in flow over time.

Abstract: Methods and devices for adjusting or configuring the flow rate of an intraocular shunt are provided whereby hypotony can be avoided by increasing the flow rate through the device. In some embodiments, the device is a shunt that can have a first flow that can be modified to a second flow by modifying the shunt, such as by cutting the shunt. Additionally, one or more dissolvable portions can be present to provide an initial flow restriction and subsequent increase in flow over time.

Abstract: The present invention generally relates to devices for deploying intraocular shunts without the use of an optical apparatus that contacts an eye, such as a goniolens. In certain embodiments, devices of the invention include a housing, a deployment mechanism at least partially disposed within the housing, and a hollow shaft coupled inside the housing to the deployment mechanism, in which the shaft is configured to hold an intraocular shunt, and the device includes an insertion configuration and a deployment configuration and the insertion configuration involves the shaft being fully disposed within the housing.

Abstract: The invention generally relates to systems and methods for making gelatin shunts. In certain embodiments, the invention provides methods that may involve moving a wire through a bath including a bottom layer of liquid gelatin and a top layer of water, thereby coating the wire with gelatin, moving the gelatin coated wire through an aperture, and drying the gelatin on the wire in a humidity controlled space, thereby manufacturing a gelatin shunt. In other embodiments, the invention provides systems that may include a motor, a wire operable coupled to the motor for movement of the wire, a temperature controllable bath, an aperture plate situated in a top portion of the bath, and an ultrasonic fogger, in which the system is configured such that the wire moves through the bath, through the aperture plate, and into the ultrasonic fogger.

Abstract: Methods are provided for using an intraocular shunt deployment device to deploy an intraocular shunt from the device and into an eye.

Abstract: The invention generally relates to devices and methods for implanting a shunt in the suprachoroidal space of an eye. In certain aspects, devices of the invention include a housing, a deployment mechanism at least partially disposed within the housing, and a flexible hollow shaft coupled to the deployment mechanism, in which the shaft holds an intraocular shunt, and is configured to self-guide the shunt along a scleral spur of an eye as the shunt is deployed from the shaft. Such a device may be inserted into an eye and used to deploy a shunt within the eye such that a proximal portion of the shunt receives fluid from an anterior chamber of an eye and a distal portion of the shunt directs the fluid to the suprachoroidal space.

Abstract: The invention generally relates to devices for deploying an intraocular shunt within an eye. In certain embodiments, devices of the invention include a housing, a deployment mechanism at least partially disposed within the housing, and a hollow shaft coupled to the deployment mechanism, in which the shaft is configured to hold an intraocular shunt, and in which rotation of the deployment mechanism results in deployment of the shunt.

Abstract: The invention generally relates to methods for using an intraocular shunt deployment device to deploy an intraocular shunt from the device and into an eye.

Abstract: The present invention generally relates to intraocular shunts, and in particular, to intraocular shunts configured to form a drainage pathway between the anterior chamber and the intra-Tenon's space.

Abstract: The present invention generally relates to systems for deploying intraocular shunts without the use of an optical apparatus that contacts an eye, such as a goniolens. In certain embodiments, systems of the invention include a locking mechanism, and a device configured to hold and deploy an intraocular shunt, in which a distal portion of the device is movable within a proximal portion of the device and the distal portion of the device is configured to mate with the locking mechanism to prevent movement of the distal portion when the locking mechanism is engaged.