Abstract: A highly-sulfated modified fucan comprising a therapeutically effective, medically acceptable fucan in a composition comprising a sulfate to fucose molar ratio of greater than or equal to about 1.2, 1.81 or 1.9 and/or a sulfate to fucose plus galactose molar ratio of greater than or equal to about 1.1, 1.2 or 1.3.
Type:
Grant
Filed:
July 24, 2019
Date of Patent:
September 20, 2022
Assignee:
ARC Medical Devices
Inventors:
Christopher Michael Kevin Springate, Sailesh Haresh Daswani
Abstract: High-molecular-weight fucan compositions comprising a therapeutically effective, medically acceptable fucan in a composition comprising wherein the fucan, for example, has a molecular weight distribution in which more than 60% w/w of the composition has a molecular weight above 100 kDa.
Type:
Grant
Filed:
July 24, 2019
Date of Patent:
August 23, 2022
Assignee:
ARC Medical Devices Inc.
Inventors:
Christopher Michael Kevin Springate, Ian Millet, Sailesh Haresh Daswani, Hesong Sun
Abstract: Apparatus, methods, systems, etc., for the tangential flow filtration (TFF) of viscous compositions including viscous fluids, solutions, gels, pastes, creams and suspensions with viscosities greater than 10 cP, 20 cP, 50 cP or 100 cP. The methods, etc., provide enhanced mixing of the viscous compositions in their storage vessels by extracting the input composition from different depths in the storage vessels to reduce or eliminate vertical concentration gradients.
Abstract: Methods, systems etc., for predicting and/or consistently obtaining uniform biopolymer compositions by blending a plurality of input biopolymer compositions with different molecular weight distributions, the blending based on concentration data as a function of molecular weight for the plurality of input biopolymer compositions.
Abstract: Low endotoxin fucan compositions comprising a therapeutically effective, medically acceptable fucan in a composition comprising less than about 0.2, 0.18, 0.1, 0.01, 0.001, or 0.0005 endotoxin units (EU) per milligram of the fucan are disclosed. Methods and systems for removing or reducing the amount of endotoxins from a starting fucan composition are also disclosed.
Type:
Application
Filed:
July 24, 2019
Publication date:
September 30, 2021
Applicant:
ARC Medical Devices Inc.
Inventors:
Christopher Michael Kevin Springate, Ian Millet, Sailesh Haresh Daswani, Hesong Sun, Aileen Shao Ting Yang, Hoi Ting Wong
Abstract: Compositions, methods, systems, etc., are provided for modified and/or purified fucans and corresponding fucan-containing compositions that inhibit fibrous adhesions among other advantages. The purified/modified fucans and fucan compositions have a reduced level of non-fucan components or impurities such as those found in a starting fucan composition. Such reduced undesirable components or impurities include, for example, undesired components bound to the fucan and compounds in the composition that are not a part of or bound to the fucan.
Type:
Application
Filed:
July 24, 2019
Publication date:
September 23, 2021
Applicant:
ARC Medical Devices Inc.
Inventors:
Christopher Michael Kevin Springate, Ian Millet, Sailesh Haresh Daswani, Hesong Sun, Aileen Shao Ting Yang, Hoi Ting Wong
Abstract: A highly-sulfated modified fucan comprising a therapeutically effective, medically acceptable fucan in a composition comprising a sulfate to fucose molar ratio of greater than or equal to about 1.2, 1.81 or 1.9 and/or a sulfate to fucose plus galactose molar ratio of greater than or equal to about 1.1, 1.2 or 1.3.
Type:
Application
Filed:
July 24, 2019
Publication date:
September 23, 2021
Applicant:
ARC Medical Devices Inc.
Inventors:
Christopher Michael Kevin Springate, Bryan Young, Sailesh Haresh Daswani
Abstract: Compositions, methods, systems, etc., are provided for modified and/or purified fucans and corresponding fucan-containing compositions that inhibit fibrous adhesions among other advantages. The purified/modified fucans and fucan compositions have a reduced level of non-fucan components or impurities such as those found in a starting fucan composition. Such reduced undesirable components or impurities include, for example, undesired components bound to the fucan and compounds in the composition that are not a part of or bound to the fucan.
Type:
Application
Filed:
July 24, 2019
Publication date:
September 23, 2021
Applicant:
ARC Medical Devices Inc.
Inventors:
Christopher Michael Kevin Springate, Ian Millet, Sailesh Haresh Daswani, Hesong Sun, Aileen Shao Ting Yang, Hoi Ting Wong
Abstract: High-molecular-weight fucan compositions comprising a therapeutically effective, medically acceptable fucan in a composition comprising wherein the fucan, for example, has a molecular weight distribution in which more than 60% w/w of the composition has a molecular weight above 100 kDa.
Type:
Application
Filed:
July 24, 2019
Publication date:
September 23, 2021
Applicant:
ARC Medical Devices Inc.
Inventors:
Christopher Michael Kevin Springate, Ian Millet, Sailesh Haresh Daswani, Hesong Sun
Abstract: Compositions and methods involving administration of agents useful for the treatment, prevention, inhibition, etc., of inflammatory disease or fibrous adhesions using low sulphate fucans and, if desired, one or more other anti-inflammatory disease or anti-fibrous adhesion agent.
Type:
Application
Filed:
December 9, 2019
Publication date:
October 29, 2020
Applicant:
ARC Medical Devices Inc.
Inventors:
Johanne Cashman, Christopher Michael Kevin Springate, Charles Winternitz
Abstract: Compositions and methods relating to fucan agents useful for the treatment, prevention, inhibition, etc., of fibrous adhesions or other diseases.
Abstract: Compositions, systems, methods, etc., related to fucan-dendrimer complexes wherein a fucan molecule is linked or otherwise attached to a dendrimer. For example, the current compositions can comprise fucan covalently linked, conjugated, attached, tagged, adducted, bound, etc., to a dendrimer. These fucan-dendrimer complexes include fucan-hyperbranched polyglycerol, fucan-hyperbranched poly(glycerol ester), fucan-hyperbranched poly(1,3-diether), fucan-poly(3-ethyl-3-(hydroxymethyl)oxetane), fucan-hyperbranched polyesters, fucan-hyperbranched polyethylene, fucan-hyperbranched polystyrene, fucan-hyperbranched poly(urea-urethanes), fucan-hyperbranched polyethyleneimine, fucan-hyperbranched poly(amido amine)s, fucan-hyperbranched polyphosphates, fucan-hyperbranched polypeptides, fucan-hyperbranched polysaccharides, fucan-hyperbranched polyacrylates and fucan-hyperbranched beta-cyclodextrin.
Abstract: Compositions and methods relating to fucan agents useful for the treatment, prevention, inhibition, etc., of fibrous adhesions or other diseases.
Abstract: Compositions and methods relating to fucan agents useful for the treatment, prevention, inhibition, etc., of fibrous adhesions or other diseases.
Abstract: Compositions and methods involving administration of agents useful for the treatment, prevention, inhibition, etc., of inflammatory disease or fibrous adhesions using low sulphate fucans and, if desired, one or more other anti-inflammatory disease or anti-fibrous adhesion agent.
Type:
Application
Filed:
October 3, 2016
Publication date:
September 7, 2017
Applicant:
ARC Medical Devices, Inc.
Inventors:
Johanne Cashman, Christopher Michael Kevin Springate, Charles Winternitz
Abstract: Compositions and methods involving administration of agents useful for the treatment, prevention, inhibition, etc., of inflammatory disease or fibrous adhesions using low sulphate fucans and, if desired, one or more other anti-inflammatory disease or anti-fibrous adhesion agent.
Type:
Application
Filed:
October 3, 2016
Publication date:
August 31, 2017
Applicant:
ARC Medical Devices, Inc.
Inventors:
Johanne Cashman, Christopher Michael Kevin Springate, Charles Winternitz
Abstract: Compositions and methods involving administration of agents useful for the treatment, prevention, inhibition, etc., of inflammatory disease or fibrous adhesions using low sulphate fucans and, if desired, one or more other anti-inflammatory disease or anti-fibrous adhesion agent.
Type:
Application
Filed:
April 15, 2013
Publication date:
September 11, 2014
Applicant:
Arc Medical Devices, Inc.
Inventors:
Johanne Cashman, Christopher Michael Kevin Springate, Charles Winternitz
Abstract: Compositions and methods involving administration of agents useful for the treatment, prevention, inhibition, etc., of inflammatory disease or fibrous adhesions using low sulphate fucans and, if desired, one or more other anti-inflammatory disease or anti-fibrous adhesion agent.
Type:
Application
Filed:
May 13, 2013
Publication date:
May 15, 2014
Applicant:
Arc Medical Devices, Inc.
Inventors:
Johanne Cashman, Christopher Michael Kevin Springate, Charles Winternitz
Abstract: Compositions and methods relating to fucan agents useful for the treatment, prevention, inhibition, etc., of fibrous adhesions or other diseases.
Abstract: Compositions and methods relating to fucan agents useful for the treatment, prevention, inhibition, etc., of fibrous adhesions or other diseases.