Abstract: What is described is a trinucleotide cap analog comprising m7G(5?)p3-N1pN2 for increased efficiency of in vitro transcription of m7G(5?)p3-RNA, wherein m7G is N7-methylguanosine or analog, (5?)p3 is a 5?,5?-triphosphate bridge, and N1 or N2 or both ribonucleotide analogs linked to each other by a phosphate, p, and wherein the trinucleotide cap analog increases the efficiency of in vitro transcription.

Abstract: Methods and systems to configure computer program logic knowledge modules (KNOMs) in response to user selections. A KNOM may be configured to cause a processor to measure and/or monitor one or more processes or properties, and to perform one or more functions when a corresponding condition is satisfied, such as to provide a recommendation and/or to implement change. A KNOM may be configured with respect to one or more processes running within a corresponding computer environment, such as a WebLogic environment, and/or an external environment. KNOMs may be shared amongst users within a networked community, and may be combined into KNOM packages, such as to combine expert knowledge from a plurality of users. Peer-based ranking information may be associated with KNOMs and/or users.