Abstract: A method for the topical or systemic treatment of disorders mediated by proteases which result in skin or mucosal lesions, and in particular, pemphigus, cicatricial pemphigoid, bullous pemphigoid, lichen planus, and canker sores, is disclosed wherein the host is treated with an effective amount of N-acetyl ysteine or a derivative thereof, or its pharmaceutically acceptable salt, optionally in a pharmaceutically acceptable diluent or carrier for systemic or topical delivery.
Type:
Grant
Filed:
October 5, 1993
Date of Patent:
June 10, 1997
Assignee:
Arcturus Pharmaceutical Corporation
Inventors:
Richard J. Sharpe, Maureen H. McAloon, Stephen J. Galli, Kenneth A. Arndt