Patents Assigned to ARGINETIX, INC.
  • COMPOSITIONS AND METHODS OF TREATING ENDOTHELIAL DISORDERS
    Publication number: 20120065165
    Abstract: Compositions and methods of treating endothelial disorders, including: asthma, erectile dysfunction, pulmonary hypertension, cardiovascular disorders, and other disorders, using a synergistic combination of at least one arginase inhibitor and at least one phosphodiesterase (PDE1), (PDE2) and/or (PDE5) inhibitor are described.
    Type: Application
    Filed: November 2, 2009
    Publication date: March 15, 2012
    Applicant: ARGINETIX, INC
    Inventors: Simon E. Aspland, Dan E. Berkowitz, Trinity Bivalacqua, Hunter Champion
  • ARGINASE INHIBITORS AND METHODS OF USE
    Publication number: 20100189644
    Abstract: The present invention is directed to arginase inhibitor compounds of formula IA or formula IB: or a pharmaceutically acceptable salt thereof, compositions containing these compounds, and methods of their use for the treatment and diagnosis of conditions characterized by upregulation of arginase, abnormally high arginase activity, or by abnormally low nitric oxide synthase activity.
    Type: Application
    Filed: January 26, 2010
    Publication date: July 29, 2010
    Applicants: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, ARGINETIX, INC.
    Inventors: DAVID W. CHRISTIANSON, Bruce Edward Tomczuk, Richard Scott Pottorf, Andrew Vargha Colasanti, Gary Lee Olson