Abstract: The present invention provides assays systems and methods for detection of chromosomal abnormalities and status of single loci associated with monogenic or polygenic traits in a sample containing nucleic acids from a maternal and a fetal source.
Abstract: The present invention provides assay systems and related methods for determining genetic abnormalities in mixed samples comprising cell free DNA from both normal and putative genetically atypical cells. Exemplary mixed samples for analysis using the assay systems of the invention include samples comprising both maternal and fetal cell free DNA and samples that contain DNA from normal cells and circulating cancerous cells.
Type:
Application
Filed:
January 23, 2012
Publication date:
July 26, 2012
Applicant:
Aria Diagnostics, Inc.
Inventors:
Arnold Oliphant, Andrew Sparks, Ken Song, John Stuelpnagel
Abstract: The present invention provides processes for determining accurate risk probabilities for fetal aneuploidies. Specifically, the invention provides non-invasive evaluation of genomic variations through chromosome-selective sequencing and non-host fraction data analysis of maternal samples.
Type:
Application
Filed:
December 28, 2011
Publication date:
July 26, 2012
Applicant:
Aria Diagnostics, Inc.
Inventors:
Arnold Oliphant, Andrew Sparks, Eric Wang, Craig Struble
Abstract: The present invention provides processes for determining accurate risk probabilities for chromosome dosage abnormalities. Specifically, the invention provides non-invasive evaluation of genomic variations through chromosome-selective sequencing and non-host fraction data analysis of maternal samples.
Type:
Application
Filed:
December 9, 2011
Publication date:
July 26, 2012
Applicant:
Aria Diagnostics, Inc.
Inventors:
Arnold Oliphant, Andrew Sparks, Eric Wang, Craig Struble
Abstract: The present invention provides assay systems and related methods for determining genetic abnormalities in mixed samples comprising cell free DNA from both normal and putative genetically atypical cells. Exemplary mixed samples for analysis using the assay systems of the invention include samples comprising both maternal and fetal cell free DNA and samples that contain DNA from normal cells and circulating cancerous cells.
Type:
Application
Filed:
January 23, 2012
Publication date:
July 26, 2012
Applicant:
Aria Diagnostics, Inc.
Inventors:
Arnold Oliphant, Andrew Sparks, Ken Song, John Stuelpnagel