Abstract: Provided herein are methods and compositions for preparing nucleic acid templates wherein spatial-proximal and molecular contiguity of target nucleic acids is preserved, and the sequencing data obtained therefrom is used, but not limited to, identification of genomic variants, determination of contiguity information to inform assemblies of target nucleic acids de novo including deconvolution of haplotype phase information, and analyses of conformation and topology of target nucleic acids.
Type:
Grant
Filed:
November 20, 2018
Date of Patent:
January 16, 2024
Assignee:
Arima Genomics, Inc.
Inventors:
Siddarth Selvaraj, Anthony Schmitt, Bret Reid
Abstract: Provided herein are methods and compositions for preparing nucleic acids in samples that preserve spatial-proximal contiguity information. Samples include, but are not limited to, formalin-fixed paraffin-embedded (FFPE) samples, deeply formalin-fixed samples and samples that comprise protein:cfDNA complexes.
Type:
Grant
Filed:
November 19, 2019
Date of Patent:
June 28, 2022
Assignee:
ARIMA GENOMICS, INC.
Inventors:
Anthony Schmitt, Catherine Tan, Derek Reid, Chris De La Torre, Siddarth Selvaraj