Abstract: Alcohol soluble complexes of basic aluminum bromides may be prepared by adding zirconyl or zinc bromide or chloride, or zirconyl hydroxychloride or hydroxybromide, or mixtures of the above chlorides and bromides to an aqueous solution of five-sixths basic aluminum bromide, and drying the resulting mixture to a substantially friable solid, such as by vacuum or spray drying. The complexes preferably have an Al/Zn or Al/Zr mol ratio of about 3:1 to 20:1, and the complex solids preferably contain about 15 to 30 weight percent water by Karl Fischer analysis. Such complex solids have a high degree of solubility in anhydrous alcohol and a high compatibility with halogenated hydrocarbons. These properties make the complexes suitable for aerosol formulations and particularly antiperspirant compositions.
Type:
Grant
Filed:
June 3, 1975
Date of Patent:
March 30, 1976
Assignee:
Armour Pharmaceutical Company
Inventors:
John L. Jones, Andrew M. Rubino, Charles B. Lindahl
Abstract: The purification of plasminogen from human and non-human mammalian plasma or Cohn Fraction III by modified affinity chromotography using Sepharose-L-lysine with high ionic strength buffer solutions as in ion exchange chromatography is described. A plasminogen is produced in great yield having unexpectedly enhanced activity toward N.sup..alpha.-CBZ-L-lysine p-nitrophenyl ester, enhanced fibrinolytic activity and significantly less contamination by unknown colloidal substances.