Abstract: An ultrasound probe includes a reverberator having a randomly uneven shape preferably including a plurality of facets. Together with a rigid coupling window, it forms a closed cavity filled with reverberation medium such as water. One or more ultrasound transducers are placed inside the reverberator to generate a signal using time-reversed acoustics principles. Additional transducers increase the power output of the probe. An optional transducer design features a piezomaterial formed in a randomly uneven shape, preferably having length/thickness ratio of at least 2. The reverberator cavity further includes scatterers suspended inside and aimed at improving the focusing quality of the probe. Such scatterers can be of various sizes and in a number of shapes such as beads, cylinders and membranes. The probe can be advantageously used for focusing broadband ultrasonic waves in various industrial and medical applications such as those utilizing high intensity short ultrasonic pulses.

Abstract: Ultrasound-assisted contactless stirring of liquids in a resonator cell by microparticles is achieved by repeated creating and destruction of nodal patterns associated with standing waves of various resonance frequencies causing continuous movements of microparticles inside the cell. Swept-frequency sonication methods include using constant or variable rate of frequency change as well as a stepwise change of frequency of the transducer within a predefined range. Other useful steps include initial detection of the set of resonance frequencies and periodic refreshing of that set. Control systems are described including means to automatically detect the resonance frequencies and maintain the operation of the transducer thereon. Advantageous designs of the apparatus are described for use in microstirring, mixing of liquids using magnetic microbeads, microbubbles, microtiter plates, microarray plates, etc.

Abstract: An Internet-based system is described including a number of patient terminals equipped with tactile imaging probes to allow conducting of breast examinations and collecting the 2-D digital data from the pressure arrays of the tactile imaging probes. The digital data is processed at the patient side including a step of detecting moving objects and discarding the rest of the data from further analysis. The data is then formatted into a standard form and transmitted over the Internet to the host system where it is accepted by one of several available servers. The host system includes a breast examination database and a knowledge database and is designed to further process, classify, and archive breast examination data. It also provides access to processed data from a number of physician terminals equipped with data visualization and diagnosis means.

Abstract: Disclosed devices and methods for droplet microchromatograhy are aimed at optical monitoring and rapid analysis of a drying droplet. The device includes droplet deposition component preferably made as a modified disk adapted to fit in a modified CD disk drive, an optical recorder, and a computer control and image analysis. Recorded timed sequence of images of the process of drying of the droplet is digitally filtered and analyzed using windows selected in each image. Changes of predetermined parameters in each window for each image are calculated to assess temporal and spatial dynamics within the sequence of images reflecting sedimentary pattern formation of a drying droplet. Humidity can be selectively controlled to slow down the drying process allowing “zooming” onto the critical periods of drying of the droplet. Various chemical coatings of the deposition means can be used to enhance the test further.

Abstract: Methods and apparatus are disclosed for non-invasive bone evaluation based on a broadband ultrasonic transducer emitting a train of ultrasonic wave packets of multiple carrier frequencies ranging from about 50 kHz to about 2 MHz. Receiving broadband ultrasonic transducer accepts broadband ultrasonic signal propagated through the bone. Computer processing means provide for data analysis and feature extraction allowing diagnostic evaluation of the bone, including comparing the features of the received signal to a database of known bone conditions.

Abstract: Disclosed are human tissue phantoms mimicking the mechanical properties of real tissue, and methods for manufacturing thereof including the steps of obtaining a computer aided three-dimensional design of a phantom mimicking the tissue in shape and size; fabrication of a mold form facilitating the production of the designed phantom; molding said phantom with the use of two-component silicon gels as a bulk tissue-mimicking material having Young's modulus in the range of 2 to 30 kPa; filling the enclosed volume of said phantom with anatomical and pathological tissue structures mimicking their respective mechanical properties and having Young's modulus in the range of about 30 to 600 kPa; covering said phantom by a protective layer having mechanical properties to a human tissue protective layer; and securing the phantom perimeter on a supporting plate by a rubber barrier.

Abstract: A device and method for determining the hydration and water content status of soft biological tissue is disclosed and includes a couple of ultrasonic transducers located at a known distance therebetween and held against the tissue of interest as well as an adjustable support system with angle measuring means necessary for evaluation of ultrasound velocity in this tissue. Based on the time-of-flight results of the ultrasound velocity measurement, the water content in the tested tissue is evaluated and the hydration status is determined. One embodiment of the invention is a wearable device attached to human calf measuring water content in muscle.

Abstract: Abstract of the Disclosure Devices for optical monitoring and rapid analysis of a drying droplet are presented and include a droplet deposition means, an optical recording means, and a computer control and image analysis means. In several preferred embodiments, a pipette is used to deposit one or more droplets in parallel onto a slide, a plate or a film, and a digital microscope is positioned either above or below the droplet to record a timed sequence of images of the process of drying thereof. Various chemical compounds coating the deposition slide can be used to enhance the test further. Image analysis includes data filtering, dividing the image into a plurality of overlapping windows, and analysis of formation and change in patterns over time. If used with biological fluids, the devices and methods of the invention can be used for rapid diagnosis of a variety of conditions and diseases.

Abstract: A handgrip for a colonoscope shaft capable of measuring and presenting to the operator of radial and longitudinal forces applied by the operator during the manipulation with the colonoscope. The handgrip includes an internal sleeve positioned over the shaft of the colonoscope so that it can be released and repositioned by depressing a release button. And external sleeve covers the internal sleeve and provides for a convenient grip by the operator. The only means of transmission of force applied by the operator from the external sleeve to the internal sleeve is the engaging means such as a flexible rectangular bar or a set of engaging plates imbedded between the external sleeve and internal sleeve. The engaging means are equipped with a set of sensors such as strain gages positioned on all sides of the bar to measure the forces between the sleeves, which correspond to the forces applied by the operator to the shaft of the colonoscope.

Abstract: A method and device for high resolution 3-D detection of changes in mechanical and structural properties of the breast tissue that are indicative of breast cancer development. A compact hand held device comprises a pressure sensor array, a self-contained motion tracking system integrated with the pressure sensor array, and an electronic unit with a display. Mechanical imaging of the breast is achieved by pressing the sensing pad onto the breast, oscillating it over breast tissue portions with sequential returning to a reference point. Analysis of pressure response data for oscillatory deformations comprises cumulative summation of a plurality of pressure patterns after spatially shifting every pattern by a pre-calculated value in an opposite direction of pressure sensor array motion. Determining mechanical and geometrical features of the breast inner structures includes formation of a 3-D mechanical image of the breast combining results of local scanning at all breast sites.

Abstract: A method of assessment of bone conditions comprises acquiring of unilateral sequential ultrasonic measurements along the trajectory over the surface of an examined bone. The method utilizes measurements of a set of ultrasonic parameters from a plurality of ultrasonic transfucers moved along the tested bone surface. Measured parameters are displayed as profile graphs characterizing bone conditions. The set of measured and displayed ultrasonic parameters can include: velocity of a longitudinal wave; velocity of a flexural wave; attenuation of the longitudinal wave; attenuation of the flexural wave; frequency slope of attenuation of the longitudinal wave; frequency slope of attenuation of the flexural wave; changes of spectral characteristics of propagating the longitudinal wave; and changes of spectral characteristics of propagating the flexural wave.

Abstract: A method and device in accordance with the present invention enable detecting changes in mechanical and structural properties of the breast tissue that are indicative of breast cancer development. In one embodiment of the invention, an array of force sensors based on PVDF piezopolymer film, data acquisition circuit, and a microprocessor are mounted in a hand held pad. Detection of nodules is achieved by pressing the sensing pad onto the breast, oscillating it over regions under investigation, and analyzing spectral and phase characteristics of the signal from the sensors in the array. The device is able to objectively detect presence of suspicious lesions in the breast and provide a warning signal.

Abstract: The present invention describes an electrooptical apparatus and method for monitoring cell growth in microbiological culture. The apparatus comprises an electrooptical cell filled up with a cell suspension and having electrodes and two orthogonal optical channels for passing through two light beams, an electrical generating means for supplying an alternating electrical current on said electrodes for inducing an alternating electrical field with predetermined frequency and strength in said electrooptical cell to give rise preferred orientation of the bacterial cells, an optical system for generating signals in response to the optical density changes in both optical channels by turning on and turning off said alternating electrical field, a temperature controlling means of the electrooptical cell, a cell suspension delivery means connected with the electrooptical cell, an electronic unit determining and displaying growth parameters of the bacterial cells.

Abstract: A pressure force sensing array is used to measure the surface stress pattern on soft tissues. The pattern of mechanical stress and the changes in the pattern as a function of the applied pressure, position of the array and time are processed to construct an image of the internal structure of the tissues. The detected parameters and processed image provide information useful in the detection and diagnosis of soft tissue pathologies such as breast and prostate tumors. The present invention relates to an apparatus particularly useful for mechanical imaging of the prostate which comprises a transrectal probe. The probe includes a probe shaft, a position sensor for determining the position of the tip and an array of force sensors for determining the pattern of pressure from tissue deformed by the tip.

Abstract: In one embodiment of the invention, a pressure sensor array, data acquisition circuit, and a microprocessor are mounted in a hand held pad. Detection of nodules is achieved by analyzing the dynamic and spatial features of the pressure pattern while the probe pressed to the breast is periodically moved transversely to the ribs. The ribs play a role as an amplifier of the measured effect. The device will be able to objectively detect the presence of lumps in a breast and provide a warning signal. Another embodiment of the invention is a clinical device for imaging the mechanical structure of the examined breast and diagnosing diseases accompanied by changes in the elasticity of breast tissue. This embodiment is made up of an electronically controlled mechanical scanning unit incorporated into a patient support bed. The mechanical scanning unit includes a compression mechanism and positioning system, a local pressure source located opposite a pressure sensor array, and electronic control and interface circuitry.

Abstract: A method and devices for Shear Wave Elasticity Imaging (SWEI). The method employs a focused acoustic pulse which remotely induces a shear wave in tissue. The values of the shear modulus and dynamic shear viscosity of tissue are evaluated from the values of propagation parameters of shear acoustic waves detected by various means including Doppler ultrasound and Magnetic Resonance Imaging. Several devices for carrying out the method are described. Devices based on the method can be used as a diagnostic tool in the detection of abnormalities in tissue, such as those caused by cancer or other lesions and characterizing processes in tissues accompanied by changes in their mechanical properties. The devices can also be used for assessment of brain tissue and evaluation of the biomechanical state of muscle.

Abstract: An apparatus and method for imaging a portion of the body tissue comprises support for a portion of the tissue, and a force applying member that tends to deform the tissue relative to a reference position, while at the same time a pressure pattern distribution is generated indicating areas of greater pressure which are a function of the amount of deformation and localized portions of the tissue being deformed.