Patents Assigned to Artificial Cell Technologies, Inc.
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Patent number: 10588954Abstract: Described herein are multilayer films that include modified polypeptide epitopes from Plasmodium falciparum, specifically a modified T* epitope. The multilayer films are capable of eliciting an immune response in a host upon administration to the host. The multilayer films can include at least one designed peptide that includes the modified T* polypeptide epitope from a Plasmodium protozoan.Type: GrantFiled: April 5, 2018Date of Patent: March 17, 2020Assignee: ARTIFICIAL CELL TECHNOLOGIES, INC.Inventors: James Gorham Boyd, Thomas J. Powell
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Patent number: 9975066Abstract: Layer by layer (“LBL”) construction of products by tangential flow filtration (TFF), or the like, is described, including computer controlled automation of such procedure for production of a multilayer coated core.Type: GrantFiled: May 22, 2015Date of Patent: May 22, 2018Assignee: ARTIFICIAL CELL TECHNOLOGIES, INC.Inventors: James Gorham Boyd, Naveen Palath, Edwin Jonathan Cardenas
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Patent number: 9968665Abstract: Described herein are multilayer films that include modified polypeptide epitopes from Plasmodium falciparum, specifically a modified T* epitope. The multilayer films are capable of eliciting an immune response in a host upon administration to the host. The multilayer films can include at least one designed peptide that includes the modified T* polypeptide epitope from a Plasmodium protozoan.Type: GrantFiled: September 13, 2016Date of Patent: May 15, 2018Assignee: ARTIFICIAL CELL TECHNOLOGIES, INC.Inventors: James Gorham Boyd, Thomas J. Powell
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Patent number: 9925252Abstract: Multilayer films are described that include polypeptide epitopes and a toll-like receptor ligand. The multilayer films are capable of eliciting an immune response in a host upon administration to the host. The multilayer films can include at least one designed peptide that includes one or more polypeptide epitopes from a virus, bacteria, fungus or parasite.Type: GrantFiled: February 24, 2016Date of Patent: March 27, 2018Assignee: ARTIFICIAL CELL TECHNOLOGIES, INC.Inventors: Thomas J. Powell, James Gorham Boyd
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Patent number: 9487593Abstract: Multilayer films comprise polypeptide epitopes from RSV. The multilayer films are capable of eliciting an immune response in a host upon administration to the host. The multilayer films include at least one designed peptide that includes one or more polypeptide epitopes from RSV. Specifically, the multilayer films include two polypeptide epitopes from RSV, such as an epitope that elicits a specific T-cell response such as a cytotoxic T-cell response, and an epitope that elicits a specific antibody response.Type: GrantFiled: July 7, 2011Date of Patent: November 8, 2016Assignee: ARTIFICIAL CELL TECHNOLOGIES, INCInventors: Thomas J. Powell, James Gorham Boyd
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Patent number: 9433671Abstract: Multilayer films comprise polypeptide epitopes from Plasmodium falciparum, specifically a circumsporozoite T1, B or T* epitope. The multilayer films are capable of eliciting an immune response in a host upon administration to the host. The multilayer films can include at least one designed peptide that includes one or more polypeptide epitopes from a Plasmodium protozoan.Type: GrantFiled: March 14, 2013Date of Patent: September 6, 2016Assignee: ARTIFICIAL CELL TECHNOLOGIES, INC.Inventor: Thomas J. Powell
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Patent number: 9302001Abstract: Multilayer films comprised of polypeptide epitopes and a toll-like receptor ligand. The multilayer films are capable of eliciting an immune response in a host upon administration to the host. The multilayer films can include at least one designed peptide that includes one or more polypeptide epitopes from a virus, bacteria, fungus or parasite.Type: GrantFiled: October 8, 2014Date of Patent: April 5, 2016Assignee: ARTIFICIAL CELL TECHNOLOGIES, INC.Inventors: Thomas J. Powell, James Gorham Boyd
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Patent number: 8883717Abstract: Multilayer films comprised of polypeptide epitopes and a toll-like receptor ligand are described. The multilayer films are capable of eliciting an immune response in a host upon administration to the host. The multilayer films can include at least one designed peptide that includes one or more polypeptide epitopes from a virus, bacteria, fungus or parasite.Type: GrantFiled: March 14, 2013Date of Patent: November 11, 2014Assignee: Artificial Cell Technologies, Inc.Inventors: Thomas J. Powell, James Gorham Boyd
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Publication number: 20130259946Abstract: Multilayer films comprised of polypeptide epitopes and a toll-like receptor ligand. The multilayer films are capable of eliciting an immune response in a host upon administration to the host. The multilayer films can include at least one designed peptide that includes one or more polypeptide epitopes from a virus, bacteria, fungus or parasite.Type: ApplicationFiled: March 14, 2013Publication date: October 3, 2013Applicant: ARTIFICIAL CELL TECHNOLOGIES, INC.Inventors: Thomas J. Powell, James Gorham Boyd
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Publication number: 20130259945Abstract: Multilayer films comprise polypeptide epitopes from Plasmodium falciparum, specifically a circumsporozoite T1, B or T* epitope. The multilayer films are capable of eliciting an immune response in a host upon administration to the host. The multilayer films can include at least one designed peptide that includes one or more polypeptide epitopes from a Plasmodium protozoan.Type: ApplicationFiled: March 14, 2013Publication date: October 3, 2013Applicant: ARTIFICIAL CELL TECHNOLOGIES, INC.Inventor: Thomas J. Powell
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Publication number: 20120009254Abstract: Multilayer films comprise polypeptide epitopes from RSV. The multilayer films are capable of eliciting an immune response in a host upon administration to the host. The multilayer films include at least one designed peptide that includes one or more polypeptide epitopes from RSV. Specifically, the multilayer films include two polypeptide epitopes from RSV, such as an epitope that elicits a specific T-cell response such as a cytotoxic T-cell response, and an epitope that elicits a specific antibody response.Type: ApplicationFiled: July 7, 2011Publication date: January 12, 2012Applicant: ARTIFICIAL CELL TECHNOLOGIES, INC.Inventors: Thomas J. Powell, James Gorham Boyd
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Patent number: 7973129Abstract: Disclosed herein are polypeptide multilayer films wherein a therapeutic agent is covalently linked to a first layer polypeptide. An advantage of such attachment is that the linked therapeutic agent can be controllably released from the multilayer film into the environment of the film upon the addition of a suitable stimulus. An advantage of the disclosed films and methods is enablement of environmentally-stimulated release under specific conditions.Type: GrantFiled: April 5, 2010Date of Patent: July 5, 2011Assignee: Artificial Cell Technologies, Inc.Inventor: Donald Templeton Haynie
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Patent number: 7888316Abstract: Disclosed herein are polypeptide multilayer films comprising a hybrid polypeptide comprising a first polypeptide segment and a second segment, the two segments being covalently joined by one or more non-peptidic linkages. The first segment comprises a polypeptide having a magnitude of net charge per residue of greater than or equal to 0.4, and a length of greater than or equal to about 12 amino acid residues. The second segment comprises a polypeptide or another polyelectrolyte.Type: GrantFiled: April 9, 2010Date of Patent: February 15, 2011Assignee: Artificial Cell Technologies, Inc.Inventor: Donald T. Haynie
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Patent number: 7807632Abstract: Disclosed herein are immunogenic compositions comprising a multilayer film comprising two or more layers of polyelectrolytes, wherein adjacent layers comprise oppositely charged polyelectrolytes. A first layer polyelectrolyte comprises an antigenic polypeptide comprising one or more surface adsorption regions covalently linked to one or more antigenic determinant regions, wherein the antigenic polypeptide and the one or more surface adsorption regions have the same polarity. The immunogenic compositions may be employed in methods of eliciting an immune response in a vertebrate organism.Type: GrantFiled: October 5, 2009Date of Patent: October 5, 2010Assignee: Artificial Cell Technologies, Inc.Inventor: Donald T. Haynie
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Patent number: 7807633Abstract: Disclosed herein are immunogenic compositions comprising a multilayer film comprising two or more layers of polyelectrolytes, wherein adjacent layers comprise oppositely charged polyelectrolytes. A first layer polyelectrolyte comprises an antigenic polypeptide comprising one or more surface adsorption regions covalently linked to one or more antigenic determinant regions, wherein the antigenic polypeptide and the one or more surface adsorption regions have the same polarity. The immunogenic compositions may be employed in methods of eliciting an immune response in a vertebrate organism.Type: GrantFiled: October 5, 2009Date of Patent: October 5, 2010Assignee: Artificial Cell Technologies, Inc.Inventor: Donald T. Haynie
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Patent number: 7807634Abstract: Disclosed herein are immunogenic compositions comprising a multilayer film comprising two or more layers of polyelectrolytes, wherein adjacent layers comprise oppositely charged polyelectrolytes. A first layer polyelectrolyte comprises an antigenic polypeptide comprising one or more surface adsorption regions covalently linked to one or more antigenic determinant regions, wherein the antigenic polypeptide and the one or more surface adsorption regions have the same polarity. The immunogenic compositions may be employed in methods of eliciting an immune response in a vertebrate organism.Type: GrantFiled: October 5, 2009Date of Patent: October 5, 2010Assignee: Artificial Cell Technologies, Inc.Inventor: Donald T. Haynie
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Publication number: 20100247633Abstract: Disclosed herein are polypeptide multilayer films comprising a hybrid polypeptide comprising a first polypeptide segment and a second segment, the two segments being covalently joined by one or more non-peptidic linkages. The first segment comprises a polypeptide having a magnitude of net charge per residue of greater than or equal to 0.4, and a length of greater than or equal to about 12 amino acid residues. The second segment comprises a polypeptide or another polyelectrolyte.Type: ApplicationFiled: April 9, 2010Publication date: September 30, 2010Applicant: ARTIFICIAL CELL TECHNOLOGIES, INC.Inventor: Donald Templeton Haynie
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Patent number: 7786076Abstract: Disclosed herein are immunogenic compositions comprising a multilayer film comprising two or more layers of polyelectrolytes, wherein adjacent layers comprise oppositely charged polyelectrolytes. A first layer polyelectrolyte comprises an antigenic polypeptide comprising one or more surface adsorption regions covalently linked to one or more antigenic determinant regions, wherein the antigenic polypeptide and the one or more surface adsorption regions have the same polarity. The immunogenic compositions may be employed in methods of eliciting an immune response in a vertebrate organism.Type: GrantFiled: October 5, 2009Date of Patent: August 31, 2010Assignee: Artificial Cell Technologies, Inc.Inventor: Donald T. Haynie
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Patent number: 7781399Abstract: Disclosed herein are immunogenic compositions comprising a multilayer film comprising two or more layers of polyelectrolytes, wherein adjacent layers comprise oppositely charged polyelectrolytes. A first layer polyelectrolyte comprises an antigenic polypeptide comprising one or more surface adsorption regions covalently linked to one or more antigenic determinant regions, wherein the antigenic polypeptide and the one or more surface adsorption regions have the same polarity. The immunogenic compositions may be employed in methods of eliciting an immune response in a vertebrate organism.Type: GrantFiled: October 5, 2009Date of Patent: August 24, 2010Assignee: Artificial Cell Technologies, Inc.Inventor: Donald T. Haynie
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Publication number: 20100189769Abstract: Disclosed herein are polypeptide multilayer films wherein a therapeutic agent is covalently linked to a first layer polypeptide. An advantage of such attachment is that the linked therapeutic agent can be controllably released from the multilayer film into the environment of the film upon the addition of a suitable stimulus. An advantage of the disclosed films and methods is enablement of environmentally-stimulated release under specific conditions.Type: ApplicationFiled: April 5, 2010Publication date: July 29, 2010Applicant: ARTIFICIAL CELL TECHNOLOGIES, INC.Inventor: Donald Templeton Haynie