Abstract: Disclosed are pyrazole compounds represented by formula (I), pharmaceutical compositions containing such compounds, a method for preparing such compounds, and use of the pyrazole compounds and the pharmaceutical compositions. Such compounds are useful for inhibiting IRAK family kinases, and also useful for treating diseases caused by IRAK family kinases, such as autoimmune diseases, inflammatory diseases and cancers.

Abstract: Provided in the present application are an amide compound, and an isomer, a pharmaceutically acceptable salt, and a pharmaceutical composition thereof, and the use thereof. The amide compound has a structure as represented by formula I. The amide compound of the present application has a significant JAK kinase inhibitory activity, especially a JAKI kinase inhibitory activity, has a higher inhibitory activity on JAK1 kinase than on JAK2 kinase, and can be used as a highly selective JAK1 kinase inhibitor. Therefore, the amide compound of the present application can be used for preparing drugs for treating JAK1 kinase-mediated diseases.