Abstract: A two-compartment syringe having a bypass through which the liquid can be forced into the medicament compartment by advance of the piston connected to the stem, has a brake retarding the displacement of this piston until it reaches the bypass to prevent undesired discharge of the injectable substance from the syringe. Once the latter piston has reached the bypass, the stem can be axially displaced independently of a braking action by the damping means for normal injection.